The complex study of fungi biota of the State Nature Reserve “Bylina” in Kirov region in 2010-2017 (apart from defining species composition of the territory) included the study of economically important species and also ones with potentially medicinal properties. Total number of macrofungi species of the area reached 377, including 84 edible, 6 – conditionally edible, 74 – non-edible, and 20 – poisonous species. The following species were subsumed to medicinal fungi: Lenzites betulinus, Stereum hirsutum, Fomes fomentarius, Fomitopsis pinicola, Russula foetens, Boletus edulis, Suillus granulatus, Amanita muscaria, Ramaria stricta, Coltricia perennis, Inonotus obliquus, Cantharellus cibarius, and also rarely found Pycnoporus cinnobarinus, Trametes suaveolens, Heterobasidion annosum, and Ramaria formosa. Keywords: KIROV REGION, MACROFUNGI, MACROMYCETES, EDIBLE MUSHROOMS, MEDICINAL FUNGI, BASIDIOMYCOTA, PROTECTED AREAS