Mechanistic modeling of a continuous multi-segment multi-addition antisolvent crystallization of benzoic acid in a coiled flow inverter (CFI) crystallizer

Orehek, Jaka; Teslić, Dušan; Likozar, Blaž

doi:10.1016/j.seppur.2022.121571

Cited by 6 publications

(4 citation statements)

References 82 publications

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“…(c) The schematic and the photograph of the custom‐made multiantisolvent‐coiled flow inverter crystallizer. Reproduced with permission from reference [47]. (d) CFD results from a 218 L‐scale antisolvent crystallization process of aspirin and the effect of impeller speeds on the mixing behavior.…”

Section: Antisolvent Crystallization Of Pharmaceuticalsmentioning

confidence: 99%

“…In another study, Orehek et al. [47] developed a multi‐antisolvent coiled flow inverter crystallizer for continuous crystallization of benzoic acid in 20 and 40 µm with narrow particle size distribution. The schematic and the photograph of the custom‐made multi‐antisolvent coiled flow inverter crystallizer is shown in Fig.…”

Section: Antisolvent Crystallization Of Pharmaceuticalsmentioning

confidence: 99%

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Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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Continuous crystallization of pharmaceuticals has been in the center of attention during the past two decades, with a more focus on the large‐scale production of active pharmaceutical ingredients. The increasing demand for pharmaceuticals requires high‐throughput production of drug crystals with different solubilities, stabilities, shapes, habits, polymorphs, and size distributions. With numerous advantages including low cost, ease of scale‐up, and superior control over polymorph and size distribution of drug crystals, antisolvent crystallization is one of the most promising crystallization methods recently attempted. However, it fails to deliver the required characteristic where the crystal systems tend to grow and for the preparation of metastable polymorphs. This review focuses on the most recent efforts to tackle these drawbacks by coupling antisolvent crystallization with cooling, supercritical‐assisted, microfluidics‐assisted, and membrane‐assisted crystallization. This systematic review aims to provide a concise summary of each coupled antisolvent technique and their positive and negative aspects. This review can be used as a guideline for pharmacist, biologists, and chemists, who are interested in the crystal engineering of pharmaceuticals to pave the way for further developments in this field.

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Section: Antisolvent Crystallization Of Pharmaceuticalsmentioning

confidence: 99%

Section: Antisolvent Crystallization Of Pharmaceuticalsmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

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“…Benitez-Chapa et al used CFIs to carry out continuous antisolvent crystallization of flufenamic acid, and it was found that the crystal mean size of the final product decreased as the number of 90° flow inverters increased . Orehek et al (2022) utilized CFIs to implement multi-segment multi-addition continuous antisolvent crystallization of benzoic acid …”

Section: Introductionmentioning

confidence: 99%

“…16 Orehek et al (2022) utilized CFIs to implement multi-segment multi-addition continuous antisolvent crystallization of benzoic acid. 17 In this study, a loop setup combining the recycle loop, FO, HCs, and CFIs was designed as a continuous crystallizer for seeded antisolvent crystallization. Crystallization of paracetamol from the methanol−water solution was selected as a model system.…”

Section: Introductionmentioning

confidence: 99%

Continuous Antisolvent Crystallization Using Fluidic Devices: Fluidic Oscillator, Helical Coil, and Coiled Flow Inverter

Robertson

Ranade

2022

Ind. Eng. Chem. Res.

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Fluidic devices without moving parts are gaining more attention for continuous crystallization as they offer better mixing and number-up/scale-up possibilities. In this study, a loop setup with various combinations of devices, such as a fluidic oscillator, helical coils, and coiled flow inverters, was designed as a continuous crystallizer for seeded antisolvent crystallization of paracetamol in a methanol–water system. Care was taken to avoid particle settling and clogging while providing adequate residence time in the devices under consideration. The particle size distribution (PSD) of produced crystals was measured by offline imaging method using microscopy. The influence of fluidic device configurations, mode of operation, and residence time/batch time on the PSD of paracetamol crystals was investigated. A population balance model (PBM) was developed to interpret experimentally the observed PSD. The standard method of moments and lognormal distribution function with moment-based parameters (σ and μ) were used for simulating the evolution of PSD. Fitted kinetic parameters and developed PBM were able to simulate PSD over a wide operating range. The setup, approach, and model presented in this paper will be useful for understanding and designing continuous antisolvent crystallization using fluidic devices.

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Design of spherical agglomeration via salt-induced liquid–liquid phase separation

Cui,

Zhou,

Yin

2024

Chemical Engineering Science

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Mechanistic modeling of a continuous multi-segment multi-addition antisolvent crystallization of benzoic acid in a coiled flow inverter (CFI) crystallizer

Cited by 6 publications

References 82 publications

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Continuous Antisolvent Crystallization Using Fluidic Devices: Fluidic Oscillator, Helical Coil, and Coiled Flow Inverter

Design of spherical agglomeration via salt-induced liquid–liquid phase separation

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