Mechanochemical solid acid/base reactions for obtaining biologically active preparations and extracting plant materials

Lomovsky, O. I.; Ломовский, О. И.; Orlov, Denis V.

doi:10.1080/17518253.2017.1339832

Cited by 32 publications

(18 citation statements)

References 57 publications

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“…Only in one study (Liang, Gu, & Ding, 1993), comparative studies were carried out, demonstrating that recrystallization of amorphized cellulose I into cellulose II proceeds much slower in lignin-containing materials than in other materials. (Lomovsky, Lomovskiy, & Orlov, 2017;Orlov, Bychkov, & Lomovsky, 2014).…”

Section: Principles Of the Mechanical And Mechanochemical Methods Amentioning

confidence: 99%

“…Adsorption on lignin causes quercetin destabilization to the highest extent. In the case of carbohydrate components, the ability to decrease the stability of sorbed quercetin during mechanical action decreases in the following sequence: crystalline cellulose > amorphous cellulose > hemicelluloses (Lomovsky, Lomovskiy, & Orlov, ; Orlov, Bychkov, & Lomovsky, ).…”

Section: Mechanical Pretreatment Of Plant Biomassmentioning

confidence: 99%

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Current achievements in the mechanically pretreated conversion of plant biomass

Bychkov

Podgorbunskikh

Bychkova

et al. 2019

Biotech & Bioengineering

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At present, “mechanochemistry” is synonymous with “grinding,” according to the views of a significant number of scientists and technologists. Often, one comes across the opinion that “the less the particle size, the better.” The cases of considering chemical reactions occurring during pretreatment, as well as considering changes in the ultrastructure of cell walls are extremely rare. Also, the wrong choice of the type of mechanical impact and the equipment used in most cases leads to excessive consumption of electrical energy and reduce economic efficiency. The review presents the currently available published data on mechanically activated processes for the pretreatment of plant materials and shows that when using mechanical treatment, it is necessary to look more closely at the phenomena occurring, rather than reducing everything to the production of fine and ultrafine powders. As a result of mechanical action, active surface radicals can form, hydrothermal chemical processes can occur, and mechanocomposites can form. The role of interphase processes, changes in surface chemistry, related dimensional effects, and the disordering of the crystal structure and amorphization should be taken into account. In addition, the physicochemical insights in mechanical pretreatment make it possible to more efficiently use the energy delivered to the material, and, consequently, increase the economic efficiency of the activation process.

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Section: Principles Of the Mechanical And Mechanochemical Methods Amentioning

confidence: 99%

Section: Mechanical Pretreatment Of Plant Biomassmentioning

confidence: 99%

Current achievements in the mechanically pretreated conversion of plant biomass

Bychkov

Podgorbunskikh

Bychkova

et al. 2019

Biotech & Bioengineering

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“…Критерием отбора было увеличение выхода водорастворимых веществ после механохимической обработки в воде не менее чем на 50 % по сравнению с необработанным сырьем. Применение карбоната натрия [5] -препарат (4) из травы рапса -Salmonella typhimurium, Shigella sonnei;…”

Section: материалы и методыunclassified

Mechanochemically Obtained Phytobiotics Suppress the Development of Pathogens

Lomovsky

Koptev²,

Leonova³

et al. 2021

Journal of Siberian Federal University. Chemistry

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A study of the bactericidal action of a number of phytopreparations obtained as a result of mechanochemical treatment of mixtures of plant raw materials with solid sodium carbonate in relation to 10 species of opportunistic bacteria was carried out. The investigated phytopreparations have a selective effect on 1-3 types of microorganisms. The effect of the additive action of phytopreparations in mixtures, which can be used for the prevention and treatment of diseases of animals and humans with an established bacterial etiology, has been discovered

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“…Using pretty similar liquid-liquid extraction, Takemoto et al purified 90 mg of IF from 80 g dried EtOAc extract of Chloranthus japonicus root besides using benzene: EtOAc for chromatography [39]. Regarding MCAE as a new extraction method in which the mechanical power such as milling is combined with the chemicals to increase the yield [84], it was also used by Liu et al to isolate IF from roots and rhizomes of Eleutherococcus senticosus. They showed that the MCAE method was more economical with a shorter extraction time.…”

Section: Isolation and Purificationmentioning

confidence: 99%

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

et al. 2020

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Isofraxidin (7-hydroxy-6, 8-dimethoxy coumarin) (IF) is a hydroxy coumarin with several biological and pharmacological activities. The plant kingdom is of the most prominent sources of IF, which, among them, Eleutherococcus and Fraxinus are the well-known genera in which IF could be isolated/extracted from their species. Considering the complex pathophysiological mechanisms behind some diseases (e.g., cancer, neurodegenerative diseases, and heart diseases), introducing IF as a potent multi-target agent, which possesses several herbal sources and the multiple methods for isolation/purification/synthesis, along with the unique pharmacokinetic profile and low levels of side effects, could be of great importance. Accordingly, a comprehensive review was done without time limitations until February 2020. IF extraction methods include microwave, mechanochemical, and ultrasound, along with other conventional methods in the presence of semi-polar solvents such as ethyl acetate (EtOAc). In addition to the isolation methods, related synthesis protocols of IF is also of great importance. From the synthesis point of view, benzaldehyde derivatives are widely used as precursors for IF synthesis. Along with the methods of isolation and biosynthesis, IF pharmacokinetic studies showed hopeful in vivo results of its rapid absorption after oral uses, leading to different pharmacological effects. In this regard, IF targets varieties of inflammatory mediators including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs). thereby indicating anticancer, cardioprotective, and neuroprotective effects. This is the first review on the synthesis, biosynthesis, isolation, and pharmacokinetic and pharmacological properties of IF in combating different diseases.

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Mechanochemical solid acid/base reactions for obtaining biologically active preparations and extracting plant materials

Cited by 32 publications

References 57 publications

Current achievements in the mechanically pretreated conversion of plant biomass

Current achievements in the mechanically pretreated conversion of plant biomass

Mechanochemically Obtained Phytobiotics Suppress the Development of Pathogens

Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties

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