Medication-induced esophagitis

Agha, Farooq P.; Wilson, Joanne A. P.; Nostrand, Timothy T.

doi:10.1007/bf02035023

Cited by 29 publications

(10 citation statements)

References 26 publications

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“…Özofajit, 25-35 yaş arasında ve kadınlarda sık görülür. [7,11,13] Özofajit gelişiminde en sık rastlanan nedenler, olgumuzda olduğu gibi ilacın az suyla alınması ve alındıktan kısa süre sonra yatılmasıdır. [5,7,11,12] İlaç kullanımına bağlı gelişen özofajitin tipik klinik belirtisi saatler veya günler içerisinde gelişen retrosternal yanma, disfaji ve odinofajidir.…”

Section: Discussionunclassified

“…[7,11] Doksisikline bağlı özofajitlerin büyük bir kısmında, hasarın özo-fagusun orta üçte birlik bölümünde gözlendiği bildirilmiştir. [7,[11][12][13] Hastamızda da ülserler özofagusun orta üçte birlik bölümünde saptanmıştır. İlaca bağlı özofajitlerin en sık rastlanan endoskopik bulgusu; tek veya birden fazla sayıda, ayrı ayrı veya kümeleşme eğilimi gösteren yüzeyel ülserlerdir.…”

Section: Discussionunclassified

“…[10,13] Sukralfatın hasarlı mukoza, nekrotik doku ve ülserlerde mukozal rejenerasyonu ve prostoglandin salınımını uyardığı gösterilmiştir. [8] Hastamızın kullandığı doksisiklin kesilmiş ve özofajitin tekrarlama olasılığı nedeniyle, bundan sonra doksisiklin kullanmaması öne-rilmiştir.…”

Section: Discussionunclassified

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Tek doz Doksisiklin kullanımına bağlı gelişen özofagus ülseri: Bir olgu sunumu

Ataseven¹,

Kutlu²,

Sayin³

et al. 2014

Turk J Fam Pract

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İlaca bağlı özofagus ülseri literatürde sık görülmemekle birlikte yol açabileceği komplikasyonlar açısından önemlidir. Doksisiklin yeterli miktarda su ile alınmaz ise veya alındıktan kısa süre sonra yatılırsa özofagusta mukozal hasara neden olur. Bu olguda akne nedeniyle doksisiklin tedavisi başlanmış 24 yaşındaki kadın hasta sunuldu. Hasta ilacın ilk dozundan sonra retrosternal yanma, disfaji semptomlarıyla başvurdu. Yapılan üst gastrointestinal sistem endoskopisinde özofagus 1/3 orta bölümünde 2 santimetrelik bir segmentte yüzeyel ülserasyonlar görüldü. Anamnez ve endoskopik bulgularla, hastaya doksisiklin kullanımına bağlı ilaç özofajiti teşhisi konuldu. Doksisiklin tedavisi ve oral alımı kesildi. İntravenöz sıvı tedavisi, sukralfat ve lansoprazol tedavisi başlandı. İlerleyen günlerde hastanın şikâyetleri azalarak kayboldu. Olgumuzda olduğu gibi, ilacın süresinden bağımsız olarak tek doz kullanım sonrasında dahi özofageal ülser gelişebilmektedir.

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Section: Discussionunclassified

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Tek doz Doksisiklin kullanımına bağlı gelişen özofagus ülseri: Bir olgu sunumu

Ataseven¹,

Kutlu²,

Sayin³

et al. 2014

Turk J Fam Pract

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“…There is usually a sudden onset of dysphagia (20%), accompanied by retrosternal chest pain [ 19,20]. However, sometimes the association with medications is not identified initially.…”

