Medial Arterial Calcification

Lanzer, Peter; Hannan, Fadil; Lanzer, Jan D.; Janzen, Jan; Raggi, Paolo; Furniss, Dominic; Schuchardt, Mirjam; Thakker, Rajesh; Fok, Pak-Wing; Sáez-Rodríguez, Julio; Millán, Ángel; Sato, Yu; Ferraresi, Roberto; Virmani, Renu; Hilaire, Cynthia St.

doi:10.1016/j.jacc.2021.06.049

Cited by 166 publications

(115 citation statements)

References 142 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…In addition to these changes, a decrease in the levels of inhibitors against vascular calcification also causes the progression of vascular and valvular calcifications 25) . Phosphate is also known to be related to both vascular intimal and medial calcifications 26,27) . Mild-tomoderate coronary intimal calcification is associated with coronary events, such as acute myocardial infarction and unstable angina, and severe intimal and medial calcifications are related to impaired coronary microvascular circulation 28) .…”

Section: Discussionmentioning

confidence: 99%

Clinical Implication of Consistently Strict Phosphate Control for Coronary and Valvular Calcification in Incident Patients Undergoing Hemodialysis

Shimizu

Fujii

Kono

et al. 2023

JAT

View full text Add to dashboard Cite

Aims: Serum phosphate control is crucial for the progression of vascular and valvular calcifications. Strict phosphate control is recently suggested; however, there is a lack of convincing evidence. Therefore, we explored the effects of strict phosphate control on vascular and valvular calcifications in incident patients undergoing hemodialysis.Methods: A total of 64 patients undergoing hemodialysis from our previous randomized controlled trial were included in this study. Coronary artery calcification score (CACS) and cardiac valvular calcification score (CVCS) were evaluated using computed tomography and ultrasound cardiography at baseline and 18 months after the initiation of hemodialysis. The absolute changes in CACS (ΔCACS) and CVCS (ΔCVCS) and the percent change in CACS (%ΔCACS) and CVCS (%ΔCVCS) were calculated. Serum phosphate level was measured at 6, 12, and 18 months after the initiation of hemodialysis. Moreover, phosphate control status was evaluated using the area under the curve (AUC) by the amount of time spent with a serum phosphate level of ≥ 4.5 mg/dL and the extent to which this threshold exceeded over the observation period.Results: ΔCACS, %ΔCACS, ΔCVCS, and %ΔCVCS were significantly lower in the low AUC group than in the high AUC group. ΔCACS and %ΔCACS were also significantly lower. ΔCVCS and %ΔCVCS tended to be lower in patients whose serum phosphate level never exceeded 4.5 mg/dL than in those whose serum phosphate level continuously exceeded 4.5 mg/dL. AUC significantly correlated with ΔCACS and ΔCVCS. Conclusion:Consistently strict phosphate control may slow the progression of coronary and valvular calcifications in incident patients undergoing hemodialysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Implication of Consistently Strict Phosphate Control for Coronary and Valvular Calcification in Incident Patients Undergoing Hemodialysis

Shimizu

Fujii

Kono

et al. 2023

JAT

View full text Add to dashboard Cite

show abstract

“…Vascular calcification refers to the process of calcium deposition in the extracellular matrix of arterial walls. Vascular calcification involves deposition of mineral in the ECM, VSMCs apoptosis and osteogenic transformations, dysregulated expression of mineralization inhibitors, and microvesicle (MV) release et al [157][158][159] There is a mutually reinforcing relationship between vascular calcification and hypertension. Hypertension is a calcification-promoting stressor, 157 and vascular calcification can result in hypertension through arterial stiffness.…”

Section: Vascular Remodelingmentioning

confidence: 99%

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Yang

et al. 2023

Sig Transduct Target Ther

View full text Add to dashboard Cite

Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research, hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it. Hypertension is a condition that is named after its clinical features. Vascular function is a factor that affects blood pressure directly, and it is a main strategy for clinically controlling BP to regulate constriction/relaxation function of blood vessels. Vascular elasticity, caliber, and reactivity are all characteristic indicators reflecting vascular function. Blood vessels are composed of three distinct layers, out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function. The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development. In this manuscript, we will comprehensively review the signaling pathways involved in vascular function regulation and hypertension progression, including calcium pathway, NO-NOsGC-cGMP pathway, various vascular remodeling pathways and some important upstream pathways such as renin-angiotensin-aldosterone system, oxidative stress-related signaling pathway, immunity/inflammation pathway, etc. Meanwhile, we will also summarize the treatment methods of hypertension that targets vascular function regulation and discuss the possibility of these signaling pathways being applied to clinical work.

show abstract

“…Extra-coronary calcification, take thoracic and abdominal aortic calcification for example, is also implied as a strong predictor of future cardiovascular events [ 13 , 14 ]. Vascular calcification is a pathologic result of aberrant calcium and phosphate levels, which is marked with precipitation of calcium phosphate in arterial vessels [ 15 ]. Nevertheless, the most common stone components are calcium-based, with oxalate or phosphate, which represented over 75% of all stone phenotypes [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Vascular calcification on the risk of kidney stone: a meta-analysis

Huang

Xue

et al. 2023

Renal Failure

View full text Add to dashboard Cite

Background The association between vascular calcification (VC) and kidney stone is still inconclusive. Therefore, we conducted a meta-analysis to estimate the risk of kidney stone disease in subjects with VC. Methods To identify publications from related clinical studies, we performed a search on PubMed, Web of Science, Embase, and Cochrane Library databases from their inceptions until 1 September 2022. According to obvious heterogeneity, a random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Subgroup analysis was conducted trying to dissect the effects of VC in different segments and population regions in predicting kidney stone risk. Results Seven articles were included with a total number of 69,135 patients, of which 10,052 have vascular calcifications and 4728 have kidney stones. There was a significantly higher risk of kidney stone disease in participants with VC versus control (OR = 1.54, 95% CI: 1.13–2.10). Sensitivity analysis confirmed the stability of the results. VC can be separated into abdominal, coronary, carotid, and splenic aortic calcification while pooled analysis of abdominal aorta calcification did not indicate a significant higher kidney stone risk. An obvious higher risk of kidney stone was observed in Asian VC patients (OR = 1.68, 95% CI: 1.07–2.61). Conclusion Combined evidence of observational studies suggested patients with VC may be associated with an increased risk of kidney stone disease. Despite the predictive value was relatively low, it is still worth noting that patients with VC are under the threat of kidney stone disease.

show abstract

Medial Arterial Calcification

Cited by 166 publications

References 142 publications

Clinical Implication of Consistently Strict Phosphate Control for Coronary and Valvular Calcification in Incident Patients Undergoing Hemodialysis

Clinical Implication of Consistently Strict Phosphate Control for Coronary and Valvular Calcification in Incident Patients Undergoing Hemodialysis

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Vascular calcification on the risk of kidney stone: a meta-analysis

Contact Info

Product

Resources

About