Medicinal preparations on the basis of vegetable phenolic compounds

Kemertelidze, E. P.; Alania, M; Sagareishvili, T. G.; Shalashvili, K. G.; Kavtaradze, N. Sh.

doi:10.1055/s-0029-1234541

Cited by 3 publications

(3 citation statements)

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“…-species of Astragalus genus, is broadly available in Georgia. This plant has been thoroughly studied at the I. Kutateladze Institute of Pharmacochemistry (IKIP), Tbilisi State Medical University (TSMU) [26][27]. The hypoazotemic flavonoid glycoside was separated from above ground parts of Astragalus falcatus Lam and Flaroninum™ -an original remedy for the treatment of CRF complicated by azotemia, has been developed on its basis in the tablets form (30 mg) [28].…”

Section: Introductionmentioning

confidence: 99%

Interactions of Bioflavonoid Robinin With Efflux Transporters: P-Glycoprotein and Breast Cancer Resistance Protein

Tsiklauri

Alania

et al. 2023

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Present study investigated the possible role of P-glycoprotein in the intracellular exposure of active substance (robinin) of natural medicine Flaroninum™ and effect of robinin on the cellular accumulation of mitoxantrone in either BCRP-overexpressing and BCRP-negative cells.Robinin -kaempferol-3-O--D-robinoside-7-O-α-L-rhamnopyranoside, has been obtained from over ground parts of Astragalus falcatus Lam., growing in Georgia. The compound possesses hypoazotemic and diuretic activities and is proposed for the complex therapy of kidney diseases. Pgp-overexpressing and P-gp-negative human breast cancer cells (MCF7) were used to examine the absorption character of kaempferol and robinin with or without of verapamil (P-gp inhibitor).Flavonoids concentrations were determined by LC/MS/MS. Robinin transport was P-gp-dependent and verapamil significantly increased the extent of uptake of robinin in cells, which is attributed in part to P-gp-inhibition by verapamil. When comparing the intracellular accumulation of aglycone with kaempferol-3-O--D-robinoside-7-O-α-L-rhamnopyranoside, we found that kaempferol uptake was greater than robinin. Since some glycosylated forms of flavonoids have been demonstrated to significantly suppress breast cancer resistance protein (BCRP/ABCG2), we hypothesized that kaempferol-3-O--D-robinoside-7-O-α-L-rhamnopyranoside may act as a BCRP-inhibitor. Mitoxantrone accumulation studies were performed in BCRP-overexpressing and BCRP-negative MCF7 cells using flow cytometric analysis. Robinin (5 and 50 M) had no significant impacts on the BCRP-mediated mitoxantrone transport; on the contrary, the aglycone kaempferol produced increased accumulation of mitoxantrone. From these results, we suggest that the active component of natural hypoazotemic medicine Flaroninum™, robinin, may be a substrate of P-gp and its efflux outside of the cells mediated P-gp may contribute to its decreased intracellular concentration.

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Section: Introductionmentioning

confidence: 99%

Interactions of Bioflavonoid Robinin With Efflux Transporters: P-Glycoprotein and Breast Cancer Resistance Protein

Tsiklauri

Alania

et al. 2023

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“…This plant has been intensively investigated at the I Kutateladze Pharmacochemistry Institute (IKPI) of the Tbilisi State Medical University (TSMU) and hypoazotemic flavonoid glycoside robinin was isolated from its aeria parts [13,14]. Based on this compound, the original preparation Flaroninum™ (FL) in the form of tablets has been proposed [14]. FL has been approved as a drug by the Georgian and Russian healthcare authorities.…”

Section: Introductionmentioning

confidence: 99%

Bioflavonoid Robinin from Astragalus falcatus Lam. Mildly Improves the Effect of Metothrexate in Rats with Adjuvant Arthritis

et al. 2021

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Anti-inflammatory potential of orally administrated bioflavonoid-robinin, active sub-stance of original drug Flaroninum™ (FL), was investigated in the combination with methotrexate (MTX) and in monotherapy in rats suffering from adjuvant-induced arthritis (AA). Robinin (kaempferol-3-O-robinoside-7-O-rhamnoside) was isolated from the aerial parts of Astragalus falcatus Lam. The monotherapy with robinin was not efficient in alleviating symptoms of AA. The combination of MTX with robinin was similarly active as MTX alone in reducing the hind paw volume and change of body weight during the whole experiment. The combination, however, reduced plasma levels of Interleukin-17Aand activity of gamma-glutamyl transferase in joint more efficiently then MTX alone. Our results demonstrate that the novel combination of robinin and MTX mildly improved the reduction of inflammation in experimental arthritis.

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“…This plant is used as a traditional medicinal herb in Europe, and the medicinal plant raw material of savory is the aerial part of the plant— Herba Satureae [ 8 , 9 ]. This plant contains two main groups of biologically active compounds, namely phenolic compounds and essential oils [ 10 , 11 , 12 , 13 , 14 ]. Phenolic compounds exert multiple biological effects such as antioxidant, free radical scavenging and anti-inflammatory properties [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts

Bimbiraitė-Survilienė

Stankevičius

Šuštauskaitė

et al. 2021

Antioxidants

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Satureja hortensis L. is an annual herbaceous plant of the Lamiaceae Lindl. family. S. hortensis L., related to thyme and rosemary, is used as spice and traditional medicinal herb in Europe. Mainly due to the polyphenols contained in S. hortensis L., this plant exhibits multiple biological effects. However, therapeutic effects on cells, including skin tumors, have not yet been studied. Therefore, the aim of this study was to compare the composition and the resulting antioxidant as well as biological properties [on melanocytes and melanoma cells] of summer, savory growing in botanical garden of Vytautas Magnus University in middle Lithuania climatic conditions, collected during various phases of vegetation. It has been shown that the budding phase alcohol extract of this plant contains the largest amounts of polyphenols, including rutin and rosemary acid, which promote the radical scavenging activity and antioxidant properties. In contrast, the extract from the massive flowering phase already at a concentration of 12.5 µg/mL reduces the survival of melanoma cells to 60% with 90% melanocytes survival. In addition, extracts from beginning of flowering and end of flowering at a concentration of 25 µg/mL, containing significantly less rutin and rosmarinic acid, in combination with irradiation of cells with UVB, significantly increased the lipid peroxidation process, particularly in melanoma cells. These data indicate the possibility of using extracts from S. hortensis L. to modulate/differentiate the metabolism of normal and tumor skin cells.

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Medicinal preparations on the basis of vegetable phenolic compounds

Cited by 3 publications

References 0 publications

Interactions of Bioflavonoid Robinin With Efflux Transporters: P-Glycoprotein and Breast Cancer Resistance Protein

Interactions of Bioflavonoid Robinin With Efflux Transporters: P-Glycoprotein and Breast Cancer Resistance Protein

Bioflavonoid Robinin from Astragalus falcatus Lam. Mildly Improves the Effect of Metothrexate in Rats with Adjuvant Arthritis

Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts

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