Medicinal plants with hypoglycemic activity

Atta-ur-Rahman, _; Zaman, Khurshid

doi:10.1016/0378-8741(89)90112-8

Cited by 209 publications

(65 citation statements)

References 59 publications

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“…The blood sugar lowering effect of U. dioica as a medicinal herb has been introduced in old script such as those written by Avicenna (Farzami et al, 2003). In addition, U. dioica is among several species listed for their use against diabetes in folk medicine in a large pharmacological screen of European species (Atta-Ur- Rahman & Zaman, 1989).…”

Section: Introductionmentioning

confidence: 99%

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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GOLALIPOUR, M. J.; GHAFARI, S.; LATIFIMOGHADAM, M. H. & KABOLI, S.Alteration of dentate gyrus astrocytes in diabetic rats: Protective role of Urtica dioica. Int. J. Morphol., 29(4):1307-1312, 2011. SUMMARY:Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days intraperitoneally. Four weeks after induction of diabetes, animals were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH stain. The area densities of the astrocytes were measured and compared in the three groups (p < 0.05). The number of astrocytes in DG area of controls was 17.72±6.7. The density of astrocytes increased in diabetic (24.26±9.5) in comparison with controls. The density in the nettle treated rats (23.17±5.8) was lower than diabetic rats. This study showed that the administration of U. dioica extract before induction of diabetes can not significantly help compensate for astrocytes in the dentate gyrus of treated rats.

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Section: Introductionmentioning

confidence: 99%

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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“…Approximately 343 plants of the world have been tested for the blood glucose which found lowering effect in the laboratory experiments. Of them, 158 species are claimed to be used in traditional system on Indian medicine [8].…”

Section: Introductionmentioning

confidence: 99%

Review Article: Herbal Approach for Obesity Management

Chandrasekaran¹,

Vijayalakshmi²,

Prakash³

et al. 2012

AJPS

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Obesity, a complex interplay between environmental and genetic factors and is associated with significant morbidity and mortality. Usage of herbs for the management of obesity in the recent times is attracting attention. A web and manual based literature survey was conducted to assess the amount of information available on the herbal products for weight management. Traditional literature, PubMed, Scopus, Google scholar databases were screened up to February 2012. The search words were "obesity", "herbal medicine/products/extracts", "medicinal plants", "traditional medicine", "Ayurvedic medicine" without narrowing/limiting searching words or elements. Publications only with abstracts/full articles and books were reviewed in the search. Based on the available literature, for many of the herbal and weight loss products, there is little published information and there have been no clinical trials or the level of evidence is limited. Our literature survey also indicated that these herbal products fall under an acceptable level of evidence or with no scientific background at all, or they have a scientific rational but not to an acceptance level. Attempts were made in the review to define the features of possible herbal weight loss product. An ideal herbal anti obesity product should reduce the weight by 10% over placebo of treatment by showing an evidence of improvement of bio markers like blood pressure, lipids and glycemia without any side effects.

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“…Numerous herbal preparations have been shown to affect blood glucose levels through various mechanisms, although they are usually limited by toxicity, relative lack of efficacy and standardization of ingredients medications [11] [13] [14] [15]. One of the common medicinal plants is Momordica charnatia, which has been used in various traditional medicines [16].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Study on the Effects of <i>Momordica charantia</i> on Streptozotocin-Induced Diabetic Wistar Rats

Moqbel¹,

Al-Hizab²,

Barakat³

2017

OJVM

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Momordica charantia (MC) a traditional medicine used for the treatment of many disorders was fed to streptozotocin (STZ)-induced diabetic male Wistar rats at 2, 5 and 10% of the standard diet. Rats were then observed for 12 weeks before sacrificed. Immediately, tissues from liver, kidney and pancreas were taken for histopathological examination. Serum samples were analyzed to evaluate liver, kidney and pancreatic functions. In addition, blood samples were collected to analyze hematology parameters. The results of the present study indicate that oral doses of MC at 5% and 10% of the daily diet resulted in alleviation of the pancreatic, hepatic and renal dysfunction induced by diabetes. The improved pancreatic, hepatic and renal functions were judged by histopathological, hematological and serobiochemical parameters. In conclusion, the MC fruits may be used as an antidiabetic herbal medicine.

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Medicinal plants with hypoglycemic activity

Cited by 209 publications

References 59 publications

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Review Article: Herbal Approach for Obesity Management

Clinicopathological Study on the Effects of <i>Momordica charantia</i> on Streptozotocin-Induced Diabetic Wistar Rats

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Medicinal plants with hypoglycemic activity

Cited by 209 publications

References 59 publications

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

Review Article: Herbal Approach for Obesity Management

Clinicopathological Study on the Effects of &lt;i&gt;Momordica charantia&lt;/i&gt; on Streptozotocin-Induced Diabetic Wistar Rats

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Clinicopathological Study on the Effects of <i>Momordica charantia</i> on Streptozotocin-Induced Diabetic Wistar Rats