Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial

Aman, Michael G.; McDougle, Christopher J.; Scahill, Lawrence; Handen, Benjamin L.; Arnold, L. Eugene; Johnson, Cynthia R.; Stigler, Kimberly A.; Bearss, Karen; Butter, Eric; Swiezy, Naomi B.; Sukhodolsky, Denis G.; Ramadan, Yaser; Pozdol, Stacie L.; Nikolov, Roumen; Lecavalier, Luc; Kohn, Arlene E.; Koenig, Kathleen; Hollway, Jill A.; Korzekwa, Patricia; Gavaletz, Allison; Mulick, James A.; Hall, Kristy L.; Dziura, James; Ritz, Louise; Trollinger, Stacie; Yu, Sunkyung; Vitiello, Benedetto; Wagner, Ann E.

doi:10.1097/chi.0b013e3181bfd669

Cited by 290 publications

(215 citation statements)

References 40 publications

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“…Finally, there are few studies that have directly and appropriately compared psychotropics with psychosocial interventions. For example, although an RCT by Aman et al 77 demonstrated that combining risperidone with training from parents produced better child outcomes than risperidone alone, the trial did not include a group that only received parent training.…”

Section: Autism Spectrum Disordersmentioning

confidence: 99%

Treatment of Psychopathology in People with Intellectual and other Disabilities

Sturmey

2012

Can J Psychiatry

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Objective: To review the psychosocial, pharmacological, and other treatments of psychopathology in people with intellectual disabilities (IDs), autism, and other developmental disabilities (DDs).Method: Systematic reviews and meta-analyses of psychosocial, pharmacological, and other treatments for people with DDs are reviewed. Results:There is strong evidence for applied behaviour analysis (ABA) and other behavioural treatments of some forms of psychopathology. There is little good evidence to support the effectiveness of cognitive-behavioural therapy, cognitive therapy, sensory interventions, and other forms of psychosocial interventions. Recently, more randomized controlled trials (RCTs) of psychopharmacology have been published, especially with people with autism spectrum disorders. Most RCTs were for externalizing behaviour problems, rather than for psychopathology. These RCTs offer only preliminary support for the effectiveness of pharmacotherapy. No evidence was found for the effectiveness of other biological treatments. Conclusions:Current research supports the use of ABA and other behavioural interventions for some forms of psychopathology. Evidence for the effectiveness of other interventions is limited or absent.

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Section: Autism Spectrum Disordersmentioning

confidence: 99%

Treatment of Psychopathology in People with Intellectual and other Disabilities

Sturmey

2012

Can J Psychiatry

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“…For example, Triple P has been modified for use with parents of children with ID (Stepping Stones Triple P; Plant & Sanders, 2007) and Parent-Child Interaction Therapy has been applied to parents of children with ID (Bagner & Eyberg, 2007). Other similar behavioral parent training programs have been designed and developed specifically for families of children with ID or autism spectrum disorder, such as Signposts for Better Behavior (Hudson et al, 2003) and the RUPP Parent Training program (Aman et al, 2009). Each of these intervention programs has produced meaningful reductions in child problem behavior.…”

Section: Parent Training Strategiesmentioning

confidence: 99%

Intellectual Disability and Developmental Risk: Promoting Intervention to Improve Child and Family Well‐Being

et al. 2017

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Initial intervention processes for children with intellectual disabilities (IDs) largely focused on direct efforts to impact core cognitive and academic deficits associated with the diagnosis. Recent research on risk processes in families of children with ID, however, has influenced new developmental system approaches to early intervention. Recent risk and resilience processes are reviewed that connect stress, family process, and the high rates of behavioral problems in children with ID that have substantial influence on child and family outcomes. These models are linked to emerging evidence-based intervention processes that focus on strategic parent skill training and mindfulness interventions that reduce parental stress and create indirect benefits for children's behavioral competencies. A family-focused developmental systems approach (M. J. Guralnick, 2011) is emphasized.

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“…AP reduce maladaptive behaviors, such as irritability, self-injury, stereotypies, and hyperactivity, in children and adolescents with ASD, and reduce irritability and aggressive behavior in children and adolescents with disruptive behavior disorder (DBD) (2).…”

Section: Introductionmentioning

confidence: 99%

Bone mineral density in male adolescents with autism spectrum disorders and disruptive behavior disorder with or without antipsychotic treatment

Roke

Harten

Buitelaar³

et al. 2012

European Journal of Endocrinology

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Objective: To investigate the long-term effects of antipsychotic (AP) treatment and AP-induced hyperprolactinemia on bone mineral density (BMD) and body composition in male adolescents with autism spectrum disorders (ASDs) and/or disruptive behavior disorder (DBD). Design: Physically healthy 10-to 20-year-old boys with ASD and/or DBD, chronically treated (nZ56; mean 52 months, range 16-126 months) or not treated (nZ47) with an AP, were recruited to this observational study. Prolactin levels and biochemical bone parameters were measured and BMD of the lumbar spine and total body, and body composition were assessed by dual-energy X-ray absorptiometry, and volumetric BMD of the lumbar spine calculated. Group differences were tested with Student's t-test, c 2 test, Fisher exact test, and logistic regression analysis. Results: Forty-nine percent of the boys treated with an AP had hyperprolactinemia. The mean volumetric lumbar spine BMD z-score was lower (PZ0.043), the total percentage of body fat z-score was higher (PZ0.042), and biochemical bone marker carboxyterminal cross-linking telopeptide of bone collagen was lower in the AP-treated boys with hyperprolactinemia than in the AP-treated boys without hyperprolactinemia. Seven to 11% of the hyperprolactinemic boys had low BMD. The mean lumbar spine and total body BMD z-scores and body composition were similar in the boys who were or were not treated with an AP. The total study population had a lower mean lean tissue mass (mean z-score K0.37, PZ0.004) and a higher percentage of total body fat (mean z-score 1.16, P!0.001) than healthy controls (normative data); biochemical bone parameters were within normal limits. Conclusion: AP-induced hyperprolactinemia in boys with ASD or DBD may have a negative effect on lumbar spine BMD. Longitudinal studies are needed to confirm this finding and further disentangle the effects of the disorder, lifestyle, treatment, and hyperprolactinemia.

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Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial

Cited by 290 publications

References 40 publications

Treatment of Psychopathology in People with Intellectual and other Disabilities

Treatment of Psychopathology in People with Intellectual and other Disabilities

Intellectual Disability and Developmental Risk: Promoting Intervention to Improve Child and Family Well‐Being

Bone mineral density in male adolescents with autism spectrum disorders and disruptive behavior disorder with or without antipsychotic treatment

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