Meet Me in the Middle

The Role of Lymphatic Vascular Function in Metabolic Disorders

“…These cells then differentiate into LECs, and migrate to establish primitive lymphatic vessels, identified as the jugular lymph sac, by E11.5 . However, more recent evidence has also demonstrated the contribution of other tissue-associated vascular progenitor cells as well as non-endothelial cells to early lymphatic vasculature morphogenesis and the development of the primitive lymphatic vascular network (Bernier-Latmani et al, 2015;Klotz et al, 2015;Martinez-Corral et al, 2015;Stanczuk et al, 2015;Kazenwadel and Harvey, 2016). Several critical signaling pathways are involved in this process including VEGF-C/-D activation of the VEGFR-3 receptor tyrosine kinase, regulation of key downstream gene expression by SOX18, PROX1, GATA2, and FOXC2 transcription factors, as well as Notch1, FGF2/FGFR1, ANG2/TIE2, and EFNB2/EPHB4 signaling, which have been previously reviewed in great detail in articles we refer to the reader (Tammela and Alitalo, 2010;Schulte-Merker et al, 2011;Yang and Oliver, 2014;Zheng et al, 2014).…”

Single nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium

“…His work on other mammals reinforced the idea that the lymphatic system develops from a mesenchymal cell population characterized by the presence of several vacuoles 9 . The centripetal and the centrifugal theories have been debated for over a century 10,11 . Although many works reported the venous origin of the lymphatic progenitors, only very recently has the discovery of new cell lineages contributing to organ-specific lymphatics changed the understanding of LEC origin 12 .…”