Medicinal plant ecology, knowledge and conservation in Kalimantan, Indonesia

Caniago, Izefri; Siebert, Stephen F.

doi:10.1007/bf02862141

Cited by 188 publications

(131 citation statements)

References 13 publications

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“…The indigenous knowledge base that is related to ethnobotany of the people in any area is important for keeping the present Intellectual Property Rights (IPR) regime in view and also preventing such knowledge from losing in the communities, as a result of rapid socio-economic and cultural changes. Similar information related to human plant interactions have been reported by many researchers over the world (Fanshawe, 1948a, b;Danks, 1945;Farnsworth et al, 1988;Johnston and Colquhoun, 1996;Hafeel and Shankar, 1999;Sajeev and Sashidharan, 1996;Rao, 1995;Caniago and Siebert, 1998;Olsen, 1998). Other studies from the Himalayan region also described the dependencies of the rural people on wild plants for subsistence needs (Maikhuri and Ramakrishnan, 1992;Farooquee and Saxena, 1996;Farooquee and Rao, 1998;Bhatt et al, 2000).…”

Section: Discussionsupporting

confidence: 64%

Interaction of Biodiversity and Economic Welfare - A Case Study from the Himalayas of India

Nautiyal

Rajan²,

Shibasaki³

2005

J ENV INFORM

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ABSTRACT. In any area to achieve the goal of biodiversity conservation, the existing resources must be strengthened, which are helpful to provide the alternate livelihood or income to the local people. However, although various programmes/policies are being set up over the world for conservation of biodiversity, a variety of factors are hurdles to achieve the expected goals. Particularly in developing countries the sustainable livelihood of the local perople is difficult if restrictions are imposed on their traditional usufruct rights over the natural resources. Based on the extensive field work and analysis of satellite imagery in the selected localities of the Indian Himalaya, we found that if the people are having the alternate avenue (profitable options) for earning, their dependencies on the existing resources (only to meet the subsistence needs, not for commercial purpose) will become much lower. Therefore, the biodiversity in these areas is conserved and managed in a healthy way. In this paper, the interactions of biodiversity and economic welfare of local people are discussed in view of understanding that the economic security is more important than pure enforcement of policies for biodiversity conservation.

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Section: Discussionsupporting

confidence: 64%

Interaction of Biodiversity and Economic Welfare - A Case Study from the Himalayas of India

Nautiyal

Rajan²,

Shibasaki³

2005

J ENV INFORM

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“…Investigating the Dayaks in Kalimantan, it is found that the existence of dukun is heavily interlinked with knowledge of medicinal herbs (Caniago & Siebert, 1998). Bernstein also writes of the dukun's prowess in providing traditional healing for diseases caused by one's body being entered by a spirit (Bernstein, 1993).…”

Section: Existing Understanding Of the Dukun Knowledge Abilities Anmentioning

confidence: 99%

Redefining The Term of Dukun

Sartini¹,

Ahimsa-Putra²

2017

Jur, Hum

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Dukun, wong pinter, and other terms, commonly constitutes to the term of shamanism, are often interpreted in the same way. In particular, the dukun and wong pinter are generally understood as persons who have extraordinary or even supernatural powers, are capable of communicating with spirits and understanding the unseen, can generally help resolve issues faced by members of their communities, including illnesses, spiritual disturbances, lost items, unfortunate fates, etc. They are also predicated to charge to the patient and even willing to help witchcraft to harm other people. In fact, not all shamans have negative behaviors. In Temanggung, Central Java, though this general understanding is still common, there is distinction in the specific details and characteristics of the dukun and wong pinter. Dukun are often understood negatively, meanwhile the wong pinter has more positive connotations. Because of the different principle meaning the both terms should not be generalized and used appropriately and wisely. Improper use can cause discomfort in the community, and academically the both term actually refers to a completely different subject characteristics.

