Medial meniscus replacement by a tendon autograft. Experiments in sheep

Kohn, Dieter; Cj, Wirth; Reiss, G; Plitz, W.; Maschek, H.; Erhardt, W.; Wülker, Nikolaus

doi:10.1302/0301-620x.74b6.1447257

Cited by 109 publications

(74 citation statements)

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“…The possibility that tendon, when used as a ligament replacement, might change into a functionally adequate structure has been recognised [23,31,43], and tendon from the extensor apparatus of the knee will change to a meniscus-like structure when used as a meniscus substitute [25,26]. Removing tissue from this site has some morbidity [11], but this could be diminished by using another local tissue which is also capable of transformation under load and tension.…”

Section: Discussionmentioning

confidence: 99%

“…For light microscopy, the samples were embedded in Epon R or paraffin, then cut into 1 µm thick sections and stained with an alkalinised Toluidine Blue solution, Haematoxyleneosin or Van Giesson. The larger posterior part of the specimen was used for scanning electron microscopy [26].…”

Section: Methodsmentioning

confidence: 99%

“…The importance of the meniscus necessitates conservative resection [10,19], reconstruction [10,48,58] or replacement [18,20,26,51,54]. Three possibilities for replacement are (a) an allograft [18,20,54,58], (b) a meniscal prosthesis [47,49,51,53], and (c) an autograft [25,26].…”

Section: Introductionmentioning

confidence: 99%

“…Three possibilities for replacement are (a) an allograft [18,20,54,58], (b) a meniscal prosthesis [47,49,51,53], and (c) an autograft [25,26].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently the idea of autografts arose and tendons [25,26] and fatty tissue [15,30] have been used. Pediculated grafts of the infrapatellar fat pad changed to meniscus-like tissue when inserted between the joint surfaces [39].…”

Section: Introductionmentioning

confidence: 99%

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Medial meniscus replacement by a fat pad autograft

Kohn

Rudert

Wirth

et al. 1997

International Orthopaedics

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Three possibilities for replacement are (a) an allograft [18,20,54,58], (b) a meniscal prosthesis [47,49,51,53], and (c) an autograft [25,26].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Medial meniscus replacement by a fat pad autograft

Kohn

Rudert

Wirth

et al. 1997

International Orthopaedics

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Meniscal Replacements

Donahue

Maes

2006

Wiley Encyclopedia of Biomedical Engineering

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Menisci are fibrocartilagenous structures in the knee joint that act to distribute the load from the femur to the tibia. Menisci are frequently torn as a result of sporting activity or degenerative tears associated with aging. Approximately 12.5% of annual visits to orthopedic surgeons are related to knee injury, and of those visits, 43% are directly related to meniscal injuries (see review by McBride and Reid, 1988). Some tears do not heal because they either occur in the avascular region of the meniscus or are too complex for repair. Therefore, the common treatment for these types of tears is either complete or partial meniscectomy depending on the severity of the tear. However, meniscectomies have been shown to lead to degenerative arthritis in the knee. Therefore, in an effort to prevent premature arthritis caused by removal of the meniscus or a portion of the meniscus, meniscal replacement strategies are being investigated. This article will detail the basic structure and function of meniscal tissue and the attachments of the menisci to the surrounding structures. The strengths and weaknesses of various meniscal replacement strategies will be discussed, including autografts, meniscal allografts, synthetic prosthesis, and tissue‐engineered constructs. The success of meniscal replacements likely depends on their ability to restore normal meniscal function both biologically and biomechanically. Previous studies indicate that a number of biomechanical criteria are important for proper meniscal function, such as the material properties and geometry of the replacement tissue as well as the attachment of the replacement to the tibial plateau.

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Transplantation of Achilles Tendon Treated With Bone Morphogenetic Protein 7 Promotes Meniscus Regeneration in a Rat Model of Massive Meniscal Defect

Ozeki

Muneta

Koga

et al. 2013

Arthritis & Rheumatism

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ObjectiveThis study was undertaken to examine whether bone morphogenetic protein 7 (BMP-7) induces ectopic cartilage formation in the rat tendon, and whether transplantation of tendon treated with BMP-7 promotes meniscal regeneration. Additionally, we analyzed the relative contributions of host and donor cells on the healing process after tendon transplantation in a rat model.MethodsBMP-7 was injected in situ into the Achilles tendon of rats, and the histologic findings and gene profile were evaluated. Achilles tendon injected with 1 μg of BMP-7 was transplanted into a meniscal defect in rats. The regenerated meniscus and articular cartilage were evaluated at 4, 8, and 12 weeks. Achilles tendon from LacZ-transgenic rats was transplanted into the meniscal defect in wild-type rats, and vice versa.ResultsInjection of BMP-7 into the rat Achilles tendon induced the fibrochondrocyte differentiation of tendon cells and changed the collagen gene profile of tendon tissue to more closely approximate meniscal tissue. Transplantation of the rat Achilles tendon into a meniscal defect increased meniscal size. The rats that received the tendon treated with BMP-7 had a meniscus matrix that exhibited increased Safranin O and type II collagen staining, and showed a delay in articular cartilage degradation. Using LacZ-transgenic rats, we determined that the regeneration of the meniscus resulted from contribution from both donor and host cells.ConclusionOur findings indicate that BMP-7 induces ectopic cartilage formation in rat tendons. Transplantation of Achilles tendon treated with BMP-7 promotes meniscus regeneration and prevents cartilage degeneration in a rat model of massive meniscal defect. Native cells in the rat Achilles tendon contribute to meniscal regeneration.

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Medial meniscus replacement by a tendon autograft. Experiments in sheep

Cited by 109 publications

References 0 publications

Medial meniscus replacement by a fat pad autograft

Medial meniscus replacement by a fat pad autograft

Meniscal Replacements

Transplantation of Achilles Tendon Treated With Bone Morphogenetic Protein 7 Promotes Meniscus Regeneration in a Rat Model of Massive Meniscal Defect

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