Meet the human metabolome

Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics

“…The metabolome is generally referred to as the complete set of metabolites found in a cell, organ, tissue, bio uid or organism. 65 …”

“…66 Small changes in genes or protein activity can have large consequences in metabolite concentrations. 65 At the same time, metabolites may have regulatory e ects on gene or protein expression. An illustration of the Omics cascade is shown in Figure 1.5.…”

Proteomics and the Human Metabolome Project

“…Unlike the genome, which is a clearly defined entity, the metabolome (like the proteome) has many definitions for many different people. This appears to be a source for both confusion and dispute within the metabolomics community [16]. Hopefully, the introduction of data standards and the establishment of dedicated bodies, such as the Metabolomics Society, will go a long way to resolving this issue.…”

“…No doubt there are many other sanguine predictions about the prospects for metabolomics and the human metabolome [16]. However, it is important to remember that metabolomics will not be a panacea to solve all (or even most) biomedical problems.…”

The Search for New Prostate Cancer Biomarkers Continues

“…Recently, the human metabolome has been published (8 ), along with a commentary on its potential for diagnostic purposes (9 ). The human metabolome consists of approximately 2500 metabolites (www.hmdb.ca).…”