Medicinal herbs and multiple sclerosis: Overview on the hard balance between new therapeutic strategy and occupational health risk

Costantini, Erica; Masciarelli, Eva; Casorri, Laura; Luigi, Marco Di; Reale, Marcella

doi:10.3389/fncel.2022.985943

Cited by 6 publications

(3 citation statements)

References 219 publications

(245 reference statements)

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“…MS development has been linked to smoking, stress, obesity, and low intake of vitamin D. The gut microbiome, infections, vaccinations, heavy metal exposure, and pesticide exposure are also risk factors for MS (Costantini et al, 2022).…”

Section: Epidemiology and Risk Factors Of Multiple Sclerosismentioning

confidence: 99%

“…The polyphenols obtained from Curcuma longa are curcumin, dimethoxycurcumin, and bisdemethoxycurcumin which function as antioxidants and protect the brain against a variety of oxidative stress (Pavlovic et al, 2023). They also have neuroprotective and anti-aging properties due to their ability to hunt down superoxide anions (Costantini et al, 2022). The rhizome of C. longa is well-known as turmeric which is used in cooking food.…”

Section: Curcuma Longamentioning

confidence: 99%

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Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Sajid,

Abbas,

Khan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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The phrase "neurodegenerative diseases" refers to conditions that cause a major loss of neurons, both structurally and functionally. Neurodegenerative diseases are serious life-threatening in which neural cells in the brain stop working or die. One of the most recently discovered pathogenic processes in the genesis of neurological illnesses is mitochondrial dysfunction. Mitochondria play a significant role in various cellular processes such as the production of ATP, intracellular calcium, and generation of reactive oxygen species and improper function leads to diseases. Oxidative stress and aging are two other prevalent etiologies of neurological diseases. Several side effects have emerged as a result of current treatment methods and the progressive nature of illnesses, prompting patients to switch to other medications. The helpful impact of medicinal plants in these situations has been attributed to their demonstration through several cellular and molecular processes. Traditional plants have a few neuroprotective mechanisms: they reduce inflammatory responses, regulate pro-inflammatory cytokines' functional aspects such as tumor growth, and enhance antioxidant qualities. Plant prevention strategies for these diseases heavily rely on variations in transcription and transduction pathways. Some of the therapeutic herbs for preventing neurological disorders are Panax ginseng, Curcuma longa, Zingiber officinale, Ginkgo biloba, and Utrica diocia, etc., have shown antioxidant as well as anti-inflammatory effects and also show a promising tool for treating neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, multiple sclerosis, and epilepsy. Medicinal plants contain various phytochemical constituents that improve oxidative stress, reduce mitochondrial damage, and protect against brain damage. In short, use of whole plants or parts of medicinal plants from roots to seeds extracted chemicals are used to prevent neurodegenerative illnesses.

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Section: Epidemiology and Risk Factors Of Multiple Sclerosismentioning

confidence: 99%

Section: Curcuma Longamentioning

confidence: 99%

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Sajid,

Abbas,

Khan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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“…Exposure to OPs leads to an increase in the release of proinflammatory mediators and a decrease in the release of anti-inflammatory cytokines. Additionally, OPs inhibit oxidative phosphorylation and produce a high concentration of ROS, which subsequently leads to mitochondrial dysfunction [91,92].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders

Amarjeet,

Babu,

Mohapatra

et al. 2023

Acta Neurologica Scandinavica

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Myelin is a spiral compilation of uniformly thick membranes around the axon in an alternating fashion, and it is formed by a complicated process known as myelination. Myelin sheaths are responsible for various physiological functions such as metabolism, rapid nerve conduction, and maintaining ionic and water homeostasis in the brain. Lipid is one of the major components in the myelin, which includes cholesterol, ceramide, and their derivatives, such as galactosylceramide, sulfatide, and gangliosides. Ceramide and its derivatives are synthesised by various ceramide biosynthetic pathways such as de novo, salvage, sphingomyelinase, and recycling of exogenous ceramide. At an appropriate level, ceramide facilitates the development of the nervous system, cell proliferation, autophagy, and apoptosis, which are responsible for normal functioning, but when the level is altered from normal, it results in mitochondrial dysfunction or cell death through autophagy and apoptosis. The ceramide level increases, especially in the mitochondria. Ceramide level increases in response to oxidative stress which is mediated by inflammatory cytokines. Due to mitochondrial dysfunction, an energy-deficient condition is created because of disruption in the electron transport chain, which results in the death of neurons and glial cells, which subsequently cause demyelination and degeneration of axon. Losing myelin while axons remain relatively intact is the characteristic feature of demyelinating diseases. The primary element of demyelinating disorder is damage, malfunction, failure, or death of mitochondria. These disturbances may occur due to direct or indirect interaction of ceramide with mitochondria. There are several risk factors for demyelination, such as viruses, bacteria, fungi, trauma, obesity, vitamin D deficiency, and genetic and environmental factors. Thus, the review is mainly aimed towards the interaction between ceramide and mitochondria during demyelination.

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The Effects of Coffee/Caffeine in Patients with Multiple Sclerosis; A Systematic Review

Salekzamani,

Baharomid,

Pakkhesal

et al. 2024

J Evid Based Complementary Altern Med

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Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Caffeine, as the most widely consumed psychoactive substance, has been suggested to have potential effects on the clinical course and disability levels of MS patients. This study aimed to review the current evidence on the effects of coffee/caffeine in patients with MS. Methods This study followed the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis and PRISMA 2020 statement. Clinical evidence regarding the effects of caffeine/coffee in MS patients was considered. A systematic search was performed in PubMed, Scopus, Web of Science, and Embase in October 2023, and updated via handsearching in March 2024. JBI's critical appraisal tools were utilized to scrutinize the risk of bias. Results Out of 297 screened records, eight studies were eventually found to meet our inclusion criteria. The sample size of the studies varied between 12 and 1372 and the study designs were retrospective cohort, RCT, single-blind crossover trial, single-arm pilot study (each one study), and cross-sectional (four studies). No significant association between the level of disability and coffee/caffeine intake has been reported, although it was reported to be associated with cognitive improvements. Discussion Evidence indicates an association between coffee/caffeine consumption, and improved cognitive outcomes in patients with MS, while there is no considerable relationship with the disease disability. Considering the limitations of the evidence, such as the small number of studies, and great diversity in study designs, the findings of this study should translate to clinical practice with caution.

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Medicinal herbs and multiple sclerosis: Overview on the hard balance between new therapeutic strategy and occupational health risk

Cited by 6 publications

References 219 publications

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders

The Effects of Coffee/Caffeine in Patients with Multiple Sclerosis; A Systematic Review

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