Medical algorithm: Diagnosis and management of histaminergic angioedema

Ferrer, Marta; Rodríguez‐Garijo, Nuria; Sabaté‐Brescó, Marina

doi:10.1111/all.15618

Cited by 3 publications

(2 citation statements)

References 13 publications

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“… 1 In this way, CHA is apparently easily distinguishable from AE-BK. 13 However, differentiating CHA from other forms of AE-MC may prove more complex.…”

Section: Discussionmentioning

confidence: 99%

Predictive model to differentiate chronic histaminergic angioedema and chronic spontaneous urticaria with angioedema

Láinez-Nuez,

Salas-Parra,

Juárez-Guerrero

et al. 2024

Journal of Allergy and Clinical Immunology: Global

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“… 1 In this way, CHA is apparently easily distinguishable from AE-BK. 13 However, differentiating CHA from other forms of AE-MC may prove more complex.…”

Section: Discussionmentioning

confidence: 99%

Predictive model to differentiate chronic histaminergic angioedema and chronic spontaneous urticaria with angioedema

Láinez-Nuez,

Salas-Parra,

Juárez-Guerrero

et al. 2024

Journal of Allergy and Clinical Immunology: Global

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“…About 50 % of patients are often accompanied by urticaria, and anti-allergic drugs or glucocorticoids are usually effective. [10,11] After reviewing previous literature and consulting clinical experts, we determined the symptom as angioedema caused by an allergic reaction to a drug. Few cases of vascular edema induced by Sintilimab have reported.…”

Section: How To Define the Symptom Of Swelling Along The Vascular Dir...mentioning

confidence: 99%

A rare presentation of Sintilimab-induced swelling along the vessels: Case report

Liu

Xia

et al. 2023

Medicine

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Rationale: Immune-related adverse events are occasionally reported in Sintilimab treatment. This study reports a forward and reverse swelling case along the vein after infusion of Sintilimab. At present, swelling along the vascular direction during peripheral infusion are limitedly reported at home and abroad, especially when choosing a vein with thick, elastic, and good blood return.Patient concerns: A 56-year-old male who suffered from esophageal cancer and liver cancer and received albumin-bound paclitaxel and nedaplatin chemotherapy in combination with Sintilimab immunotherapy appeared swelling along the vessel after infusion of Sintilimab. The patient was punctured 3 times.Diagnoses: Sintilimab-induced vascular edema may be a side effect resulted from a combination of variables such as relatively poor vascular function of the patient, chemical extravasation, allergic skin reactions, venous valves, vascular intima, and diameter stenosis. Sintilimab rarely causes vascular edema only when drug allergic reaction is the underlying factor. As only a few cases of vascular edema caused by Sintilimab have been reported, causes to such a drug-induced vascular edema remained unclear.Interventions: The swelling was controlled by an intravenous specialist nurse according to delayed extravasation treatment and the doctor anti-allergy treatment, but the uncertainty of repeated puncture and symptom diagnosis caused pain and anxiety to the patient and his family.Outcomes: The symptom of swelling was gradually relieved after the anti-allergic treatment. The patient completed the following drug infusion without discomfort after the third puncture. When the patient was discharged the next day, swelling in his both hands disappeared, and the patient had no anxiety or discomfort.Lessons: The side effects of immunotherapy may accumulate over time. Early identification and appropriate nursing management are the keys to minimizing patients' pain and anxiety. To effectively treat symptoms, nurses could benefit from quickly identifying the source of swelling.

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Bradykinin Metabolism and Drug-Induced Angioedema

Smolińska

Antolín‐Amérigo

Popescu

2023

IJMS

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Bradykinin (BK) metabolism and its receptors play a central role in drug-induced angioedema (AE) without urticaria through increased vascular permeability. Many cardiovascular and diabetic drugs may cause BK-mediated AE. Angiotensin-converting enzyme inhibitors (ACEIs) and neprilysin inhibitors impair BK catabolism. Dipeptidyl peptidase-IV (DPP-IV) inhibitors reduce the breakdown of BK and substance P (SP). Moreover, angiotensin receptor blockers, thrombolytic agents, and statins may also induce BK-mediated AE. Understanding pathophysiological mechanisms is crucial for preventing and treating drug-induced AE.

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Medical algorithm: Diagnosis and management of histaminergic angioedema

Cited by 3 publications

References 13 publications

Predictive model to differentiate chronic histaminergic angioedema and chronic spontaneous urticaria with angioedema

Predictive model to differentiate chronic histaminergic angioedema and chronic spontaneous urticaria with angioedema

A rare presentation of Sintilimab-induced swelling along the vessels: Case report

Bradykinin Metabolism and Drug-Induced Angioedema

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