Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products

Qiu, Guixing; Ding, Wenjiang; Tian, Wei; Qin, Ling; Zhao, Yu; Zhang, Lianmeng; Lü, Jian; Chen, Daijie; Yuan, Guangyin; Wu, Chengtie; Lu, Bingheng; Du, Ruxu; Chen, Jimin; Elbestawi, M.A.; Gu, Zhongwei; Li, Dichen; Sun, Wei; Zhao, Yuanjin; He, Jie; Jin, Dadi; Liu, Bin; Zhang, Kai; Li, Jianmo; Leong, Kam W.; Zhao, Dewei; Hao, Dingjun; Ao, Yingfang; Deng, Xuliang; Yang, Huilin; Hsu, Shao-Keh; Chen, Yingqi; Li, Long; Fan, Jianping; Nie, Guohui; Chen, Yun; Zeng, Hui; Chen, Wei

doi:10.1016/j.eng.2020.10.002

Cited by 14 publications

(12 citation statements)

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“…Powder metallurgy, 3D printing, and additive manufacturing are just some of the potential manufacturing techniques. Porous implants and implant-scaffolds, both metal, and ceramic, can be designed and manufactured using additive methods, the so-called 3D printing [139,[282][283][284][285][286][287][288][289][290][291]. However, powder engineering is still offered wide possibilities, traditionally called powder metallurgy [137,138,152,292,293].…”

Section: Examples Of Application Of Various Biomaterials In Medicine and Dentistrymentioning

confidence: 99%

“…Figure 29 shows an example of manufacturing a full-arch prosthetic bridge based on tooth abutments through milling in a CNC center from conventionally cast discs. Porous materials made from powders by additive methods are very useful in some applications [137,138,[282][283][284][285][286][287][288]292,293]. Figure 30 shows the results of studies on selectively laser sintered porous titanium [144], including the structure observed in the highresolution transmission electron microscope HRTEM.…”

Section: Examples Of Application Of Various Biomaterials In Medicine and Dentistrymentioning

confidence: 99%

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Effect of Biomedical Materials in the Implementation of a Long and Healthy Life Policy

Dobrzański¹,

Dobrzańska-Danikiewicz

Dobrzański³

2021

Processes

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This paper is divided into seven main parts. Its purpose is to review the literature to demonstrate the importance of developing bioengineering and global production of biomaterials to care for the level of healthcare in the world. First, the general description of health as a universal human value and assumptions of a long and healthy life policy is presented. The ethical aspects of the mission of medical doctors and dentists were emphasized. The coronavirus, COVID-19, pandemic has had a significant impact on health issues, determining the world’s health situation. The scope of the diseases is given, and specific methods of their prevention are discussed. The next part focuses on bioengineering issues, mainly medical engineering and dental engineering, and the need for doctors to use technical solutions supporting medicine and dentistry, taking into account the current stage Industry 4.0 of the industrial revolution. The concept of Dentistry 4.0 was generally presented, and a general Bioengineering 4.0 approach was suggested. The basics of production management and the quality loop of the product life cycle were analyzed. The general classification of medical devices and biomedical materials necessary for their production was presented. The paper contains an analysis of the synthesis and characterization of biomedical materials supporting medicine and dentistry, emphasizing additive manufacturing methods. Numerous examples of clinical applications supported considerations regarding biomedical materials. The economic conditions for implementing various biomedical materials groups were supported by forecasts for developing global markets for biomaterials, regenerative medicine, and tissue engineering. In the seventh part, recapitulation and final remarks against the background of historical retrospection, it was emphasized that the technological processes of production and processing of biomedical materials and the systematic increase in their global production are a determinant of the implementation of a long and healthy policy.

