Mechanoregulated trabecular bone adaptation: Progress report on in silico approaches

Smotrova, Ekaterina; Li, Si Min; Silberschmidt, Vadim V.

doi:10.1016/j.bbiosy.2022.100058

Cited by 2 publications

(1 citation statement)

References 88 publications

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“…Remodeling algorithms can be applied to cortical and trabecular bone. A recent review [ 81 ] detailed and compared computational models for trabecular bone remodeling.…”

Section: Why Do We Use Fe Models In Bone Adaptation Studies?mentioning

confidence: 99%

Using Finite Element Modeling in Bone Mechanoadaptation

Meslier

Shefelbine

2023

Curr Osteoporos Rep

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Purpose of the Review Bone adapts structure and material properties in response to its mechanical environment, a process called mechanoadpatation. For the past 50 years, finite element modeling has been used to investigate the relationships between bone geometry, material properties, and mechanical loading conditions. This review examines how we use finite element modeling in the context of bone mechanoadpatation. Recent Findings Finite element models estimate complex mechanical stimuli at the tissue and cellular levels, help explain experimental results, and inform the design of loading protocols and prosthetics. Summary FE modeling is a powerful tool to study bone adaptation as it complements experimental approaches. Before using FE models, researchers should determine whether simulation results will provide complementary information to experimental or clinical observations and should establish the level of complexity required. As imaging technics and computational capacity continue increasing, we expect FE models to help in designing treatments of bone pathologies that take advantage of mechanoadaptation of bone.

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“…Remodeling algorithms can be applied to cortical and trabecular bone. A recent review [ 81 ] detailed and compared computational models for trabecular bone remodeling.…”

Section: Why Do We Use Fe Models In Bone Adaptation Studies?mentioning

confidence: 99%

Using Finite Element Modeling in Bone Mechanoadaptation

Meslier

Shefelbine

2023

Curr Osteoporos Rep

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Experimental Evaluation of the Effect of Degradation on the Mechanical Behavior and Morphometric Characteristics of Functionally Graded Polymer Scaffolds

Elenskaya,

Vindokurov,

Sadyrin

et al. 2024

Polymers

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Bone transplantation ranks second worldwide among tissue prosthesis surgeries. Currently, one of the most promising approaches is regenerative medicine, which involves tissue engineering based on polymer scaffolds with biodegradable properties. Once implanted, scaffolds interact directly with the surrounding tissues and in a fairly aggressive environment, which causes biodegradation of the scaffold material. The aim of this work is to experimentally investigate the changes in the effective mechanical properties of polylactide scaffolds manufactured using additive technologies. The mechanism and the rate of the degradation process depend on the chosen material, contact area, microstructural features, and overall architecture of sample. To assess the influence of each of these factors, solid samples with different dimensions and layers orientation as well as prototypes of functionally graded scaffolds were studied. The research methodology includes the assessment of changes in the mechanical properties of the samples, as well as their structural characteristics. Changes in the mechanical properties were measured in compression tests. Microcomputed tomography (micro-CT) studies were conducted to evaluate changes in the microstructure of scaffold prototypes. Changes caused by surface erosion and their impact on degradation were assessed using morphometric analysis. Nonlinear changes in mechanical properties were observed for both solid samples and lattice graded scaffold prototypes depending on the duration of immersion in NaCl solution and exposure to different temperatures. At the temperature of 37 °C, the decrease in the elastic modulus of solid specimens was no more than 16%, while for the lattice scaffolds, it was only 4%. For expedited degradation during a higher temperature of 45 °C, these ratios were 47% and 16%, respectively. The decrease in compressive strength was no more than 32% for solid specimens and 17% for scaffolds. The results of this study may be useful for the development of optimal scaffolds considering the impact of the degradation process on their structural integrity.

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Mechanoregulated trabecular bone adaptation: Progress report on in silico approaches

Cited by 2 publications

References 88 publications

Using Finite Element Modeling in Bone Mechanoadaptation

Using Finite Element Modeling in Bone Mechanoadaptation

Experimental Evaluation of the Effect of Degradation on the Mechanical Behavior and Morphometric Characteristics of Functionally Graded Polymer Scaffolds

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