Medication Adherence to Specific Drug Classes in Chronic Heart Failure

Viana, Marta; Laszczyńska, Olga; Mendes, Sandra; Friões, Fernando; Lourenço, Patrícia; Bettencourt, Paulo; Lunet, Nuno; Azevedo, Ana

doi:10.18553/jmcp.2014.20.10.1018

Cited by 47 publications

(53 citation statements)

References 36 publications

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“…Prior studies of patients with various manifestations of cardiovascular disease have suggested that the prevalence of medication adherence varies depending on the specific medications assessed, 18,46,47 which is consistent with our results. These findings may be due to the differences in the costs, the side effects, and the frequency needed to be taken daily of each medication.…”

Section: Research Implicationssupporting

confidence: 92%

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Adherence to evidence-based secondary prevention pharmacotherapy in patients after an acute coronary syndrome: A systematic review

et al. 2015

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Section: Research Implicationssupporting

confidence: 92%

“…These findings may be due to the differences in the costs, the side effects, and the frequency needed to be taken daily of each medication. 46 Future studies measuring medication adherence should specify the drug class being analyzed.…”

Section: Research Implicationsmentioning

confidence: 99%

Adherence to evidence-based secondary prevention pharmacotherapy in patients after an acute coronary syndrome: A systematic review

et al. 2015

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“…Further research is needed in an adequately powered sample of persons of color that includes non-English-speaking individuals and those with low literacy, groups which were not adequately represented in the present study. In this study, measurement of adherence was limited to one medication, and new data suggest that some subtle differences exist in the adherence to various HF medicines (Viana et al, 2014). These data were collected before this article was published, but future studies should monitor a single drug class in all participants or preferably all the major drugs in the regimen.…”

Section: Discussionmentioning

confidence: 99%

Predictors of medication nonadherence differ among black and white patients with heart failure

2015

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Heart failure (HF) is a global public health problem, and outcomes remain poor, especially among ethnic minority populations. Medication adherence can improve heart failure outcomes but is notoriously low. The purpose of this secondary analysis of data from a prospective cohort comparison study of adults with heart failure was to explore differences in predictors of medication nonadherence by racial group (Black vs. White) in 212 adults with heart failure. Adaptive modeling analytic methods were used to model HF patient medication nonadherence separately for Black (31.7%) and White (68.3%) participants in order to investigate differences between these two racial groups. Of the 63 Black participants, 33.3% had low medication adherence, compared to 27.5% of the 149 White participants. Among Blacks, 16 risk factors were related to adherence in bivariate analyses; four of these (more comorbidities, lower serum sodium, higher systolic blood pressure, and use of fewer activities compensating for forgetfulness) jointly predicted nonadherence. In the multiple risk factor model, the number of risk factors in Black patients ranged from 0 to 4, and 76.2% had at least one risk factor. The estimated odds ratio for medication nonadherence was increased 9.34 times with each additional risk factor. Among White participants, five risk factors were related to adherence in bivariate analyses; one of these (older age) explained the individual effects of the other four. Because Blacks with HF have different and more risk factors than Whites for low medication adherence, interventions are needed that address unique risk factors among Black patients with HF.

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“…Так по данным исследования Viana M. и соавт. пациенты с хро-нической сердечной недостаточностью наиболее при-вержены к терапии ингибиторами АПФ, а наименее -к приему петлевых диуретиков, приверженность к бета-адреноблокаторам занимает промежуточное по-ложение между обозначенными позициями [14]. Ре-зультаты исследования de Vries S.T.…”

Section: The Problem Of Adherence In Modern Medicine проблема привержunclassified

The Problem of Adherence to the Treatment in Modern Medicine: Possibilities of Solution, Impact on the Effectiveness of Therapy and Disease Outcomes

Lukina¹,

Кутишенко²,

Martsevich³

2017

Racionalʹnaâ farmakoterapiâ v kardiologii

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Национальный медицинский исследовательский центр профилактической медицины Россия, 101990, Москва, Петроверигский пер., 10Проблема приверженности остается одной из актуальных, и при этом наиболее сложно решаемых для современных медицины и общества. Несмотря на пять десятилетий научного исследования данной проблемы, многочисленные попытки создания надежных диагностических те-стов, поиск методов повышения приверженности пациентов к выполнению врачебных рекомендаций, тем не менее, большая часть вопро-сов по данной тематике так и остается без ответов. Приверженность является доказанным фактором, в значительной степени влияющим на эффективность лечения и исходы заболевания. В статье рассматриваются некоторые причины, объясняющие отсутствие значимых проры-вов в данном направлении: (1) нерешенные вопросы с терминологией, особенно дефицит русскоязычных терминов, отсутствие как едино-го определения «приверженности», в котором бы учитывалось многообразие включаемых в него аспектов, так и общепринятой классифи-кации терминов по проблеме; (2) дефицит надежных диагностических тестов, удобных для применения в клинической практике, и отсут-ствие метода «золотого стандарта» диагностики приверженности; (3) неимение валидных тестов диагностики приверженности врачей к вы-полнению клинических рекомендаций и официальных инструкций к лекарственным средствам, а также тестов для оценки качества терапии; (4) значительное и постоянно растущее число идентифицированных факторов, которые оказывают влияние на приверженность, и обычно не учитываемое взаимовлияние этих факторов; (5) частое непринятие во внимание факта, что у одних и тех же пациентов может быть раз-ная приверженность к различным лекарственным препаратам, и т.д. Кроме того, обозначаются возможные перспективы для будущих исследований, в частности, необходимости оценки приверженности в неразрывной связке с контролем качества назначаемого лечения, а также важности комплексного воздействия на все или хотя бы на большинство факторов и аспектов приверженности, определенных на сегодняшний день. The problem of adherence remains one of the currently important and at the same time the most difficult one to solve for modern medicine and society. Despite five decades of scientific research on this issue, numerous attempts to create reliable diagnostic tests, the search for methods to increase patient adherence to the medical recommendations, nevertheless, most of the questions on this topic remain unanswered. Adherence is a proven factor that greatly influences the effectiveness of treatment and the outcomes of the disease. The article discusses some reasons explaining the absence of significant breakthroughs in solving the problem of adherence: (1) unresolved issues with terminology, especially the lack of Russian-language terms, the absence of both a uniform definition of "adherence", which takes into account the variety of aspects included in it and a generally accepted classification of terms by the topic; (2) a lack of reliable diagnostic tests that are convenient for clinical practice...

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Medication Adherence to Specific Drug Classes in Chronic Heart Failure

Cited by 47 publications

References 36 publications

Adherence to evidence-based secondary prevention pharmacotherapy in patients after an acute coronary syndrome: A systematic review

Adherence to evidence-based secondary prevention pharmacotherapy in patients after an acute coronary syndrome: A systematic review

Predictors of medication nonadherence differ among black and white patients with heart failure

The Problem of Adherence to the Treatment in Modern Medicine: Possibilities of Solution, Impact on the Effectiveness of Therapy and Disease Outcomes

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