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Section: Examples Of Application Of Various Biomaterials In Medicine and Dentistrymentioning

confidence: 99%

Section: Examples Of Application Of Various Biomaterials In Medicine and Dentistrymentioning

confidence: 99%

Effect of Biomedical Materials in the Implementation of a Long and Healthy Life Policy

Dobrzański¹,

Dobrzańska-Danikiewicz

Dobrzański³

2021

Processes

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“…Bio printing is a type of additive manufacturing in which organic materials are used to produce organic tissues in high demand in the medical sector [21][22][23]. The most active methods of the bio printing technologies incorporate laser-assisted printing, extrusion-based and droplet-based.…”

Section: Bio Printing In Tissue Engineeringmentioning

confidence: 99%

The amber nano fibers development prospects to expand the capabilites of textile 3D printing in the general process of fabrication methods

Viļuma-Gudmona

Ļašenko

Sanchaniya

et al. 2021

Engineering for Rural Development

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The amber nano fibres are bio-active composites which could be applied in three-dimensional printing. The idea of using the amber for creating a new 3D printing material, including technological composition of the innovative amber nano and micro fibres is based on the hypothesis that organic compounds of succinite have an effective impact on living cells, including reparative, stimulating, for sedative effects as well protective properties from electro-magnetic field. To produce amber nano fibres, bioactive components were used that were isolated from the succinite and tested (in vitro) in the scientific laboratories. Three-dimensional printing is an emerging technology, which has been initially used to design and generate three-dimensional structures mainly for transplantation therapies. This process, which can be used for a variety of polymers, is becoming an increasingly essential component of biotechnological advancements. This article discusses the foundations of this technology, namely the processes used in conventional three-dimensional printing; it also discusses tissue engineering, a discipline of which new implementations of this technology are used as bio printing. The shortcomings of tissue engineering are addressed, including the failure of existing technology to manufacture nanofiber-based constructs used in blood vessels, cartilage, artery valves, tendon, cardiac muscle valves, muscle, and cornea. From this need for nanofiber processing, electrospinning is proposed as a possible roadmap for imminent tissue engineering threedimensional printing technologies, and finally, the latest integration of this technology with three-dimensional printing is addressed, highlighting the existing shortcomings in maintaining mandatory nano resolutions.

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“…Targeted therapeutic nanoparticles have attracted increasing attention in the fields of precision medicine and clinical translations [9–15] . The nanoformulated carriers selectively functionalized for delivering payloads to tumors offer a robust and unique approach to enhance solubility and bioavailability of the assembled drugs [16] .…”

Section: Figurementioning

confidence: 99%

“…Targeted therapeutic nanoparticles have attracted increasing attention in the fields of precision medicine and clinical translations. [9][10][11][12][13][14][15] The nanoformulated carriers selectively functionalized for delivering payloads to tumors offer a robust and unique approach to enhance solubility and bioavailability of the assembled drugs. [16] There are several nanomaterials developed to actively engage with cancers employing building blocks such as inorganic particles, synthetic polymers or liposomes.…”

mentioning

confidence: 99%

Improving Bioavailability of Hydrophobic Prodrugs through Supramolecular Nanocarriers Based on Recombinant Proteins for Osteosarcoma Treatment

Wang

Zhang

et al. 2021

Angewandte Chemie

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Supramolecular nanodrug assembly driven by supramolecular chemistry is becoming a powerful strategy for medication. The potential of engineered proteins as building blocks for nanoformulations is rarely investigated. Here, we developed a new generation of recombinant proteinbased nanodrug carriers, which is very efficient for loading and delivering the hydrophobic prodrug aldoxorubicin. Significantly enhanced anti-tumor effects in osteosarcoma (OS) models were observed. The half-life of the nanodrug reached almost two days and the corresponding bioavailability increased by 17-fold. This is significantly superior to other drug counterparts, empowering long-acting OS treatment scenarios. Importantly, off-target side effects of the prodrug, including cardiotoxicity and lung-metastasis, were greatly mitigated with our medication. Thus, our assembly strategy enables the customized design of advanced nanodelivery systems employing broader biomaterial building blocks for cancer therapy.

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Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products

Cited by 14 publications

References 0 publications

Effect of Biomedical Materials in the Implementation of a Long and Healthy Life Policy

Effect of Biomedical Materials in the Implementation of a Long and Healthy Life Policy

The amber nano fibers development prospects to expand the capabilites of textile 3D printing in the general process of fabrication methods

Improving Bioavailability of Hydrophobic Prodrugs through Supramolecular Nanocarriers Based on Recombinant Proteins for Osteosarcoma Treatment

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