Medicinal, biological and phytochemical properties of Gentiana species

Mirzaee, Fatemeh; Hosseini, Amirsaeed; Jouybari, Hossein Bakhshi; Davoodi, Ali; Azadbakht, Mohammad

doi:10.1016/j.jtcme.2016.12.013

Cited by 88 publications

(68 citation statements)

References 39 publications

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“…Genus Gentiana is one of the largest groups in Gentianaceae, comprising 360 species that are widespread across Northwest of Africa, Europe, America, East of Australia, and Asia [1]. Many species of this genus have significant economic value and they are widely used by the food and pharmaceutical industries in the world [2][3][4]. In Europe, G. lutea (Yellow Gentian) are traditional materials for alcoholic bitter beverages and have a function of being appetite stimulating and improving digestion [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…In Europe, G. lutea (Yellow Gentian) are traditional materials for alcoholic bitter beverages and have a function of being appetite stimulating and improving digestion [4,5]. In Asia, Gentiana has a long history in use for medicine [2,3,6]. Places, including Iran, Mongolia, Japan and Korea have literature and details about nature and the of medicinal Gentiana plants found in these countries [3,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…In Asia, Gentiana has a long history in use for medicine [2,3,6]. Places, including Iran, Mongolia, Japan and Korea have literature and details about nature and the of medicinal Gentiana plants found in these countries [3,7,8]. In China, species of Gentiana are diverse (about 248 species) and some of them have been an important part of traditional Chinese medicine (TCM) for a long time [1,9].…”

Section: Introductionmentioning

confidence: 99%

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Discrimination of Gentiana and Its Related Species Using IR Spectroscopy Combined with Feature Selection and Stacked Generalization

Shen

Wang

2020

Molecules

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Gentiana, which is one of the largest genera of Gentianoideae, most of which had potential pharmaceutical value, and applied to local traditional medical treatment. Because of the phytochemical diversity and difference of bioactive compounds among species, which makes it crucial to accurately identify authentic Gentiana species. In this paper, the feasibility of using the infrared spectroscopy technique combined with chemometrics analysis to identify Gentiana and its related species was studied. A total of 180 batches of raw spectral fingerprints were obtained from 18 species of Gentiana and Tripterospermum by near-infrared (NIR: 10,000–4000 cm−1) and Fourier transform mid-infrared (MIR: 4000–600 cm−1) spectrum. Firstly, principal component analysis (PCA) was utilized to explore the natural grouping of the 180 samples. Secondly, random forests (RF), support vector machine (SVM), and K-nearest neighbors (KNN) models were built while using full spectra (including 1487 NIR variables and 1214 FT-MIR variables, respectively). The MIR-SVM model had a higher classification accuracy rate than the other models that were based on the results of the calibration sets and prediction sets. The five feature selection strategies, VIP (variable importance in the projection), Boruta, GARF (genetic algorithm combined with random forest), GASVM (genetic algorithm combined with support vector machine), and Venn diagram calculation, were used to reduce the dimensions of the data variable in order to further reduce numbers of variables for modeling. Finally, 101 NIR and 73 FT-MIR bands were selected as the feature variables, respectively. Thirdly, stacking models were built based on the optimal spectral dataset. Most of the stacking models performed better than the full spectra-based models. RF and SVM (as base learners), combined with the SVM meta-classifier, was the optimal stacked generalization strategy. For the SG-Ven-MIR-SVM model, the accuracy (ACC) of the calibration set and validation set were both 100%. Sensitivity (SE), specificity (SP), efficiency (EFF), Matthews correlation coefficient (MCC), and Cohen’s kappa coefficient (K) were all 1, which showed that the model had the optimal authenticity identification performance. Those parameters indicated that stacked generalization combined with feature selection is probably an important technique for improving the classification model predictive accuracy and avoid overfitting. The study result can provide a valuable reference for the safety and effectiveness of the clinical application of medicinal Gentiana.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Discrimination of Gentiana and Its Related Species Using IR Spectroscopy Combined with Feature Selection and Stacked Generalization

