Medicinal plants: A potential source of novel bioactive compounds showing antimicrobial efficacy against pathogens infecting hair and scalp

Rajput, Minakshi; Kumar, Navneet

doi:10.1016/j.genrep.2020.100879

Cited by 17 publications

(11 citation statements)

References 64 publications

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“…Many underdeveloped nations around the world, especially those from rural areas, have access to affordable and readily available medications owing to wild plants [ 12 ], which are considered valuable sources of molecules with therapeutic potential [ 55 ]. This therapeutic potential is due to the presence of diverse bioactive constituents known as secondary metabolites that possess different mechanisms of action [ 56 ]. These secondary metabolites greatly influence the biological effects of therapeutic plants, such as their hypoglycaemic, anti-diabetic, anti-oxidant, anti-microbial, anti-inflammatory, anti-carcinogenic, anti-malarial, anti-cholinergic, and anti-leprosy activities [ 57 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Corchorus tridens L.: A Review of Its Botany, Phytochemistry, Nutritional Content and Pharmacological Properties

Kudumela,

Ramadwa,

Mametja

et al. 2024

Plants

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Phytotherapy is a cost-effective alternative that continues to evolve. This has sparked significant research interest in naturally occurring compounds found in edible plants that possess antibacterial, antioxidant, and anticancer properties. Corchorus tridens L. is a wild edible plant widely recognised for its edible leaves, which are used for vegetable and animal feed. The plant is widely distributed across the African continent and is utilised in numerous countries for treating fever, pain, inflammation, and sexually transmitted diseases. Extracts from various parts of this plant exhibit antimicrobial, antioxidant, and pesticidal properties. This plant is a rich source of amino acids, vitamins, essential fatty acids, proteins, and minerals, as well as secondary metabolites such as alkaloids, flavonoids, quinines, steroids, terpenoids, phenols, and tannins. Additional studies are still needed to determine other biological activities, such as anti-inflammatory activity, involvement in the treatment of measles, prevention of anaemia, and pain-relieving properties. The current review aims to provide information on the characteristics, distribution, nutritional content, bioactive compounds, traditional uses, and biological activities of the edible plant species C. tridens L. to stimulate further research interest to address the existing literature gaps concerning this plant.

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Section: Biological Activitiesmentioning

confidence: 99%

Corchorus tridens L.: A Review of Its Botany, Phytochemistry, Nutritional Content and Pharmacological Properties

Kudumela,

Ramadwa,

Mametja

et al. 2024

Plants

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“…Plant extracts and their bioactive compounds have been utilized for the treatment of several diseases since ancient times [ 5 ]. Medicinal plants were the major sources of bioactive compounds that could be used as potential alternatives to conventional antimicrobials [ 6 ]. The antibacterial activity of the plants could be ensured either by inhibiting the growth of bacteria or by disturbing the cell-to-cell communication system between the bacteria through anti-quorum sensing (AQS) [ 7 ], in which the latter is currently preferable, especially against antimicrobial-resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

Ethnomedicine, antibacterial activity, antioxidant potential and phytochemical screening of selected medicinal plants in Dibatie district, Metekel zone, western Ethiopia

Anbessa,

Lulekal,

Hymete

et al. 2024

BMC Complement Med Ther

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Background Medicinal plants play a major role in the delivery of healthcare, particularly among the rural population of Ethiopia. Plant extracts and their bioactive compounds have been utilized for the treatment of several diseases. This study was aimed at evaluating the antibacterial activity, antioxidant capacity, and phytochemical content of selected medicinal plants used in Dibatie district, western Ethiopia. Methods Study plants were collected, shade dried, pulverized, extracted by maceration in 80% ethanol, and subjected to antibacterial, antioxidant, and phytochemical tests. Minimum inhibitory concentration (MIC) was determined using 96-well microplates and nutrient broth microdilution. Antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Phytochemical screening was conducted using standard test methods. Results The ethanolic extract of Polystachya steudneri Rchb.f. pseudobulbs was the most active against gram-negative Proteus mirabilis, Salmonella typhimurium, Klebsiella pneumoniae, Escherichia coli, and Shigella flexneri, with MIC values of 8 ± 0, 11 ± 5, 3 ± 1, 3 ± 1, and 2 ± 0 mg/mL, respectively. The ethanolic extract of P. steudneri was also the most effective against gram-positive Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, and Enterococcus faecalis, with MIC values of 8 ± 0, 8 ± 0, 3 ± 1, and 16 ± 0 mg/mL, respectively. Ethanolic extracts of Gnidia involucrata Steud. ex A.Rich. stems and roots were effective antioxidants, with respective 50% DPPH free radical inhibitory concentrations (IC50) of 168.68 and 181.79 µg/mL, followed by that of P. steudneri (IC50 = 203.11 µg/mL). The study plants contained alkaloids, anthocyanins, anthraquinones, cardiac glycosides, coumarins, flavonoids, phenols, saponins, steroids, tannins, and terpenoids. Conclusions This study confirmed the antibiotic, antioxidant, and phytochemical constituents of the investigated plants and suggested further investigations that may lead to bioactive lead compounds.

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“…One of the most frequent symptoms related to these is microbial proliferation due to the presence of sweating pores, high humidity and certain darkness in this body area due to the coverage promoted through the hairs. Medicinal plants are a treatment bias for these diseases because they contain bioactive compounds with antimicrobial and antifungal action, representing an alternative to conventional drugs that exhibit a high rate of resistance due to their indiscriminate use by the population (Rajput & Kumar, 2020;Domingues, et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Extracts and Fractions with antifungal potential for the treatment of hair disorders

Medeiros

Costa²,

Oliveira³

et al. 2022

RSD

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Medicinal plants are used with several therapeutic applications, with hair disorders. Among the symptoms caused by these diseases, it is pertinent to emphasize the psychic damages such as loss of self-esteem and physical symptoms such as itching and burning. The present study aims to highlight the beneficial effect of medicinal plants against the symptoms caused by hair disorders. This is an integrative literature review using the Pubmed, Science direct and Google Scholar platforms and as descriptors “phytochemical”, “animal”, “seborrheic dermatitis”, “plant”, “anti-inflammatory extracts”, “antifungal” in English, crossed using the Boolean operators “AND” or “OR”. The selection of works took place after reading the title and abstract, with publication date between the years 2012-2022, excluding review studies, duplicate articles and thematic leakage. After extracting the data, 23 studies were selected that proved the effectiveness of plants on hair disorders, performing antifungal action (especially on fungi of the Malassezia spp. and Trichophyton spp.) and antioxidant due to the presence of phytochemical components such as flavonoids, phenolics, tannins, terpenoids, among others. It is noteworthy that most of these plants are processed using the maceration technique to obtain their extracts. Therefore, the bioactive compounds of these plants can be used for the development of pharmaceutical products with the purpose of expanding the therapeutic options on the market and optimizing the quality of life of patients, making it essential to encourage scientific research that discusses safety, efficacy and toxicity from the use of these metabolites.

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Medicinal plants: A potential source of novel bioactive compounds showing antimicrobial efficacy against pathogens infecting hair and scalp

Cited by 17 publications

References 64 publications

Corchorus tridens L.: A Review of Its Botany, Phytochemistry, Nutritional Content and Pharmacological Properties

Corchorus tridens L.: A Review of Its Botany, Phytochemistry, Nutritional Content and Pharmacological Properties

Ethnomedicine, antibacterial activity, antioxidant potential and phytochemical screening of selected medicinal plants in Dibatie district, Metekel zone, western Ethiopia

Extracts and Fractions with antifungal potential for the treatment of hair disorders

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