The subject of the study is the norms of current legislation regulating the creation and application of artificial intelligence technology in healthcare, including acts of technical regulation, as well as available scientific research by domestic and foreign scientists in the field presented. In recent years, foreign experts have conducted a significant amount of research on the development of ethical principles for the use of artificial intelligence in healthcare. However, these works tend to be abstract and do not explain what justifies and justifies their recommendations and how these recommendations should be used in practice. In turn, in the Russian Federation at the moment there is a small number of domestic studies devoted to a comprehensive study of ethical principles that should guide subjects engaged in the creation and use of medical devices based on artificial intelligence technologies, which confirms the relevance and significance of our research.Objective: to develop a system of ethical principles for the creation and application of artificial intelligence technologies in the field of healthcare, which will serve as the basis for the legal regulation of public relations in the presented area.Methods: the methodological basis of the system of ethical principles for the creation and application of artificial intelligence technologies was made up of general scientific and private scientific methods of scientific cognition, including analysis, synthesis, deduction, induction, classification, analogy and comparison.Results: to the attention of lawyers, scientists and practitioners, medical professionals, members of clinical ethics committees, medical ethics specialists, representatives of law– making bodies, government departments, the business community and public organizations, patients, as well as a wide range of readers interested in the digital transformation of the healthcare system, ethical principles for the creation and application of artificial health technologies are proposed intelligence in healthcare, which can serve as the basis for the formation of an appropriate system of legal regulation. The stated goal has been achieved, which is confirmed by the development of a system of ethical principles that serve as the basis for the development of a system of legal regulation of artificial intelligence technologies in healthcare. The developed ethical principles can be used to further improve domestic legislation, and also lay the foundation for further research.