Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science

Granger, Douglas A.; Hibel, Leah C.; Fortunato, Christine; Kapelewski, Christine H.

doi:10.1016/j.psyneuen.2009.06.017

Cited by 261 publications

(199 citation statements)

References 46 publications

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“…In order to minimize the risk of food residue that can change salivary pH or composition 11,12 , participants who have eaten within 1 hr should rinse their mouth with a small amount of water prior to providing a specimen. Consideration of access to food and drink should be carefully planned in the study design.…”

Section: Discussionmentioning

confidence: 99%

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Hodgson

2013

JoVE

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Salivary measures have emerged in bio-behavioral research that are easy-to-collect, minimally invasive, and relatively inexpensive biologic markers of stress. This article we present the steps for collection and analysis of two salivary assays in research with frail, community residing older adults-salivary cortisol and salivary alpha amylase. The field of salivary bioscience is rapidly advancing and the purpose of this presentation is to provide an update on the developments for investigators interested in integrating these measures into research on aging. Strategies are presented for instructing family caregivers in collecting saliva in the home, and for conducting laboratory analyses of salivary analytes that have demonstrated feasibility, high compliance, and yield quality specimens. The protocol for sample collection includes: (1) consistent use of collection materials; (2) standardized methods that promote adherence and minimize subject burden; and (3) procedures for controlling certain confounding agents. We also provide strategies for laboratory analyses include: (1) saliva handling and processing; (2) salivary cortisol and salivary alpha amylase assay procedures; and (3) analytic considerations. Video LinkThe video component of this article can be found at

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Section: Discussionmentioning

confidence: 99%

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Hodgson

2013

JoVE

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“…This included timing the participant for two minutes with the salivette under their tongue and calling back 30 min later for the second collection. At each saliva collection, research staff assessed medication intake and strenuous physical activity within the past 12 h. Other than over-thecounter aspirin or acetaminophen, there were no reports of contraindicating medications (Granger et al, 2009). After two days of saliva collection, participants brought their frozen samples to their assessment appointment.…”

Section: Salivary Cortisolmentioning

confidence: 99%

Effects of written disclosure on psychophysiological stress among parents of children with autism: A randomized controlled pilot study

Paz

Wallander

Tiemensma

2018

Research in Autism Spectrum Disorders

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“…The subjects had to remove the swab and gently chew for 2 min. The collection of the sample had to be at least 1 h after taking food or drink and having brushed their teeth (16). The swab was then placed in a container inside the tube.…”

Section: Sc Collection and Assaymentioning

confidence: 99%

Usefulness of salivary cortisol in the diagnosis of hypercortisolism: comparison with serum and urinary cortisol

Manetti¹,

Rossi²,

Grasso³

et al. 2013

European Journal of Endocrinology

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Objective: Several tests have been proposed to diagnose patients with Cushing's syndrome (CS). The aims of the study were: i) to evaluate the performance of salivary cortisol (SC) in hypercortisolism and ii) to compare SC with serum cortisol (SeC) and urinary cortisol. Design and patients: This was a diagnostic study. Twenty-seven patients with untreated Cushing's disease (CD untr), 21 women consuming oral contraceptive pill (OCP), 18 pregnant women, and 89 healthy subjects (controls) were enrolled. Methods: SC and SeC at baseline and after the low-dose dexamethasone suppression test (LDDST) and urinary free cortisol (UFC) were measured. Results: Midnight SC had a sensitivity of 100% in the CD untr group and a specificity of 97.7% in the controls. Specificity remained high (95.2%) in women taking OCP, while in pregnant women, it decreased to 83.3%. SC after the LDDST showed a sensitivity of 96.3% in the CD untr group; specificity was 97.7% in the controls and 90.5% in OCP women. Midnight SeC had a sensitivity of 100% in the CD untr group. SeC after the LDDST had a sensitivity of 100% in the CD untr group while specificity was 97.7% in the controls and 61.9% in women taking OCP. For UFC, sensitivity was 92.6% in the CD untr group while specificity was 97.7% in the controls and 100% in the OCP group. Conclusions: SC is a reliable parameter for the diagnosis of severe hypercortisolism, with high sensitivity and specificity. In women during pregnancy or taking OCP, the measurement of SC, identifying the free fraction, could be helpful to exclude CS.

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Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science

Cited by 261 publications

References 46 publications

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

Effects of written disclosure on psychophysiological stress among parents of children with autism: A randomized controlled pilot study

Usefulness of salivary cortisol in the diagnosis of hypercortisolism: comparison with serum and urinary cortisol

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