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“…Therefore, a search for more effective DNMTi's from natural compounds is necessary. Indonesia is recognized for its biodiversity, with at least 9600 species known to possess pharmacological activity [18,19], so a search for a DNMTi is promising. A previous study conducted by Yanuar et al [20] collected three-dimensional data on several Indonesian herbal compounds and compiled a database, published as the Indonesian Herbal Database (HerbalDB).…”

Section: Introductionmentioning

confidence: 99%

Virtual Screening of Indonesian Herbal Database for Dna Methyltransferase Inhibitors

Bhaskarawilaputraka

Azminah

Erlina

et al. 2017

Asian J Pharm Clin Res

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Objective: DNA hypermethylation is an abnormal epigenetic process catalyzed by DNA methyltransferase 1 (DNMT1). It is also one of the factors that cause non-communicable diseases such as cancer, diabetes, and other metabolic diseases. DNA hypermethylation can be reversed by suppressing DNMT1 activity using a DNMT inhibitor. This study was conducted to seek out inhibitor candidates among natural products. Methods:The search for potential inhibitors was conducted through a virtual screening of the Indonesian Herbal Database using AutoDockVina as docking software. Twenty-five compounds known for their inhibitory activity against DNMT1 were used as actives and as a reference for generating decoys, which was done using the Directory of Useful Decoys, Enhanced. Results:The 12 compounds with binding energies below the cutoff value were cassiamin C (A1), procyanidin B2 (B2), ent-epicatechin-(4alpha->8)-ent-epicatechin (C3), epicatechin-(4beta->8)-epicatechin-3-O-gallate (D4), neorhusflavanone (E5), 3-O-galloylepicatechin-(4beta->6)-epicatechin-3-O-gallate (F6), withanolide (G7), 3-O-galloylepigallocatechin-(4beta->6)-epigallocatechin-3-O-gallate (H8), cyanidin 3-(6''-caffeylsophoroside)-5-glucoside (I9), epifriedelanol (J10), gallocatechin-(4alpha->8)-epicatechin (K11), and scutellarein 7-glucosyl-(1->4)-rhamnoside (L12). A1 had the lowest binding energy of −12.7 kcal/mol, whereas K11 had the highest of −11.5 kcal/mol. Conclusions:The virtual screening yielded five potential DNMT1 inhibitors: Procyanidin B2, ent-epicatechin-(4alpha->8)-ent-epicatechin, epicatechin-(4beta->8)-epicatechin-3-O-gallate, neorhusflavanone, and cyanidin 3-(6''-caffeylsophoroside)-5-glucoside.Keywords: Epigenetic, DNA methyltransferase inhibitor, Indonesian Herbal Database, Virtual screening, AutoDockVina. INTRODUCTIONEpigenetic modification is one of the factors that cause noncommunicable diseases. Living environment, lifestyle, exposure to toxic chemicals, and nutrition may influence an individual's epigenetic profile. Epigenetic modification can alter gene expression [1]. One type of epigenetic modification is DNA methylation. DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is the addition of a methyl (CH3) group to the DNA strand, specifically to the fifth carbon atom of a cytosine ring. Methylated cytosine, called 5-methylcytosine, usually occurs to a cytosine base that lies adjacent to a guanine base, at what is called a CpG site. The reason for this name is that cytosine is bonded to guanine through a phosphate bond. These sites normally occur in clusters; an area rich in CpG sites is called a CpG island. CpG islands are usually located near a gene regulator such as a promoter. DNA methylation that affects a gene promoter may repress the transcription of said gene and ultimately its expression. This process of turning a gene on and off through methylation is part of normal eukaryotic cell function [2,3].There are several types of DNMTs. Based on their functions, they can be grouped into two categories: De novo DNMTs...

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Medicinal plant ecology, knowledge and conservation in Kalimantan, Indonesia

Cited by 188 publications

References 13 publications

Interaction of Biodiversity and Economic Welfare - A Case Study from the Himalayas of India

Interaction of Biodiversity and Economic Welfare - A Case Study from the Himalayas of India

Redefining The Term of Dukun

Virtual Screening of Indonesian Herbal Database for Dna Methyltransferase Inhibitors

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