Shen

Wang

2020

Molecules

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“…Drugs of plant sources are frequently considered to be less toxic and almost free from adverse effects in conventional uses [4,5,6]. Mespilus germanica is a large shrub or small tree common in northern forest regions of Iran that grows to a height of 2–6 m. It is a member of the Rosaceae family and has very nutritive and therapeutic usages in Iran.…”

Section: Introductionmentioning

confidence: 99%

The Determination of Blood Glucose Lowering and Metabolic Effects of Mespilus germanica L. Hydroacetonic Extract on Streptozocin-Induced Diabetic Balb/c Mice

et al. 2018

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Background: The serum glucose lowering, normalization animal body weight, and antioxidative stress effects of Mespilus germanica L. leaf extract were investigated in normal and streptozotocin-induced Balb/C mice. Methods: The phenol and flavonoid of the leaves of M. germanica were extracted by percolation and concentrated using a rotary evaporator. Its total phenol and flavonoid content was determined using folin and aluminum chloride methods, respectively. The study was conducted on 48 matured male Balb/C mice (20–30 g) divided into 6 groups (n = 8). Diabetes mellitus was induced by single intraperitoneal injection of 35 mg/kg of streptozotocin (STZ). Extracts of Mespilus germanica were used orally at the dose of 50, 100, and 200 mg/kg body weight per day for 21 days. Results: Oral administrations of the M. germanica L. leaf extract significantly decreased serum glucose, oxidative stress, and lipid peroxidation and maintained animal body weight during treatment period (p < 0.05) compared to metformin (200 mg/kg) in over 100 mg/kg, 200 mg/kg, and 50 mg/kg dosages, respectively. Conclusions: The present study indicated that the Mespilus germanica leaf extract significantly decreased serum glucose and maintained normal body weight in Balb/C diabetic mice.

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“…The massive collection of plants as a medicinal material, which is the source of xanthones, destructively affects the species composition of natural phytocoenoses. Thus, the species of plants as sources of xanthones from the families Gentianaceae, Hypericaceae and others already have a rare and endangered status [2, 6,7]. Consequently, it is important to search for alternative sources of xanthones, which can be, for example, high-yielding plant tissues cultures in vitro.…”

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confidence: 99%

Determination of xanthones in plants and the nutrient medium under in vitro cultivation conditions

et al. 2018

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In recent years, xanthones have received considerable attention from scientists due to their biological activity: anticarcinogenic, antiviral, antibacterial, antioxidant, anti-inflammatory and other properties.Therefore they are useful for prevention and treatment of different diseases:cancer, Alzheimer's and Parkinson's disease, cardiovascular disorders, diabetes, etc. Extracts of different species of plants containing xanthones are components of chemotherapeutic and other medical drugs. In order to find the most sensitive and environmentally safe method of quantitative determination of xanthones in the plant material and the nutrient medium, known methods were tested and selected for the prototype Vyisochina G. I. et al., 2011 method, which uses ethanol as an extractor. As the plant material we used plants of different species that were grown under in vitro cultivation conditions on the agarized nutrient medium. This agarized nutrient medium was also used for the xanthone content analysis. Based on the performed research, modifications of the method for determining the content of xanthones were adapted to the in vitro conditions, which detail the specificity of extraction and quantitative calculation of the xanthone content in plant explants. Our own method of determination of these compounds in the agarized nutrient medium was developed as well. The method, that we proposed, will significantly speed up the process of xanthone detecting and will also increase their yield in biotechnological processes for obtaining the pharmacologically valuable secondary metabolites of phenolic nature.

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Medicinal, biological and phytochemical properties of Gentiana species

Cited by 88 publications

References 39 publications

Discrimination of Gentiana and Its Related Species Using IR Spectroscopy Combined with Feature Selection and Stacked Generalization

Discrimination of Gentiana and Its Related Species Using IR Spectroscopy Combined with Feature Selection and Stacked Generalization

The Determination of Blood Glucose Lowering and Metabolic Effects of Mespilus germanica L. Hydroacetonic Extract on Streptozocin-Induced Diabetic Balb/c Mice

Determination of xanthones in plants and the nutrient medium under in vitro cultivation conditions

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