Mechano chemical synthesis of hydroxyapatite using dolomite

Amirthalingam, Nanthini; Thenmuhil, D.; Paramasivam, Manohar

doi:10.1016/j.matlet.2019.07.118

Cited by 12 publications

(2 citation statements)

References 12 publications

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“…The first significant mass loss of 4.8% was recorded at 160 • C, which is associated with the massive dehydration of the sample and the elimination of the bone structure and collagen components [44]. The tuna-bone-derived HAp exhibits multi-stage losses up to 800 • C, which can be attributed to the removal of CO 3 , H 2 O, and NH 3 content, suggesting the residual presence of matrix fiber organic compounds in the sample [45]. Figure 2c,d display the TG-DSC thermograms of pristine HAp and tuna-bone-derived HAp, respectively.…”

Section: Resultsmentioning

confidence: 99%

Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna-Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide

Kang

Park

et al. 2023

Cells

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In recent years, bone tissue engineering (BTE) has made significant progress in promoting the direct and functional connection between bone and graft, including osseointegration and osteoconduction, to facilitate the healing of damaged bone tissues. Herein, we introduce a new, environmentally friendly, and cost-effective method for synthesizing reduced graphene oxide (rGO) and hydroxyapatite (HAp). The method uses epigallocatechin-3-O-gallate (EGCG) as a reducing agent to synthesize rGO (E-rGO), and HAp powder is obtained from Atlantic bluefin tuna (Thunnus thynnus). The physicochemical analysis indicated that the E-rGO/HAp composites had exceptional properties for use as BTE scaffolds, as well as high purity. Moreover, we discovered that E-rGO/HAp composites facilitated not only the proliferation, but also early and late osteogenic differentiation of human mesenchymal stem cells (hMSCs). Our work suggests that E-rGO/HAp composites may play a significant role in promoting the spontaneous osteogenic differentiation of hMSCs, and we envision that E-rGO/HAp composites could serve as promising candidates for BTE scaffolds, stem-cell differentiation stimulators, and implantable device components because of their biocompatible and bioactive properties. Overall, we suggest a new approach for developing cost-effective and environmentally friendly E-rGO/HAp composite materials for BTE application.

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Section: Resultsmentioning

confidence: 99%

Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna-Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide

Kang

Park

et al. 2023

Cells

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“…Unlike the solid-state technique, which produces heterogenous powders with irregular geometry, the powders are fabricated with a definite shape due to the pressure agitation of surface-bonded species. Thus, this improves the thermodynamic & kinetic effects between the solids [30]. This technique possessed many merits; it is simple and reproductive of a solid-state approach in fabricating large quantity of HA.…”

Section: Synthesis Techniques Of Hamentioning

confidence: 99%

Synthesis Techniques of Bioceramic Hydroxyapatite for Biomedical Applications

Sadiq

Sudin

Idris

et al. 2023

JBBBE

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The need to develop surviving implants and bone substitutes with good biocompatibility, mechanical strength and bioactivity, without causing toxicity, immune rejection and cancer had attracted the attention of many researchers over the years. Hydroxyapatite (HA) is one of the excellent calcium phosphates and major mineral component of vertebrate bone and teeth, which considerably enhances the biocompatibility, mechanical strength and bioactivity of artificial biomaterials in the body system. In addition, it creates porous and rough coated surface that aids the cell attachment, proliferation and the growth of tissue on the bone implants. Due to its high demand in biomedical applications, scientists had developed several, simple and efficient techniques to produce HA. This review outlines several techniques of manufacturing HA and summarizes the merits and demerits of each technique. Keywords: Biomaterials, calcium phosphate, hydroxyapatite, preparation techniques and bone

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A Review on Synthesis, Characterisation, and Applications of Hydroxyapatite Nanoparticles

Najmi,

Singh

2024

Lecture Notes in Mechanical Engineering

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Mechano chemical synthesis of hydroxyapatite using dolomite

Cited by 12 publications

References 12 publications

Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna-Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide

Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna-Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide

Synthesis Techniques of Bioceramic Hydroxyapatite for Biomedical Applications

A Review on Synthesis, Characterisation, and Applications of Hydroxyapatite Nanoparticles

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