Mechanistic study of reversible solid-state melt isomerization of 2-oxindoles to 2-quinolinones and its occurrence in a mass spectrometer

Martínez-Gudiño, Gelacio; Pérez-Rojas, Nadia A.; Trujillo-Serrato, Joel J.; Mora-Pérez, Yolanda; Suárez‐Castillo, Oscar R.; Morales‐Ríos, Martha S.

doi:10.1016/j.molstruc.2018.08.056

Cited by 3 publications

(1 citation statement)

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“…The NMR data of 5 were in accordance with those of a compound previously synthesized by Martínez-Gudiño. 14 However, it was characterized from a natural source for the first time. The absolute configuration of 5 was assigned as 8 S by comparing the experimental CD curve with the calculated one in Figure 5.…”

Section: Resultsmentioning

confidence: 99%

Small Molecule Constituents of Periplaneta americana and Their IL-6 Inhibitory Activities

Zhang

Yan

Wang

et al. 2021

Natural Product Communications

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Two new glycosides, periplanosides A (1) and B (2), 3 compounds reported from a natural source for the first time (3 − 5), and 6 known compounds 6 − 11 were isolated from the ethanol extract of Periplaneta americana (Linnaeus). Their structures, including absolute configurations, were unambiguously identified by comprehensive spectroscopic and chemical methods. Compound 3 is a racemate whose enantiomers were purified by chiral high-performance liquid chromatography . The biological evaluation results showed that compound 7 (0 − 20 μM) did not affect the viability of RAW264.7 cells and could effectively inhibit the production of interleukin-6 stimulated by lipopolysaccharide in a concentration-dependent manner, indicating the potential to develop novel agents against inflammation-related diseases.

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Section: Resultsmentioning

confidence: 99%