2017
DOI: 10.1007/s00066-017-1235-5
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Medulloblastoma in adults

Abstract: The combined modality treatment showed a good outcome in adults with medulloblastoma. Treatment time was revealed to be prognostic and should be kept as short as possible.

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Cited by 13 publications
(2 citation statements)
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“…12 MB with SHH subtype is associated with desmoplastic histology in the vast majority of reported cases, including pediatric and most adult patients, and has been associated with better prognostic outcomes. 13 Moreover, loss of heterozygosity (LOH) of PTCH1 has been associated with prolonged progression-free survival in a setting of second-line therapy with vismodegib, whereas in the same setting, mutations in the SHH pathway downstream to SMO did not respond to the treatment. 14 The patient presented in this case has a nonsense mutation in position R135* of PTCH1 and mutation allele frequency of 97%, which could be an indication of LOH.…”
Section: Discussionmentioning
confidence: 99%
“…12 MB with SHH subtype is associated with desmoplastic histology in the vast majority of reported cases, including pediatric and most adult patients, and has been associated with better prognostic outcomes. 13 Moreover, loss of heterozygosity (LOH) of PTCH1 has been associated with prolonged progression-free survival in a setting of second-line therapy with vismodegib, whereas in the same setting, mutations in the SHH pathway downstream to SMO did not respond to the treatment. 14 The patient presented in this case has a nonsense mutation in position R135* of PTCH1 and mutation allele frequency of 97%, which could be an indication of LOH.…”
Section: Discussionmentioning
confidence: 99%
“…When the extension of the tumor involves the sixth cranial nerve or it is a result of hydrocephalus, patients may present with double or blurred vision. Exceptionally, these patients have normal neurological examination [8][9][10][11][12][13] .…”
Section: Introductionmentioning
confidence: 89%