Mediastinal Liposarcoma: Case Report and Literature Review

Llano, Jeronimo Garcialopez De; Mijares, Maria Fernanda; Vasudevan, Vanitha; Arrangoiz, Rodrigo; Sastry, Amit; Cruz, F.; Garcia, Jennifer Fernandez; Legaspi, Adrian

doi:10.4236/jct.2021.124020

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…4 Histologic examination revealed 35 cases of well-differentiated liposarcoma (WDL), 21 cases of DDL, 21 cases of myxoid liposarcoma, 6 cases of pleomorphic liposarcoma (PL), 1 case of myxoid pleomorphic liposarcoma, and 11 cases of unstated type, as detailed in the Supplemental Table . PMLs develop most commonly in the posterior mediastinum in approximately 48% of cases, followed by 28% in the anterior mediastinum and 11% in the middle mediastinum. 6 The DDL we report in this study occurred in the posterior mediastinum. The radiologic features of mediastinal liposarcomas are nonspecific but are suggestive of the diagnosis.…”

Section: Discussionmentioning

confidence: 61%

“…PMLs develop most commonly in the posterior mediastinum in approximately 48% of cases, followed by 28% in the anterior mediastinum and 11% in the middle mediastinum. 6 The DDL we report in this study occurred in the posterior mediastinum. The radiologic features of mediastinal liposarcomas are nonspecific but are suggestive of the diagnosis.…”

Section: Discussionmentioning

confidence: 61%

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Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Rao,

Zhu,

Yang

2023

SAGE Open Medical Case Reports

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Liposarcoma is a carcinomatous mesenchymal tumor with various histologic features and is the most common soft tissue sarcoma originating in adipose tissue. Liposarcoma commonly occurs in the lower extremities and retroperitoneum but rarely in the mediastinum, specially extending into the thoracic cavity. We report a giant primary liposarcoma of the posterior mediastinum in a 63-year-old female who complained of cough, sputum, and pain in the right chest wall. A computed tomography scan of the chest showed a giant mass of 24 × 15 × 24 cm in the posterior mediastinum of the right thoracic cavity. After a thorough examination, no suspected lipomatous lesions were found elsewhere in the patient’s body. The patient underwent a thoracotomy to remove the mediastinal mass through a right thoracic approach. Subsequently, hematoxylin–eosin staining revealed dedifferentiated liposarcoma (DDL), immunohistochemistry showed positive expression of cyclin-dependent kinase 4, and murine double minute 2 (MDM2), in addition, fluorescence in situ hybridization for the MDM2 gene was also positive, which suggested DDL. The patient was discharged without any complications, and no metastasis or recurrence was observed after 19 months of follow-up. To provide a reference for clinical diagnosis and treatment, we reviewed and discussed the literature on primary liposarcoma of the mediastinum.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 61%

Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Rao,

Zhu,

Yang

2023

SAGE Open Medical Case Reports

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“…Wide resection of the chest wall however risks thoracic cavity failure and subsequent pulmonary failure 10 . The approach to access mediastinal tumor is Clamshell incision, median sternotomy, anterolateral and posterolateral sternotomy, and the median sternotomy is a common approach used because it provides better exposure to superior and anterior mediastinal lesion 15 . In this case we performed a sternotomy surgery to evacuate metastasis mass in this patient.…”

Section: Discussionmentioning

confidence: 99%

Massive Primary Leiomyosarcoma on Cavum Thorax : A Very Rare Case

Atin,

Prasetyanto,

Valerie Gunawan

et al. 2023

JARMHS

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The cavum thorax primary leiomyosarcoma is extremely rare and unusual case. leiomyosarcoma as smooth muscle carcinoma could be comes from various part of body as primary site, but in the case of cavum thorax leiomyosarcoma its estimated only 1-4 of all soft tissue sarcoma. In this report we present a 69 years old woman came to the outpatient clinic with a big lump in the chest. This lump has been felt for 1 year and was a big and bizarre looking tumor, pain was felt in the right chest with intensity of 4-5 visual analog scale. Difficulty to breath and shortness of breath was not complained by the patient, nausea and vomiting was not complained. The patient has a history of uterine tumor that has been done by surgery. Diagnostic test of Multidetector Computed Tomography (MDCT) scan and ultrasonography has been done in this patient, and show a suggestive malignant soft tissue tumor. The surgery has been done with preoperative internal mammary artery embolization to prevent massive bleeding. A 15 cm length, 9 cm wide and 500 grams of weight tumor was evacuated. The immunohistochemistry examination was performed to the tumor specimen, and the result was a leiomyosarcoma tissue. A good examination, early detection with adequate diagnostic tools and adequate surgery as the only option of treatment is a predicting factor of successful treatment, due to lack of treatment option and ineffectiveness use of adjuvant therapy.

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“…Liposarcomas mainly arise from the soft tissues of the extremities and the retroperitoneal region [ 1 ]. On the other hand, mediastinal liposarcoma constitutes a rare entity, accounting for fewer than 1% of mediastinal tumors, and approximately 2% of liposarcomas [ 2 ]. The literature contains reports of mediastinal liposarcomas originating from all mediastinal compartments.…”

Section: Introductionmentioning

confidence: 99%

Dedifferentiated Mediastinal Liposarcoma: A Case Report

Anestiadou,

Tsakona,

Tsagkaropoulos

et al. 2024

Cureus

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Liposarcoma is the most common soft tissue sarcoma type in adults, originating mainly from the retroperitoneum and lower extremities. Mediastinal liposarcomas constitute an extremely rare clinical entity of mesenchymal origin. Among subtypes, dedifferentiated liposarcoma is characterized by poor survival, but little is known about its biological behavior. We present the case of a 78-year-old male patient who presented with vague symptoms, predominantly dyspnea and chest pain. Imaging revealed a large mediastinal mass and surgical resection was performed in a piecemeal manner due to the inability to achieve a microscopically negative surgical margin (R0 resection) for the residual tumor. Histological examination confirmed the diagnosis of dedifferentiated liposarcoma. The patient’s postoperative course was uneventful, with discharge from the hospital on the 10th postoperative day. However, local recurrence was detected after two months and the patient died four months after the operation. The present case report highlights the importance of radical excision for the prevention of local recurrence and the presentation of histological characteristics of this tumor. Radical surgical resection remains the fundamental treatment, while chemo and radiotherapy may have an adjuvant role. In cases of inability to obtain negative margins, surgical debulking can offer symptomatic relief.

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Mediastinal Liposarcoma: Case Report and Literature Review

Cited by 4 publications

References 8 publications

Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Giant primary liposarcoma of the mediastinum: A case report and review of the literature

Massive Primary Leiomyosarcoma on Cavum Thorax : A Very Rare Case

Dedifferentiated Mediastinal Liposarcoma: A Case Report

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