Medium and long-chain structured triacylglycerol enhances vitamin D bioavailability in an emulsion-based delivery system: combination of <i>in vitro</i> and <i>in vivo</i> studies

Guo, Yiwen; Xu, Ying; Zhang, Tao; Wang, Yandan; Liu, Ruijie; Chang, Ming; Wang, Xingguo

doi:10.1039/d1fo03407c

Cited by 14 publications

(12 citation statements)

References 55 publications

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“…These differences can further affect the ability to accommodate fat-soluble vitamins when forming micelles, that is, bioaccessibility. Previous work in our laboratory has demonstrated that STG was greater than PM in VitD bioaccessibility …”

Section: Introductionmentioning

confidence: 85%

“…STG and PM were prepared according to previous research. 19 The total ion chromatograms of TAG of PM and STG are shown in Figure 1a. The detailed information of FA and TAG composition is reported in a previous study.…”

Section: Methodsmentioning

confidence: 99%

“…The detailed information of FA and TAG composition is reported in a previous study. 19 2.2. Designs of Animal Experiments and Diets.…”

Section: Methodsmentioning

confidence: 99%

“…Previous work in our laboratory has demonstrated that STG was greater than PM in VitD bioaccessibility. 19 Herein, we innovatively hypothesize that other therapeutic effects on UC might be achieved if VitD was delivered to the body by different absorption and metabolic characteristics in vivo. In this sense, as an improvement and extension of our previous work, fabrications of two other different TAG structures but identical FA composition MLCT, structured triacylglycerol (STG) and physical mixtures of triacylglycerol (PM), were performed to prove our hypothesis.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Medium- and Long-Chain Structured Triacylglycerol on the Therapeutic Efficacy of Vitamin D on Ulcerative Colitis: A Consideration for Efficient Lipid Delivery Systems

Guo

Wang

et al. 2023

J. Agric. Food Chem.

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Due to intestinal malabsorption and poor water solubility, vitamin D (VitD) deficiency in ulcerative colitis (UC) continues to increase. Medium- and long-chain triacylglycerols (MLCT), as novel lipids, have been widely applied in the field of functional food and medicine nutrition. Our previous studies showed that the difference in MLCT structure could affect VitD bioaccessibility in vitro. In this study, our results further indicate that, although identical in fatty acid composition, structured triacylglycerol (STG) had a higher VitD bioavailability (AUC = 15470.81 μg/L × h) and metabolism efficacy [s-25(OH)D, p < 0.05] than physical mixtures of triacylglycerol (PM), which further affect the amelioration efficiency in UC mice. Compared with PM, the damage of colonic tissues, intestinal barrier proteins, and inflammatory cytokines in STG showed better amelioration at the same dose of VitD. This study provides a comprehensive understanding of the mechanism of nutrients in different carriers and a solution for developing nutrients with high absorption efficiency.

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Section: Introductionmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

“…The detailed information of FA and TAG composition is reported in a previous study. 19 2.2. Designs of Animal Experiments and Diets.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Medium- and Long-Chain Structured Triacylglycerol on the Therapeutic Efficacy of Vitamin D on Ulcerative Colitis: A Consideration for Efficient Lipid Delivery Systems

Guo

Wang

et al. 2023

J. Agric. Food Chem.

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“…Liu and Li [ 132 , 133 ] found that medium- to long-chain DAG can be used to produce Pickering emulsions and high-internal-phase emulsions, thereby improving the stability of the emulsion, which enables the use of DAG emulsions in the preparation of low-calorie margarine, spreadable sauce, and cosmetics. Guo et al [ 134 ] recently used an MLCT-based emulsion system loaded with vitamin D to perform in vitro and in vivo digestion experiments, which demonstrated the improved bioavailability of vitamin D. Studies have demonstrated the possibility of preparing emulsions with diglycerol as an emulsifier and preparing emulsions loaded with easily oxidized structural oils. Currently, the application of SLs in emulsion systems is attracting increasing attention.…”