Section: Medication-induced Esophageal Injury (Tables 4 5 and 6)mentioning

confidence: 98%

Drug-induced dysphagia

1993

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Dysphagia describes the disability or problems in swallowing a wet or dry bolus properly and is normally associated with an impaired transport of the bolus. Dysphagia can be accompanied by a pain sensation in the chest mostly caused by impaction of the food bolus in the esophagus. Odynophagia describes only the status of painful swallowing without an impairment of the swallow and transport function. Drug-induced dysphagia can be caused in two different ways. First as a normal drug side effect of the pharmacological action of the drug or as a complication of the therapeutic action of the drug. The normal drug side effect is most likely in drugs that affect smooth or striated muscle function or the sensitivity of the mucosa. The drug effect on smooth muscle function that causes dysphagia can be inhibitory or excitatory. Dysphagia is a common clinical symptom in patients with reduced perception of the pharyngeal mucosa which leads to an subjective impairment of swallowing. Dysphagia caused by a complication of the therapeutic action of a drug includes viral or fungal esophagitis in patients treated with immunosuppressive drugs or cancer therapeutic agents, or antibiotics and immunological reactions to certain drugs such as erythema exsudativa multiforme or Stevens-Johnson syndrome. Second, drug-induced dysphagia can be due to medication-induced esophageal injury (MIEI). In most cases this mucosal injury appears to be the direct result of prolonged contact of a potentially caustic drug with the esophageal mucosa. This form of medication-induced esophagitis is most likely to be found in elderly patients and patients with esophageal motility disorders.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…There is a sudden onset of dysphagia (20 %), accompanied by retrosternal chest pain (72 %) or odynophagia (74 %) within 4 -12 hrs after ingestion of the drug. 16,17 However, sometimes the association with drugs is not identified initially. The most common site of esophageal injury is near the level of the aortic arch, an area characterized by external compression from the arch itself, transition from skeletal to smooth muscle, and by physiological reduction in the amplitude of the esophageal peristaltic wave.…”

Section: Drug-induced Esophageal Injurymentioning

confidence: 99%

Drug-Induced Dysphagia

Alshehri

2003

Ann Saudi Med

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AM Al-Shehri, Drug-Induced Dysphagia. 2003; 23(5): 249-253 Dysphagia is related to the impairment of food passage from the mouth to the stomach. It describes disability or problems in swallowing a wet or dry bolus properly. Dysphagia can be accompanied by a pain sensation in the chest, mostly caused by impaction of the food bolus in the esophagus. Dysphagia should not be confused with the globus sensation (globus hystericus), a feeling of having a lump in the throat, which is unrelated to swallowing and occurs without impaired transport.Structural lesions of the cervical spine such as diffuse idiopathic skeletal hyperostosis are rare causes of dysphagia. Dysphagia following anterior cervical fusion as well as globus and dysphonia due to dysfunction of the vertebral joints are more likely. Symptoms during swallowing of fluids indicate a neurogenic origin. Discoordinated swallowing, nasal reflux, dysphonia or general weakness may also occur.1 Chronic aspiration with respiratory compromise is the main consequence in a variety of neurological disorders as well as in cases of postsurgical dysphagia. Relaxation of the upper esophageal sphincter indicates coordinated muscle movement between the pharynx and esophagus. Dysfunction of the pharyngoesophageal segment may lead to cricopharyngeal achalasia. A dyskinetic sphincter commonly represents an extrapharyngeal cause, i.e., disease associated with gastroesophageal reflux.2 Disorders of the esophageal phase of deglutition can produce retrosternal pain, heartburn, regurgitation and vomiting, as well as laryngeal and respiratory signs. Esophageal motility disorders include lower achalasia, tumors, peptic strictures, inflammatory diseases, drug-induced ulcers, rings and webs.3 Motility disorders present with aperistaltic, spontaneous contractions, diffuse esophagospasm, or a hypermotile esophagus. Gastroesophageal reflux with esophagitis must always be excluded, especially in patients with a globus sensation. 2The diagnosis of dysphagia is based upon a careful history, clinical examination, endoscopy, dynamic imaging (videofluoroscopy, cinematography, videosonography) and electrophysiologic procedures (including pharyngoesophageal manometry, electromyography and pH determinations). 1,4 The multiple features of the appearance of the symptoms of dysphagia and globus make a multidisciplinary approach necessary to establish a diagnosis and begin effective treatment. The evaluation of a patient with symptoms of dysphagia involves two principal aspects: determining the functional level of swallowing ability and the etiology of the swallowing disorder. In long-term care facilities, patients generally present with dysphagia symptoms related to established chronic medical conditions. Whether new symptoms of swallowing dysfunction are caused by an emerging medical problem or by progression of a previously identified disease process is a secondary issue in the long-term care environment; the crucial questions relate to quality of life, requirements for daily nutrition and care, an...

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Medication-induced esophagitis

Cited by 29 publications

References 26 publications

Tek doz Doksisiklin kullanımına bağlı gelişen özofagus ülseri: Bir olgu sunumu

Tek doz Doksisiklin kullanımına bağlı gelişen özofagus ülseri: Bir olgu sunumu

Drug-induced dysphagia

Drug-Induced Dysphagia

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