Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Kirichenko, Tatiana V.; Sukhorukov, Vasily N.; Markin, Alexander M.; Nikiforov, Nikita G.; Liu, Ping Yen; Sobenin, Igor A.; Tarasov, Vadim V.; Orekhov, Alexander N.; Aliev, Gjumrakch

doi:10.3389/fphar.2020.00403

Cited by 46 publications

(35 citation statements)

References 136 publications

(197 reference statements)

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“…It is known that one of the surrogate markers and an indicator of early atherosclerosis, widely used in epidemiological and interventional studies, is the carotid intima-media thickness (cIMT) measured in common carotid arteries by high-resolution ultrasonography (Baldassarre et al, 2010;Kirichenko et al, 2020b). On the other hand, there is increasing evidence showing the association of TMAO with an increased risk of cardiovascular disease development (Senthong et al, 2016a;Haghikia et al, 2018).…”

Section: The Association Of Human Microbiome With Atherosclerosis Andmentioning

confidence: 99%

A Novel Insight at Atherogenesis: The Role of Microbiome

Kirichenko

Markina

Sukhorukov

et al. 2020

Front. Cell Dev. Biol.

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There is an important task of current medicine to identify mechanisms and new markers of subclinical atherosclerosis in order to develop early targets for the diagnosis and treatment of this disease, since it causes such widespread diseases as myocardial infarction, stroke, sudden death, and other common reasons of disability and mortality in developed countries. In recent years, studies of the human microbiome in different fields of medicine have become increasingly popular; there is evidence from numerous studies of the significant contribution of microbiome in different steps of atherogenesis. This review attempted to determine the current status of the databases PubMed and Scopus (until May, 2020) to highlight current ideas on the potential role of microbiome and its metabolites in atherosclerosis development, its mechanisms of action in lipids metabolism, endothelial dysfunction, inflammatory pathways, and mitochondrial dysfunction. Results of clinical studies elucidating the relationship of microbiome with subclinical atherosclerosis and cardiovascular disease considered in this article demonstrate strong association of microbiome composition and its metabolites with atherosclerosis and cardiovascular disease. Data on microbiome impact in atherogenesis open a wide perspective to develop new diagnostic and therapeutic approaches, but further comprehensive studies are necessary.

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Section: The Association Of Human Microbiome With Atherosclerosis Andmentioning

confidence: 99%

A Novel Insight at Atherogenesis: The Role of Microbiome

Kirichenko

Markina

Sukhorukov

et al. 2020

Front. Cell Dev. Biol.

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“…Therefore, timely prevention and therapy of atherosclerosis is highly essential to reduce the risk of the development of its clinical manifestations. [7] These risk factors collectively contribute to the development, progression, and rupture of atherosclerotic plaque. [8] Natural plant products can be used for the treatment or prevention of cardiovascular and metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…[8] Natural plant products can be used for the treatment or prevention of cardiovascular and metabolic disorders. [9] These plant-derived antioxidants [7,10] can play an essential role in the prevention of cardiovascular diseases [11][12][13] mainly atherosclerosis. [14] Due to its strong free radical scavenging activity, rejuvenation of health is possible if used in dietary supplements.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Upadhyay¹

2021

IJGP

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The present review article explains antihyperlipidemic and cardioprotective effects of various plant natural products. These are antioxidants which found in vegetable oils, fruits, seeds, plant leaves, stem, and plant roots. This article emphasizes therapeutic potential of sulfur-containing compounds, anthraquinones, thiosulfinates and ajoenes, tricin, quercetin, Kaikasaponin III and tectorigenin, polyphenols, vitamins and minerals, flavonoid, and phenolics mainly naringenin; aglycone, flavanone (+)-catechin, (−)-epicatechin, and procyanidin B2, quercetin, kaempferol, myricetin, rutin, naringenin, catechin, fisetin, and gossypetin, thymol and carvacrol, ceramicine B (limonoid), ginsenoside Rb1 and Rb2, naphthalenic compounds 6-methoxysorigenin and its glycosides, acylates, madecassoside (terpenoids), Miroestrol (phytoestrogen), quercetin rutinoside (rutin), tournefolal, and tournefolic acids A and B. Few other compounds such as thiobarbituric acid, niacin, hederagenin monodesmosides, kalopanaxsaponin A (KPS-A) and sapindoside C, abietane and seco-abietane diterpenes, lycopene, Curcurbitacins A, B, C, D, E, I, J, K, and L, and Colocynthosides A and B were found active. For a healthy life regular intake of plant natural products or herbal diets significantly reduce the cardiovascular risks. Before use, well-designed clinical trials are essentially required to explore real efficacy and safety of these plant products. For management of cardiovascular risks lipid profile is highly needful at an earlier stage. In addition, microlevel biomolecular changes responsible for multiple morbidities affiliated to CVD diseases must be measured to find minor changes at an earlier stage.

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“…Medicinal plants are predominant ingredients of healthy diets and especially of Mediterranean diet. A current review carried out by Kirichenko et al (2020) thoroughly described the medicinal plants which have exerted anti-atherosclerotic activity in experimental and clinical studies 5 . This activity is mainly attributed to their content of bioactive compounds with pleiotropic effects such as antioxidant and anti-inflammatory properties, acting with different mechanisms of actions 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Mountain tea (Sideritis plants): A potential anti-atherogenic agent?

Tomou¹,

Perrea²,

Skaltsa³

2021

JAPT

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Atherosclerosis consists the leading cause of cardiovascular diseases. Over the last years, medicinal plants are considered as efficient agents in the prevention and adjuvant therapy of atherosclerosis. Mountain tea (Sideritis plants) is used as traditional remedy against common cold and gastrointestinal disorders. Its beneficial properties are attributed to its rich bioactive constituents. Polyphenols exhibit a broad range of pharmacological activities such as antioxidant, anti-inflammatory and anti-atherosclerotic effects. The present review summarizes and discusses the potential of mountain tea as an anti-atherogenic agent based on its bioactive chemical compounds and their reported pharmacological activities.

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Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Cited by 46 publications

References 136 publications

A Novel Insight at Atherogenesis: The Role of Microbiome

A Novel Insight at Atherogenesis: The Role of Microbiome

Untitled

Mountain tea (Sideritis plants): A potential anti-atherogenic agent?

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