Mediterranean X Western based diets: Opposite influences on opioid reinstatement

Milanesi, Laura Hautrive; Rossato, Domênika Rubert; Dias, Verônica Tironi; Kronbauer, Maikel; D’avila, Lívia Ferraz; Somacal, Sabrina; Duarte, Thiago; Duarte, Marta Maria Frescura Medeiros; Emanuelli, Tatiana; Bürger, Marilise Escobar

doi:10.1016/j.toxlet.2019.03.009

Cited by 17 publications

(6 citation statements)

References 81 publications

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“…Previous studies from our laboratory have shown CPP paradigm in experimental protocols related to AMPH addiction [14,29,30], besides other addictive substances such as cocaine [16] and morphine [31][32][33]. Thus, following drug extinction, events such as stress or drug re-exposure can reestablish the addiction, what may be experimentally observed by restoring the drug preference in the CPP paradigm [34].…”

Section: Discussionmentioning

confidence: 99%

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Rossato

Rosa

et al. 2022

Preprint

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Amphetamine (AMPH) is a psychostimulant drug frequently related to addiction, which is characterized by functional and molecular changes in the brain reward system, favoring relapse development and pharmacotherapies have shown low effectiveness. Considering the beneficial influences of tactile stimulation (TS) in different diseases that affect the central nervous system (CNS), here we evaluated if TS applied in adult rats could prevent or minimize the AMPH-relapse behavior also accessing molecular neuroadaptations in the Nucleus accumbens (NAc). Following AMPH conditioning in the conditioned place preference (CPP) paradigm, male rats were submitted to TS (15-min session, 3 times a day, for 8 days) during the drug abstinence period, which were re-exposed to the drug in the CPP paradigm for additional 3 days for relapse observation and molecular assessment. Our findings showed that besides AMPH relapse; TS prevented the dopamine transporter (DAT), dopamine 1 receptor (D1R), tyrosine hydroxylase (TH), mu opioid receptor (MOR) increase and AMPH-induced delta FosB (ΔFosB). Based on these outcomes, we propose TS as a useful tool to treat psychostimulant addiction, which subsequent to clinical studies; it could be included in detoxification programs together with pharmacotherapies and psychological treatments already conventionally established.

show abstract

Section: Discussionmentioning

confidence: 99%

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Rossato

Rosa

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previous studies from our laboratory have shown CPP paradigm in experimental protocol s related to AMPH addiction [ 14 , 33 , 34 ], besides other addictive substances such as cocaine [ 16 ] and morphine [ 35 – 37 ]. Thus, following drug extinction, events such as stress or drug re-exposure can reestablish the addiction, what may be experimentally observed by restoring the drug preference in the CPP paradigm [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse

Rossato

Rosa

et al. 2022

Mol Neurobiol

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Amphetamine (AMPH) is a psychostimulant drug frequently related to addiction, which is characterized by functional and molecular changes in the brain reward system, favoring relapse development, and pharmacotherapies have shown low effectiveness. Considering the beneficial influences of tactile stimulation (TS) in different diseases that affect the central nervous system (CNS), here we evaluated if TS applied in adult rats could prevent or minimize the AMPH-relapse behavior also accessing molecular neuroadaptations in the nucleus accumbens (NAc). Following AMPH conditioning in the conditioned place preference (CPP) paradigm, male rats were submitted to TS (15-min session, 3 times a day, for 8 days) during the drug abstinence period, which were re-exposed to the drug in the CPP paradigm for additional 3 days for relapse observation and molecular assessment. Our findings showed that besides AMPH relapse, TS prevented the dopamine transporter (DAT), dopamine 1 receptor (D1R), tyrosine hydroxylase (TH), mu opioid receptor (MOR) increase, and AMPH-induced delta FosB (ΔFosB). Based on these outcomes, we propose TS as a useful tool to treat psychostimulant addiction, which is subsequent to clinical studies; it could be included in detoxification programs together with pharmacotherapies and psychological treatments already conventionally established.

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“…However, it is a strong possibility given findings from two recent studies with fish oil. Specifically, these studies showed that chronic treatment with fish oil, which like sesame oil is rich in essential polyunsaturated fatty acids (Sowmya et al, 2009), prevented the reinstatement of an amphetamine or morphine-induced CPP and associated molecular changes (Metz et al, 2019; Milanesi et al, 2019). Sesame oil is also rich in linoleic acid, which has been reported to have antagonistic effects on ER signaling (Durgam and Fernandes, 1997; Kenny et al, 2000; Tanmahasamut et al, 2004; Liu and Sidell, 2005).…”

Section: Discussionmentioning

confidence: 99%

Tamoxifen Blocks the Development of Motivational Features of an Addiction-Like Phenotype in Female Rats

Bakhti-Suroosh

Nesil

Lynch

2019

Front. Behav. Neurosci.

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Women become addicted sooner after initiating cocaine use as compared to men. Preclinical studies reveal a similar vulnerability in females, with findings from ovariectomized rats suggesting that estradiol mediates the enhanced vulnerability. However, since ovariectomy depletes not only estradiol, but all ovarian hormones, its role in a physiological context is not clear. Thus, the goal of this study was to determine the role of estradiol in the development of an addiction-like phenotype in ovaryintact females treated chronically with the selective estrogen receptor (ER) modulator tamoxifen. We hypothesized that tamoxifen, by antagonizing ERs, would block the development of an addiction-like phenotype as defined by an enhanced motivation for cocaine (assessed under a progressive-ratio schedule), and a heightened vulnerability to relapse (assessed under an extinction/cue-induced reinstatement procedure). Effects were examined following extended access cocaine self-administration (24-h/day; 4discrete trials/h; 1.5 mg/kg/infusion) and 14-days of abstinence, conditions optimized for inducing an addiction-like phenotype. As predicted, motivation for cocaine was increased following extended-access self-administration and protracted abstinence in the vehicle (sesame oil) and no-injection control groups, but not in the tamoxifen group indicating that ER signaling is critical for the development of this feature of an addiction-like phenotype. Surprisingly, the increase in motivation for cocaine following abstinence was also attenuated in the vehicle group as compared to no-injection controls suggesting that oil/injections also affected its development. Contrary to our hypothesis, tamoxifen did not decrease vulnerability to relapse as this group responded at similar levels during initial extinction sessions and cue-induced reinstatement testing as compared to controls. Tamoxifen did, however, impair extinction learning as this group took longer to extinguish as compared to controls. Taken together, these findings indicate that estradiol is critical for the extinction of drug-associated cues and the development of motivational features of addiction.

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Mediterranean X Western based diets: Opposite influences on opioid reinstatement

Cited by 17 publications

References 81 publications

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus Accumbens Preventing Amphetamine Relapse.

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse

Tamoxifen Blocks the Development of Motivational Features of an Addiction-Like Phenotype in Female Rats

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