Medication Adherence in Outpatients with Arterial Hypertension

Lalić, Jelena; Radovanović, Radmila Veličković; Mitić, Branka; Nikolic, V.T.; Spasić, Ana; Koraćević, Goran

doi:10.2478/afmnai-2013-0013

Cited by 15 publications

(19 citation statements)

References 16 publications

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“…On the other hand, a significantly lower level of adherence was identified in a study with elderly patients in Serbia. In this study patients less than 65 years were found to be more likely to adhere to their prescribed treatment, compared to older patients (AOR = 6.0; 95% CI: 2.76 -13.04) [28].…”

Section: Demographic Factorsmentioning

confidence: 86%

“…Hypertensive patients who experienced side effects of their medications were less adherent to their medication than those who did not experience side effects in Palestine (AOR = 4.58; 95% CI: 1.87 -11.25) and Serbia (OR = 7.95; 95% CI: 1.48 -42.6) [28] [38]. Qualitative studies in Malaysia [51] and Nigeria [40] also found perceived side effects were inhibitors of antihypertensive medication adherence.…”

Section: Mmas 4 Ethiopia; N = 384 Open Journal Of Epidemiologymentioning

confidence: 90%

“…Lower levels of adherence in elderly patients with longer duration of antihypertensive therapy were also found in Serbia [28]. On the other hand, patients with shorter duration of hypertension were less likely to be adherent to treatment in Pakistan (<5 years) (AOR = 0.11, 95% CI: 0.013 -0.955) [44] and China (<3 years) (AOR = 3.31; 95% CI: 1.91 -5.72; P < 0.001) [56].…”

Section: Mmas 4 Ethiopia; N = 384 Open Journal Of Epidemiologymentioning

confidence: 99%

“…In Nepal, those with no family history of hypertension were less adherent to their medications compared to those with a family history of high BP (OR = [28]. Similarly, the average systolic and diastolic blood pressure for non-adherents was significantly higher (P = 0.05) than that in adherents in Malaysia [54].…”

Section: Treatment And/or Disease Related Factorsmentioning

confidence: 99%

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A Systematic Review of Factors Influencing Medication Adherence to Hypertension Treatment in Developing Countries

Dhar¹,

Dantas²,

Ali³

2017

OJEpi

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Background: Coronary heart disease (CHD), a complication of hypertension, is one of the most important and common causes of morbidity, hospitalisation, and mortality among hypertensive population. In recent decades, increased urbanisation and changes to lifestyle, diet and physical activity in developing countries have led to a major increase in the population incidence of chronic diseases including CHD. Poor medication adherence is one of the leading causes of failure to achieve hypertension control. The objective of this systematic review is to describe the prevalence of non-adherence to antihypertensive medications among hypertensive population in developing countries and identify factors associated with it. Methods: A literature search was conducted using the following scholarly electronic databases: Proquest, PubMed, JSTOR and Science Direct. The online search engine, Google Scholar was also used to search for and identify relevant papers. Peer-reviewed fulltext articles published in English on hypertensive adults in developing countries that measured adherence to antihypertensive medications and their associations with different factors were eligible for inclusion. The review followed the PRISMA reporting and analytical guidelines for systematic reviews. Results: In all, 42 studies conducted across 19 developing countries were selected for the review. The mean prevalence of medication non-adherence (MNA) among the select hypertensive population was 47.34%. Very few studies were conducted in community settings and except for one, no study examined gender differences in MNA factors. The analysis revealed a range of factors that can influence MNA including low household income and socioeconomic status; knowledge and beliefs of hypertension and its management; avoiding side effects of medications; cost of medication; use of herbal preparations; absence of symptoms; irregular follow-up; and dissatisfaction with the treatment and health services provided. There was a general lack of consideration of role of health system in health care delivery, self-efficacy, cultural barriers, per- There was also a lack of gender-specific research which is necessary at community settings given the social and economic vulnerabilities faced by women in developing countries that may affect adherence to antihypertensive medications. Conclusions: Future research in developing countries should consider individual risk perceptions, cultural barriers, gender and the role of local health system in health care delivery when assessing MNA among hypertensive population at community settings.

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Section: Demographic Factorsmentioning

confidence: 86%

Section: Mmas 4 Ethiopia; N = 384 Open Journal Of Epidemiologymentioning

confidence: 90%

Section: Mmas 4 Ethiopia; N = 384 Open Journal Of Epidemiologymentioning

confidence: 99%

Section: Treatment And/or Disease Related Factorsmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of Factors Influencing Medication Adherence to Hypertension Treatment in Developing Countries

Dhar¹,

Dantas²,

Ali³

2017

OJEpi

View full text Add to dashboard Cite

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“…About 80% of this burden occurred in low-and middle-income countries 5,6 . The levels of awareness, treatment and control of hypertension vary between countries and are particularly low in some economically developing countries.…”

mentioning

confidence: 99%

Untitled

2017

IJPSR

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Background: The objective of this study was to assess drug therapy problems (DTPs) and their predictors among hypertensive patients on follow up at Dil-Chora Referral Hospital, Ethiopia. Methods: Hospital based cross-sectional study involving medical record review was conducted from February-to-April 2015 using a structured questionnaire and this was complemented by a face-to-face interview. Adult hypertensive patients aged ≥18 years who were on follow-up for at least 3-months were enrolled in the study using a convenient sampling method. Data analysis was done using SPSS software version 16.0. Multiple logistic regressions were fitted and odds ratios with 95%CI were calculated to identify factors associated with DTPs. Results: The study included 271 hypertensive patients. Mean age was 57.73±12.13. One hundred sixty three (60.1%) were females. More than half of the respondents (50.6%) had comorbid condition and diabetes was the most common. More than 71% of patients were found to have at least one DTP and the mean number of DTPs per patient was 1.39±1.28. Need additional drug therapy(62.4%) and non-adherence(32.8%) were the two most common DTPs. Presence of comorbidity (AOR=5.74, 95%CI; 2.49-13.00), taking ≥3 medications per day (AOR=7.04, 95%CI; 2.33-21.25), and uncontrolled blood pressure (BP) (AOR=7.68, 95%CI; 3.70-15.90) were factors associated with DTPs. Conclusions: DTPs are common among hypertensive patients on follow up and the most common were need additional drug therapy and non-adherence to medications. Pharmacist interventions in drug therapy would help physicians in early identification and prevention of DTPs so that a joint effort between physicians and pharmacists should be made.

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