Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab—a review

New therapeutic opportunities for COVID-19 patients with Tocilizumab: Possible correlation of interleukin-6 receptor inhibitors with osteonecrosis of the jaws

“…After a literature research, we highlighted a possible correlation between tocilizumab and medication-related osteonecrosis of the jaws (MRONJ), an infectious complication of antiresorptive and antiangiogenic drugs. In a recent review on MRONJ unrelated to bisphosphonates and denosumab, a wide range of medications classified as tyrosine kinase inhibitors, monoclonal antibodies, mammalian target of rapamycin inhibitors, radiopharmaceuticals, selective estrogen receptor modulators, and immunosuppressants have been implicated in MRONJ, but tocilizumab is not reported [9].…”

Preventing medication-related osteonecrosis of the jaw

“…Cases of jaw osteonecrosis have been reported with other drugs, but these are rare and the magnitude of risk is uncertain 14. The US Food and Drug Administration (FDA) has linked several cases to mammalian target of rapamycin (m-TOR) inhibitors (everolimus and temsirolimus) used in renal cell cancer 15.…”

A Case of Intra-Oral Bone Exposure of the Hard Palate: A Clinical Diagnostic Dilemma

“…Osteonecrosis or aseptic and avascular necrosis of the jaws (ONJ), has been defined as an area of intra-oral and/or extra-oral exposed bone and may result in significant patient morbidity. In the last period osteonecrosis of the jaws related to Bisphosphonate (BRONJ) and, recently, Denosumab related osteonecrosis of the jaws (DRONJ) and other medicaments such as antiangiogenic agents (MRONJ) have been abundantly reported [1], but different etiologies may cause a maxillomandibular osteonecrosis. In the present report we describe the case of a patient affected by Crohn's Disease referred to Department of Biomedical and Neuromotor Sciences, unit of Oral Medicine, University of Bologna on September 2108 for the presence of a painful lesion in the hard palate.…”