Medication and orthodontic tooth movement

Abstract

As any pharmaceutical substance may influence the events associated with orthodontic tooth movement, it is of importance for the clinician to be able to recognize any prospective patient’s history and patterns of medicinal consumption. This review presents the effects of various commonly prescribed medications on the rate of orthodontic tooth movement. The article concludes that it remains, to a degree, unclear which types of medication may have a clinically significant effect in everyday clinical scenarios. However, since both prescription and over-the-counter medication use have recently increased significantly among all age groups, good practice suggests that it is important to identify patients consuming medications and consider the possible implications in orthodontic therapy.

Could medications and biologic factors affect post‐orthodontic tooth movement changes? A systematic review of animal studies

“…Pharmaceutical and other substances may have an impact on the signalling processes that are associated with bone remodelling pathways associated with orthodontic tooth movement and relapse phenomena 18,19 . Medicinal administration has been shown to affect tooth movement both in animals and humans 20‐24 . On the basis of the findings of the present review of animal studies, it may be said that the administration of specific substances may have an effect on the rate of relapse.…”

“…18,19 Medicinal administration has been shown to affect tooth movement both in animals and humans. [20][21][22][23][24] On the basis of the findings of the present review of animal studies, it may be said that the administration of specific substances may have an effect on the rate of relapse. Since information concerning the most appropriate retention strategy is still not complete, 52,53 the orthodontist should be knowledgeable about medications and biologic factors that may affect tooth movement in patients who have completed their orthodontic treatment and are in the phase of retention.…”

“…As orthodontic tooth movement can be modulated by any substance administered that can have effects on the molecular pathways involved, 18,19 the potential impact of different medications on the rate of orthodontic tooth movement has been systematically reviewed previously, and various effects have been shown in animals 20‐23 . Effects in human subjects have also been documented 24,25 .…”

“…[13][14][15][16][17] As orthodontic tooth movement can be modulated by any substance administered that can have effects on the molecular pathways involved, 18,19 the potential impact of different medications on the rate of orthodontic tooth movement has been systematically reviewed previously, and various effects have been shown in animals. [20][21][22][23] Effects in human subjects have also been documented. 24,25 To the best of our knowledge, there has not been any systematic review comprehensively elaborating the potential effect of medications and other biologic factors on the rate of relapse following active orthodontic tooth movement, as the available studies have not managed to identify and appraise all the pertinent information.…”

Do analgesics used for the pain experienced after orthodontic procedures affect tooth movement rate? A systematic review based on animal studies

“…Although only a small proportion consider this painful feeling to be significant and a minority will interrupt orthodontic treatment because of it, using analgesics for a few days to relieve this pain is common . Since any medication taken may impact the biochemical processes leading to orthodontic tooth movement, a thorough understanding of their effects is necessary . Current information originating from human trials regarding the effect of analgesics is limited to two studies, investigating the non‐steroidal anti‐inflammatory drugs nabumetone and tenoxicam …”