Medicinal plants used by traditional medicine practitioners in the treatment of tuberculosis and related ailments in Uganda

Tabuti, John R. S.; Kukunda, Collins B.; Waako, Paul

doi:10.1016/j.jep.2009.09.035

Cited by 149 publications

(121 citation statements)

References 15 publications

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“…This is believed to be true especially in the context of developing countries where there is little or no access to modern health services (Mann et al, 2007;Idu et al, 2010). The current study builds upon previous efforts in prospecting for antituberculosis activities among some traditional plants used in Eastern and Southern Africa (Tabuti et al, 2009;Earl et al, 2010;Mariita et al, 2010a). However, an important addition is that prior to conducting bioassays the main practitioners also known as herbalists were interrogated from whom identities of plants which have been used to manage "persistent coughs" was established.…”

Section: Introductionmentioning

confidence: 99%

Potency of extracts of selected plant species from Mbeere, Embu County-Kenya against Mycobacterium tuberculosis

Njeru¹,

Obonyo²

2016

J. Med. Plants Res.

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Tuberculosis is a serious chronic infectious disease affecting large global population. While efforts to control tuberculosis have intensified, they are challenged by rapid drug resistance development. For this reason, prospecting for compounds with potential antituberculous activity have been stepped up. The current study was done in a participatory appraisal manner to identify ten plants commonly used for management of "persistent coughs". Bioassays were conducted against Mycobacterium tuberculosis (H37Rv ATCC 27294) using the BACTEC MGIT ™ 960 system. This was followed by assay of toxicity of the extracts towards Vero cells (ATCC CCL-81). Six extracts showed remarkable antitubercular activity. Four extracts had complete inhibition (0 GU-Growth Units) of Mycobacterium tuberculosis. The extracts were tested for their general antimicrobial activity and found to be broad spectrum antimicrobials. The highest activity against Escherichia coli (15.3 mm) was by Cissampelos pareira, while Mangifera indica yielded the highest activity against Staphylococcus aureus (11.7 mm) and Candida albicans (12.0 mm). In addition, six crude methanolic extracts were found to be within the acceptable toxicity limit (CC 50 <90 µg/ml). The observed activity is attributable to phytochemicals in the extracts, including: phenols, terpenoids, flavonoids and anthraquinones. These findings could partly explain observed "positive" treatment outcome by indigenous people using these plant formulations.

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Section: Introductionmentioning

confidence: 99%

Potency of extracts of selected plant species from Mbeere, Embu County-Kenya against Mycobacterium tuberculosis

Njeru¹,

Obonyo²

2016

J. Med. Plants Res.

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“…This provided some redundancy and therefore increases safety of supply (Walker, 1992). Against tuberculosis, only one medicinal plant species was found during the transect walks (Carissa edulis) (Tabuti et al, 2010). This species can also be used to treat e.g.…”

Section: Diversity Of Medicinal Plantsmentioning

confidence: 99%

Diversity of Medicinal Plants and Anthropogenic Threats in the Samburu Central Sub-County of Kenya

Gafna¹,

Dološ²,

Mahiri³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Traditional herbal medicine has been a constant source of substances for curing and preventing a variety of ailments. Biodiversity of medicinal plants and effects of human activities on availability of traditional herbal medicine have continuously received just a cursory treatment. This study sought to determine the biodiversity of medicinal plants and evaluate the effects of human activities on availability of traditional herbal medicine among the Samburu pastoral community in Kenya. Materials and Methods: A questionnaire survey was addressed to 195 randomly stratified household respondents in four villages in Samburu Central Sub-county. Transect walks were carried out in the four villages to determine the diversity of the medicinal plants. Voucher specimens of the medicinal plant species were deposited at Kenyatta University Herbarium. Results: The species richness comprised of 19 medicinal plants, majority of which grew in the wild but were threatened by human activities. 56% of the households reported that fire incidences highly affected availability of traditional herbal medicine, 50% reported that grazing of livestock moderately affected availability of traditional herbal medicine, 46% reported that building and construction activities moderately affected availability, while 43% and 40% reported that firewood collection and growing of crops respectively lowly affected availability of traditional herbal medicine among the Samburu people. Conclusion: Most of the Samburu people use traditional herbal medicine. However, majority of the medicinal plants are threatened by anthropogenic factors. This has led to the continued decline of traditional herbal medicine. There is, therefore need to adopt management strategies that enhance the conservation of these valuable natural resources.

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“…3-α-tigloyl-melianol has no toxicity on Vero cells which is very important for further research [16]. [5][6][7][8] South America is another huge area where folk medicine is the main treatment. Allophylus edulis is an endemic plant of the region which is commonly known as a good anti-inflammatory remedy.…”

Section: Extracts and Natural Substances Isolated From Plantsmentioning

confidence: 99%

“…It is an interesting fact that traditional medicinal practitioners sometimes add honey, Zingiber officinale or rock salt. Generally, they make decoctions from these parts of plants and the dosage is 1-2 teaspoons or tablespoons [5]. A similar situation exists in Laos, where healers use 77 various plants, of which only 10% display any anti-mycobacterial activity.…”

Section: Introductionmentioning

confidence: 98%

Anti-tubercular substances produced by plants

Polak¹,

Kapka‐Skrzypczak²

2017

J Pre Clin Clin Res.

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Tuberculosis is one of the common causes of death worldwide, and according to the World Health Organization, in 2015, about 10.4 mln people globally is suffering from that disease. Despite great development in medicine and discovery of many antimycobacterial drugs, tuberculosis remains an unsolved problem. The populations of countries in Africa, Asia and South America have difficult access to hygiene, medical care and medicines, and they therefore resort to consulting traditional practitioners who mainly use drugs from natural sources which they prepare themselves. Plants are the biggest source of such medicines and are used as extracts, decoctions or powders, often without any evidence of their actual activity. Isolates from plants sometimes contain unknown substances or some second metabolites of microorganisms. In vitro studies have shown that some of these medicines have effective antimycobacterial properties, even against clinical, resistant strains. This is hopeful in the situation where more and more cases of tuberculosis prove to be resistant to standard drugs. Extracts of medicinal plants are often synergistic with synthetic drugs. Substances with insufficient MIC can be a basis for derivatives which have better properties. This thesis summarizes the current international knowledge of the use of plant substances used in the treatment of tuberculosis that could be potential new antituberculous drugs.

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Medicinal plants used by traditional medicine practitioners in the treatment of tuberculosis and related ailments in Uganda

Cited by 149 publications

References 15 publications

Potency of extracts of selected plant species from Mbeere, Embu County-Kenya against Mycobacterium tuberculosis

Potency of extracts of selected plant species from Mbeere, Embu County-Kenya against Mycobacterium tuberculosis

Diversity of Medicinal Plants and Anthropogenic Threats in the Samburu Central Sub-County of Kenya

Anti-tubercular substances produced by plants

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