Medullary thyroid carcinoma

Jaber, Tania; Dadu, Ramona; Hu, Mimi I.

doi:10.1097/med.0000000000000662

Cited by 18 publications

(14 citation statements)

References 52 publications

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“…The patient's mother also had a history of surgery for MTC. MTC accounts for about 3%-4% of thyroid cancers 11 (unfortunately, genetic testing was not performed in this patient). There are about 20% of MTC is inherited, mainly by mutations in the RET proto-oncogene 11 .…”

Section: Discussionmentioning

confidence: 94%

“…MTC accounts for about 3%-4% of thyroid cancers 11 (unfortunately, genetic testing was not performed in this patient). There are about 20% of MTC is inherited, mainly by mutations in the RET proto-oncogene 11 . It can manifest as multiple endocrine neoplasia syndrome type 2, which can present MTC and pheochromocytoma occurred simultaneously 12 .…”

Section: Discussionmentioning

confidence: 94%

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Takotsubo syndrome induced by pheochromocytoma activation after resection of medullary thyroid carcinoma: a case report

Fang,

Kang,

Zhu

2023

Preprint

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Background Medullary thyroid carcinoma (MTC) and pheochromocytoma are rare neuroendocrine tumors, which are diagnosed simultaneously in approximately 35% of patients. Heart failure and Takotsubo Syndrome (TTS) are rare and life-threatening cardiovascular complications of pheochromocytoma. Case presentation: A 42-year-old woman was admitted to the hospital for surgery because of a thyroid nodule detected on physical examination. After surgery, she presented with acute heart failure in the general ward. The clinical manifestations combined with electrocardiogram, echocardiography, coronary angiography, and myocardial enzyme examination were consistent with the diagnosis of TTS. Postoperative abdominal enhanced CT and catecholamine levels at the time of heart failure supported that acute heart failure and TTS are due to enhanced adrenal pheochromocytoma activity. Conclusions MTC may be complicated with pheochromocytoma. Preoperative examination should be completed. It is recommended to perform pheochromocytoma surgery before MTC resection. In addition, acute heart failure and TTS are rare and serious complications of pheochromocytoma. Further studies are needed on the treatment and pathogenesis of TTS.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Takotsubo syndrome induced by pheochromocytoma activation after resection of medullary thyroid carcinoma: a case report

Fang,

Kang,

Zhu

2023

Preprint

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“…The cholecystokinin-2 receptor (CCK2R) belongs to this group of targets and is overexpressed in different types of neoplasms, such as medullary thyroid carcinoma (MTC) and small cell lung cancer [ 2 , 3 ]. MTC is a neoplasm with low incidence but connected with limitations in sensitivity and specificity of diagnostic imaging procedures, as well as lack of effective treatment strategies [ 4 , 5 ]. The main treatment strategy at initial diagnosis is surgical intervention consisting of total thyroidectomy with lymphadenectomy.…”

Section: Introductionmentioning

confidence: 99%

Effects of Side Chain and Peptide Bond Modifications on the Targeting Properties of Stabilized Minigastrin Analogs

et al. 2023

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Different attempts have been made in the past two decades to develop radiolabeled peptide conjugates with enhanced pharmacokinetic properties in order to improve the application for tumor imaging and peptide receptor radionuclide therapy (PRRT), which targets the cholecystokinin-2 receptor (CCK2R). In this paper, the influence of different side chain and peptide bond modifications has been explored for the minigastrin analog DOTA-DGlu-Ala-Tyr-Gly-Trp-(N-Me)Nle-Asp-1Nal-NH2 (DOTA-MGS5). Based on this lead structure, five new derivatives were synthesized for radiolabeling with trivalent radiometals. Different chemical and biological properties of the new derivatives were analyzed. Receptor interaction of the peptide derivatives and cell internalization of the radiolabeled peptides were studied in A431-CCK2R cells. The stability of the radiolabeled peptides in vivo was investigated using BALB/c mice. Tumor targeting of all 111In-labeled peptide conjugates, and of a selected compound radiolabeled with gallium-68 and lutetium-177, was evaluated in BALB/c nude mice xenografted with A431-CCK2R and A431-mock cells. All 111In-labeled conjugates, except [111In]In-DOTA-[Phe8]MGS5, showed a high resistance against enzymatic degradation. A high receptor affinity with IC50 values in the low nanomolar range was confirmed for most of the peptide derivatives. The specific cell internalization over time was 35.3–47.3% for all radiopeptides 4 h after incubation. Only [111In]In-DOTA-MGS5[NHCH3] exhibited a lower cell internalization of 6.6 ± 2.8%. An overall improved resistance against enzymatic degradation was confirmed in vivo. Of the radiopeptides studied, [111In]In-DOTA-[(N-Me)1Nal8]MGS5 showed the most promising targeting properties, with significantly increased accumulation of radioactivity in A431-CCK2R xenografts (48.1 ± 9.2% IA/g) and reduced accumulation of radioactivity in stomach (4.2 ± 0.5% IA/g). However, in comparison with DOTA-MGS5, a higher influence on the targeting properties was observed for the change of radiometal, resulting in a tumor uptake of 15.67 ± 2.21% IA/g for [68Ga]Ga-DOTA-[(N-Me)1Nal8]MGS5 and 35.13 ± 6.32% IA/g for [177Lu]Lu-DOTA-[(N-Me)1Nal8]MGS5.

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“…Medullary thyroid carcinoma (MTC), a malignant tumor arising from thyroid parafollicular C-cells characterized by the production of calcitonin (Ct), accounts for approximately 5% of all thyroid cancers ( 1 ). It can develop as a sporadic or hereditary familial tumor ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Oncologic outcomes of calcitonin-negative medullary thyroid carcinoma

Yue

Zhang

2022

Front. Endocrinol.

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ObjectiveCalcitonin (Ct)-negative medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor. This study aimed to clarify its incidence, clinicopathologic characteristics, management, and treatment outcome.MethodsWe retrospectively analyzed data of patients with primary MTC. Patients were divided into two groups according to the preoperative serum Ct level (Ct-negative and Ct-positive). The demographic, pathologic, and molecular characteristics, and treatment outcomes were compared between the two groups. In the Ct-negative group, we analyzed the association between the operation type and treatment outcome.ResultsOf the total 312 patients, 24 were diagnosed with Ct-negative MTC. The rate of lymph node metastasis was significantly higher in the Ct-positive than in the Ct-negative group (47.9% vs. 0%, p<0.001). The proportion of patients with Ki-67 ≤10% was significantly higher in the Ct-negative than in the Ct-positive group (87.5% vs. 38.2%, p<0.001). Excellent response was achieved by 91.7% and 34.7% of patients in the Ct-negative and Ct-positive groups, respectively (p<0.001). In the Ct-negative group, excellent response was achieved by all female patients, but only 50% of male patients.ConclusionsCt-negative MTC is rare and unlikely to develop lymph node metastasis. Unilateral lobectomy tends to provide a satisfactory chance of excellent response; however, this requires further validation.

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Medullary thyroid carcinoma

Cited by 18 publications

References 52 publications

Takotsubo syndrome induced by pheochromocytoma activation after resection of medullary thyroid carcinoma: a case report

Takotsubo syndrome induced by pheochromocytoma activation after resection of medullary thyroid carcinoma: a case report

Effects of Side Chain and Peptide Bond Modifications on the Targeting Properties of Stabilized Minigastrin Analogs

Oncologic outcomes of calcitonin-negative medullary thyroid carcinoma

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