Section: Future Applications Of Sls In Food Systemsmentioning

confidence: 99%

Future of Structured Lipids: Enzymatic Synthesis and Their New Applications in Food Systems

Zhou

Lee

Mao

et al. 2022

Foods

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Structured lipids (SLs) refer to a new type of functional lipid obtained by modifying natural triacylglycerol (TAG) through the restructuring of fatty acids, thereby altering the composition, structure, and distribution of fatty acids attached to the glycerol backbones. Due to the unique functional characteristics of SLs (easy to absorb, low in calories, reduced serum TAG, etc.), there is increasing interest in the research and application of SLs. SLs were initially prepared using chemical methods. With the wide application of enzymes in industries and the advantages of enzymatic synthesis (mild reaction conditions, high catalytic efficiency, environmental friendliness, etc.), synthesis of SLs using lipase has aroused great interest. This review summarizes the reaction system of SL production and introduces the enzymatic synthesis and application of some of the latest SLs discussed/developed in recent years, including medium- to long-chain triacylglycerol (MLCT), diacylglycerol (DAG), EPA- and DHA-enriched TAG, human milk fat substitutes, and esterified propoxylated glycerol (EPG). Lastly, several new ways of applying SLs (powdered oil, DAG plastic fat, inert gas spray oil, and emulsion) in the future food industry are also highlighted.

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Synthesis of eicosapentaenoic acid‐enriched medium‐ and long‐chain triglyceride by lipase‐catalyzed transesterification: a novel strategy for clinical nutrition intervention

et al. 2023

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BACKGROUND Eicosapentaenoic acid (EPA) has been recognized as a promising nutrient to improve therapeutic efficacy for cancer patients. Nevertheless, there are certain limitations to the application of EPA due to its structural characteristics. To maximize the nutritive value of EPA, a type of medium‐ and long‐chain triacylglycerol (MLCT) enriched with EPA was designed and synthesized using the lipase‐catalyzed transesterification of medium‐chain triglyceride (MCT) and EPA‐enriched fish oil (FO). RESULTS The optimum synthesis conditions for EPA‐enriched MLCT used Lipozyme RM as catalyst, and had a substrate mass ratio (MCT/EPA‐enriched FO) of 3:1, lipase loading of 80 g kg−1, a reaction temperature of 60 °C, and a reaction time of 6 h. The MLCT content was as high as 80.79% after the transesterification reaction and the purification, and the content of MLCT containing EPA accounted for 70.21%. The distribution of EPA at the sn‐2 position showed a significant increase in MLCT compared with the original substrate, from 18.89% to 26.93%. The in vitro digestion results demonstrated that MLCT had a significantly higher EPA bioaccessibility than the original substrate. CONCLUSION Eicosapentaenoic acid‐enriched MLCT was developed. This may provide a novel strategy for clinical nutritional intervention. © 2023 Society of Chemical Industry.

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Medium and long-chain structured triacylglycerol enhances vitamin D bioavailability in an emulsion-based delivery system: combination of in vitro and in vivo studies

Abstract: Vitamin D (VitD) is an essential fat-soluble micronutrient required for maintaining and regulating calcium homeostasis. Although sunlight can provide VitD, epidemiological studies indicate that VitD deficiency and insufficiency are widespread....

Cited by 14 publications

References 55 publications

Effects of Medium- and Long-Chain Structured Triacylglycerol on the Therapeutic Efficacy of Vitamin D on Ulcerative Colitis: A Consideration for Efficient Lipid Delivery Systems

Effects of Medium- and Long-Chain Structured Triacylglycerol on the Therapeutic Efficacy of Vitamin D on Ulcerative Colitis: A Consideration for Efficient Lipid Delivery Systems

Future of Structured Lipids: Enzymatic Synthesis and Their New Applications in Food Systems

Synthesis of eicosapentaenoic acid‐enriched medium‐ and long‐chain triglyceride by lipase‐catalyzed transesterification: a novel strategy for clinical nutrition intervention

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