Medicinal Plants Used in the Management of Noncommunicable Diseases in Uganda

Kakudidi, Esezah; Kirimuhuzya, Claude; Anywar, Godwin; Katuura, Esther; Kiguli, Juliet

doi:10.1007/978-981-10-1085-9_17

Cited by 9 publications

(13 citation statements)

References 45 publications

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“…Management of anaemia [39], dysentery, coughs, chest pains, tuberculosis, stomach complaints, food poisoning, purgative and emetic, roundworm infections and other intestinal parasites. Used as an emollient, stimulant, diuretic and in treatment of skin infections, eczema, leprosy, ulcers, diabetes mellitus, colic, stomach pains, pains after childbirth, gale, inappetence, fever, constipation, malaria, sexually transmitted infection, and rheumatism [33,192,193] Antioxidant, analgesic, antibacterial, anti-inflammatory, and antidiabetic activities [194,195] Carica papaya L.…”

Section: Growth Habit Parts Used Preparation and Mode Ofmentioning

confidence: 99%

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Omara

Kiprop

Ramkat

et al. 2020

Evidence-Based Complementary and Alternative Medicine

109

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The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of plants with reported anticancer activity used in rural Uganda and the evidences supporting their use in cancer therapy. An electronic survey in multidisciplinary databases revealed that 29 plant species belonging to 28 genera distributed among 24 families have been reported to be used in the management of cancer in Uganda. Anticancer plants were majorly from the families Bignoniaceae (7%), Caricaceae (7%), Fabaceae (7%), Moraceae (7%), and Rutaceae (7%). Most species occur in the wild (52%), though some are cultivated (48%). The growth habit of the plants is as trees (55%) or herbs (45%). Anticancer extracts are usually prepared from leaves (29%), bark (24%), roots (21%), and fruits (13%) through decoctions (53%), as food spices (23%) or pounded to produce ointments that are applied topically (10%). Prunus africana (Hook.f.) Kalkman, Opuntia species, Albizia coriaria (Welw. ex Oliver), Daucus carota L., Cyperus alatus (Nees) F. Muell., Markhamia lutea (Benth.) K. Schum., and Oxalis corniculata L. were the most frequently encountered species. As per global reports, Allium sativum L., Annona muricata L., Carica papaya L., Moringa oleifera Lam., Opuntia species, Prunus africana (Hook.f.) Kalkman, and Catharanthus roseus (L.) G. Don. are the most studied species, with the latter having vincristine and vinblastine anticancer drugs developed from it. Prostate, cervical, breast, and skin cancers are the top traditionally treated malignancies. There is a need to isolate and evaluate the anticancer potential of the bioactive compounds in the unstudied claimed plants, such as Cyperus alatus (Nees) F. Muell., Ficus dawei Hutch., Ficus natalensis Hochst., and Lovoa trichilioides Harms, and elucidate their mechanism of anticancer activity.

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Section: Growth Habit Parts Used Preparation and Mode Ofmentioning

confidence: 99%

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Omara

Kiprop

Ramkat

et al. 2020

Evidence-Based Complementary and Alternative Medicine

109

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“…Uganda has a rich plant diversity with about 5406 native vascular plant species so far known to exist (Davis et al 1994). Relatedly, there is rich diversity of traditional medical practices as well as medicinal plants across the country as evidenced from previous studies (Asiimwe et al 2021;Kakudidi et al 2016;Lamorde et al 2010;Namukobe et al 2011;Tabuti et al 2010;Tugume et al 2016). As such, in order to get a clear picture of plant species used in the management of DM in Uganda, one has to atleast consider the different ethnic groups or agroecological zones.…”

Section: Introductionmentioning

confidence: 92%

Ethnobotanical survey of medicinal plants used for the treatment of diabetes in Uganda

Uwimbabazi,

Kabinesa,

Ongarep

et al. 2023

Ethnobot. Res. App.

