Medical interventions for high-grade vulval intraepithelial neoplasia

Vulvar intraepithelial neoplasia

“…A meta-analysis of randomized control studies, assessing 104 participants, confirmed these findings [46].…”

“…To date, no treatment achieves these goals, and high morbidity and recurrences associated with surgical interventions make it necessary to evaluate the formal evidence available on less invasive but effective interventions for VIN [46].…”

Spanish consensus on vulvar disorders in postmenopausal women

“…We advocate conservative treatment while maintaining the objectives of preventing vulvar cancer, alleviating symptoms and preserving the patient's anatomy and vulval function whenever possible [30,31]. Among surgical modalities, wide local excision with free borders, laser ablation, ultrasound or topical therapy with imiquimod associated with resection are included [32,33]. VIN relapses in a third of women, 3% will already have a hidden carcinoma and up to 10% will develop squamous carcinoma [33].…”

Traitement des néoplasies vulvaires intra-épithéliales par imiquimod

“…En 2011, Pepas et al [13] ont mené une revue publié e dans la Cochrane Database sur le traitement mé dical des VIN. Cette revue incluait 3 essais comparant l'efficacité de l'imiquimod versus placebo et un essai portant sur l'indole-3-carbinol.…”