Mechanochemistry: A Force of Synthesis

Do, Jean‐Louis; Friščić, Tomislav

doi:10.1021/acscentsci.6b00277

Cited by 1,058 publications

(652 citation statements)

References 116 publications

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“…Due to the collision of milling balls inside a planetary ball mill, mechanical energies can be utilized to easily break and build chemical bonds [27]. Moreover, mechanochemistry has been shown to enable unexpected reactions, like the dimerization of fullerenes [28].…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical Functionalization of Carbon Black at Room Temperature

Leistenschneider

Zürbes

Schneidermann

et al. 2018

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Carbon nanomaterials such as carbon blacks are intrinsically hydrophobic with limited wettability in aqueous media, thus restricting their potential applications. To improve their hydrophilicity, common methods tend to utilize harmful chemicals and conditions, such as a mixture of KMnO 4 and H 2 SO 4 or a complex and expensive synthesis setup. In our work, we report a simple method to improve the wettability of these materials by a mechanochemical treatment completed within 1 h at room-temperature utilizing a NH 3 solution. Besides increasing the specific surface area of the carbon black from 67 m 2 ·g −1 up to 307 m 2 ·g −1 , our process also incorporates nitrogen-and oxygen-containing functional groups into the carbon. This reduces the contact angle from 80 • to 30 • , confirming an enhanced wettability. Our work presents an easy, fast, and straightforward pathway towards the functionalization of carbon nanomaterials and can be of use in various applications where aqueous wettability is advantageous.

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Section: Introductionmentioning

confidence: 99%

Mechanochemical Functionalization of Carbon Black at Room Temperature

Leistenschneider

Zürbes

Schneidermann

et al. 2018

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“…The key advantages of grinding strategy over conventional approaches include its green [5], safe, simple, solvent-free conditions, as well as its facile work-up, high yield economy and environmental friendliness. Single crystal X-ray study identified the stereo-chemical structure of 2C, which can be also considered as a guide for the prepared derivatives.…”

Section: Conculsionmentioning

confidence: 99%

“…Recently, mechanochemistry offers a cleaner, more efficient alternative to a majority of conventional transformations [5], however, mechano heterocyclic chemistry (MHC) [5,6] draws the attention of heterocyclic chemists towards the uses of grindstone technique in green efficient synthesis of many heterocyclic systems [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of N-Containing Heterocycles via Mechanochemical Grinding and Conventional Techniques

Fahmy¹,

El‐Sayed²,

Hemdan³

et al. 2017

Asian J. Chem.

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Mechano heterocyclic chemistry is a recent quickly growing technique draws the attention of hetrocyclic chemists towards the use of grindstone technique in a solvent free green efficient clean synthesis of many heterocyclic systems. α,β-Epoxy ketones were used as a unique scaffold for synthesis of stable hydroxyazoles. The key advantage of grinding technique over the conventional thermal technique includes its simple, solvent free conditions, as well as facile work up with high yield economy. It is also successful in achieving three of the green chemistry objectives of a solvent free, high atom economy, save energy thus combining the features of both economic and environmental advantages.

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“…It is a low cost and green chemistry method employed in the pharmaceutical industry to obtain new solid phases of APIs such as cocrystals, salts, solvates and polymorphs. Solvent assisted grinding is a commonly used mechanochemical method to obtain solid new solid forms of APIs, and the advantages of this method are that it does not depend on the solubility of the compounds and the time reduction in the synthesis process [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical Synthesis and Crystal Structure of the Lidocaine-Phloroglucinol Hydrate 1:1:1 Complex

Magaña-Vergara

Cruz-Cruz²,

Peraza-Campos

et al. 2018

Crystals

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Molecular complexation is a strategy used to modify the physicochemical or biopharmaceutical properties of an active pharmaceutical ingredient. Solvent assisted grinding is a common method used to obtain solid complexes in the form of cocrystals. Lidocaine is a drug used as an anesthetic and for the treatment of chronic pain, which bears in its chemical structure an amide functional group able to form hydrogen bonds. Polyphenols are used as cocrystal coformers due to their ability to form O-H···X (X = O, N) hydrogen bond interactions. The objective of this study was to exploit the ability of phloroglucinol to form molecular complexes with lidocaine by liquid assisted grinding. The formation of the complex was confirmed by the shift of the O-H and C=O stretching bands in the IR spectra of the polycrystalline ground powders, suggesting the formation of O-H···O=C hydrogen bonds. Hydration of the complexes also was confirmed by IR spectroscopy and by powder X-ray diffraction. The molecular structure was determined by single crystal X-ray diffraction.

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Mechanochemistry: A Force of Synthesis

Cited by 1,058 publications

References 116 publications

Mechanochemical Functionalization of Carbon Black at Room Temperature

Mechanochemical Functionalization of Carbon Black at Room Temperature

Synthesis of N-Containing Heterocycles via Mechanochemical Grinding and Conventional Techniques

Mechanochemical Synthesis and Crystal Structure of the Lidocaine-Phloroglucinol Hydrate 1:1:1 Complex

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