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Background: Type 2 Diabetes Mellitus (DM) is increasingly becoming a global health problem. In Uganda, DM prevalence rate has more than doubled in the last decade. Although management options for DM are various including conventional medicine, physical exercise and diet, use of traditional medicine has increasingly gained traction. However, there is little information about the medicinal plants used for managing DM in Uganda and it is against this background that this study was conducted.Methods: An ethnobotanical survey was conducted in the four regions of Uganda represented by 24 districts. Information was collected from 197 traditional medical practitioners (TMPs) who were selected using purposive and snowball sampling techniques and interviewed using semi-structured questionnaires. Data was presented using descriptive statistics and quantitatively analysed using the use value (UV) and ANOVA and principal component analysis.Results: A total 71 medicinal plant species belonging to 44 families were mentioned by the TMPs as being used in the management of DM. The Fabaceae and Moraceae accounted for the highest number of plant species. Although woody and wildly occurring plants accounted for the highest number of plants listed in the management of diabetes, the most frequently used plants were herbaceous and domesticated plant species. An indication that TMPs frequently use plants that are available and easy to access. There was high similarity in the plant species mentioned by TMPs in the Eastern-Northern regions and those in the Central-Western regions and this is perhaps due to the similarities in climatic and ethnic factors experienced by these regions. Conclusion:This study contributes to the wealth of knowledge on medicinal plants used to manage DM in the world. It underscores the significance of plant species towards human health and ultimately the need to conserve them. Further research should be carried out to validate the antidiabetic potential of the mentioned medicinal plant species in this study.

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“…Benth. which is recorded to be used for treating various health problems such as diarrhea, malaria, and cancer across different communities [19]. As such, pharmacological efficacy of K. africana against cancer has also been reported, for instance, its seed oil suppressed human embryonic kidney (HEK-293) cell and human colon adenocarcinoma (Caco-2) cell dose dependently [297].…”

Section: Other Ethnomedicinal Uses and Toxicity Of The Reported Antid...mentioning

confidence: 99%

“…Ethnopharmacological studies are, by definition, scientific approaches to the study of biological activities of preparations used by humans, which possess, either beneficial or toxic or other direct pharmacological effects [15] and thus, ethnopharmacology involves investigating the relationship between humans and plants in all its complexity [15]. Accordingly, several ethnobotanical surveys conducted in Uganda have revealed that various medicinal plants are used in the management of DM [16][17][18][19][20][21][22][23][24]. Indeed, ethnopharmacological studies have reported the anti-diabetic efficacy of some of these plants and their derived formulations [23,25].…”

Section: Introductionmentioning

confidence: 99%

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

et al. 2023

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Diabetes mellitus (DM) is a global health problem owing to its high prevalence and increased morbidity and mortality. The prevalence of DM and impaired glucose tolerance in Uganda is approximately 4.1% and 6.6%, respectively. Medicinal plants are commonly used for the management of DM, especially in developing countries, such as Uganda. According to several ethnobotanical surveys conducted in Uganda, various medicinal plants are used in DM management. Meanwhile, ethnopharmacological studies have confirmed the anti-diabetic efficacy of various plants and plant-derived formulations from Uganda. However, these information remain highly fragmented without a single repository for plants used in the management and treatment of DM in Uganda, hindering further investigations. Therefore, this study aimed to comprehensively explore plants used for DM treatment in Uganda and retrieve relevant ethnopharmacological and ethnomedicinal information that can be used for DM therapy development. English peer-reviewed articles and books were searched in scientific databases, especially PubMed, Scopus, Google Scholar, Science Direct, SciFinder, and Medline, to retrieve information on medicinal plants used for DM treatment and management in Uganda. The databases were searched to obtain published literature on the anti-diabetic activities and safety of plants among the identified plants. The family name, plant parts used, anti-diabetic activities, dosage, and mechanisms of action of plant extracts were captured. In total, 46 species belonging to 26 families are used to treat DM in Uganda. Most species belonged to the Fabaceae (20%), Asteraceae (13%), and Solanaceae (7%) families. Anti-diabetic activities of 27 (59%) species have been scientifically investigated, whereas the rest have not been evaluated. This review indicated that various medicinal plants are used in the traditional treatment and management of DM across different regions in Uganda. Scientific investigations have revealed the anti-diabetic potential and safety of several of these plants. However, there is a need to validate the anti-diabetic potential of other unstudied plants. Additionally, isolating and characterizing active principles and elucidating the anti-diabetic mechanism of these plants and performing preclinical and clinical studies in the future could aid in the formulation of an effective and safe treatment for DM.

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Medicinal Plants Used in the Management of Noncommunicable Diseases in Uganda

Cited by 9 publications

References 45 publications

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Ethnobotanical survey of medicinal plants used for the treatment of diabetes in Uganda

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

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