Medium-chain α-monoglycerides improves productive performance and egg quality in aged hens associated with gut microbiota modulation

Liu, Tao; Tang, Jun; Feng, Fengqin

doi:10.1016/j.psj.2020.07.049

Cited by 24 publications

(22 citation statements)

References 43 publications

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“…There is growing evidence that medium-chain fatty acid glyceride-based food additives can modulate the gut microbiota in mice and affect their health [ 14 , 15 , 16 , 17 , 18 ]. Originally, GMC was a medium-chain fatty acid glyceride food preservative.…”

Section: Discussionmentioning

confidence: 99%

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

2021

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Glycerol monocaprylate (GMC) is a glycerol derivative of medium-chain fatty acids (MCFAs) and is widely used as a preservative in food processing. However, GMC and its hydrolytic acid (octylic acid) have antibacterial properties that may affect the physiology and intestinal microecology of the human body. Therefore, in this study, the effects of two different dosages of GMC (150 and 1600 mg kg−1) on glucose, lipid metabolism, inflammation, and intestinal microecology of normal diet-fed C57BL/6 mice were comprehensively investigated. The obtained results showed that the level of triglycerides (TGs) in the low-dose group down-regulated significantly, and the anti-inflammatory cytokine interleukin 10 (IL-10) significantly increased, while the pro-inflammatory cytokines monocyte chemotactic protein 1 (MCP-1) and interleukin 1beta (IL-1β) in the high-dose group were significantly decreased. Importantly, GMC promoted the α-diversity of gut microbiota in normal-diet-fed mice, regardless of dosages. Additionally, it was found that the low-dose treatment of GMC significantly increased the abundance of Lactobacillus, while the high-dose treatment of GMC significantly increased the abundance of SCFA-producers such as Clostridiales, Lachnospiraceae, and Ruminococcus. Moreover, the content of short-chain fatty acids (SCFAs) was significantly increased by GMC supplementation. Thus, our research provides a novel insight into the effects of GMC on gut microbiota and physiological characteristics.

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Section: Discussionmentioning

confidence: 99%

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

2021

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“…At the phylum level, the gut microbiota of chickens includes hundreds of species, including microbial species dominated by Firmicutes, Bacteroides , Proteobacteria, and Actinomycetes [ 65 , 66 ]. Oil additives such as α-linolenic acid (ALA), DHA, and glycerin and its derivatives (such as glycerol monocaprylate and glycerol monolaurate) exert a positive effect on the intestinal microbial composition, egg production performance, egg quality (e.g., egg weight and egg yolk FA composition), reproductive performance, and body health of laying hens, which indicates the potential role of dietary oils in improving the microbial community, lipid metabolism, and health of laying hens [ 67 , 68 , 69 , 70 ]. For example, studies have found that the addition of linseed oil and algae oil to the diet increases the types of Firmicutes (such as Faeculus , Clostridium, and Ruminococcus ) microorganisms, and these microorganisms are closely related to FA metabolism [ 68 , 69 ].…”

Section: Mechanism Underlying the Effects Of Dietary Oils On The Production Performance And Egg Quality Of Laying Hensmentioning

confidence: 99%

Effect of Oils in Feed on the Production Performance and Egg Quality of Laying Hens

Gao

Zhang

et al. 2021

Animals

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With the development of a large-scale and intensive production industry, the number of laying hens in China is rapidly increasing. Oils, as an important source of essential fatty acids, can be added to the diet to effectively improve the production performance and absorption of other nutrients. The present review discusses the practical application of different types and qualities of oils in poultry diets and studies the critical effects of these oils on production performance, such as the egg weight, feed intake, feed conversion ratio (FCR), and various egg quality parameters, including the albumen height, Haugh units, yolk color, and saturated/unsaturated fatty acids. This article reviews the effects of different dietary oil sources on the production performance and egg quality of laying hens and their potential functional mechanisms and provides a reference for the selection of different sources of oils to include in the diet with the aim of improving egg production. This review thus provides a reference for the application of oils to the diets of laying hens. Future studies are needed to determine how poultry products can be produced with the appropriate proper oils in the diet and without negative effects on production performance and egg quality.

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“…8 Inclusion of GML and glycerol monodecanoate (GMD) mixture in the diet of aged hens improves egg-laying performance, feed efficiency and egg quality associated with gut microbiota modulation. 24 The gut microbiota alteration of mice by different dosages of GML supplementation may exert a different effect on systemic low-grade inflammation, glucose and lipid metabolism. 25,26 Our previous studies demonstrated that regulation of gut microbiota and its metabolites by dietary GML and MG mixture (GML and GMD) showed a close positive relationship with the enhanced productive performance, feed utilization, and meat and egg quality of poultry.…”

Section: Introductionmentioning

confidence: 99%

Dietary medium‐chain 1‐monoglycerides modulates the community and function of cecal microbiota of broilers

Liu

Guo

et al. 2021

J Sci Food Agric

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BACKGROUND: Medium-chain monoglycerides (MGs) are a group of 1-monoglycerides of medium-chain fatty acids with strong antibacterial activity, which may influence the gut microbiota in the diet of broilers. The present study evaluated the effects of mixed MGs on the community and function of gut microbiota in broilers. A total of 528 newly hatched male yellow feathered broiler chicks were weighed and randomly assigned into four groups, including a basal diet (CON), a basal diet containing 300 mg kg −1 MG (MG300), 450 mg kg −1 MG (MG450), or 600 mg kg −1 MG (MG600). RESULTS:The cecal acetic acid, propionic acid, butyric acid, isobutyric acid, isovaleric acid and total short-chain fatty acid of broilers in the MG-containing groups were notably increased compared with the CON group. Dietary MG selectively increased the relative abundance of Bifidobacteriaceae, Bacteroides and an unclassified genus of Lachnospiraceae family, but decreased the proportion of an unclassified genus of Barnesiellaceae and a norank genus of Flavobacteriaceae family in the cecum of broilers. Functional prediction revealed that MG supplementation enriched the microbial gene abundance of amino acid metabolism and carbohydrate metabolism, while depleted the gene abundance of fat metabolism and energy metabolism. Moreover, the modulation of gut microbiota by MG supplementation was closely correlated with the alteration of muscle amino acids. CONCLUSION: Dietary MGs altered the gut microbiota community structure and metabolites, and modulated the gene abundance of microbial metabolism pathways in the cecum of broilers, which may further influence the growth performance, nutrient utilization and meat quality of the host.

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Medium-chain α-monoglycerides improves productive performance and egg quality in aged hens associated with gut microbiota modulation

Cited by 24 publications

References 43 publications

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

Effect of Oils in Feed on the Production Performance and Egg Quality of Laying Hens

Dietary medium‐chain 1‐monoglycerides modulates the community and function of cecal microbiota of broilers

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