Meeting report: Mechanisms of bone loss: Rheumatoid arthritis, periodontal disease and osteoporosis

Hayward, Marshall A.; Fiedler-Nagy, Ch.

doi:10.1007/bf02009053

Cited by 28 publications

(10 citation statements)

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“…The distinct underlying immunopathology of both diseases is not yet completely understood. However, it has been suggested that there are some similarities between the tissue destruction features of RA and periodontal disease [3,8,9,11,15,16].…”

Section: Resultsmentioning

confidence: 99%

Clinical and Immunological Characteristics of Patients with Rheumatoid Arthritis and Periodontal Disease.

Yavuzyilmaz

Yamalik

Calguner

et al. 1992

The Journal of Nihon University School of Dentistry

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Section: Resultsmentioning

confidence: 99%

Clinical and Immunological Characteristics of Patients with Rheumatoid Arthritis and Periodontal Disease.

Yavuzyilmaz

Yamalik

Calguner

et al. 1992

The Journal of Nihon University School of Dentistry

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“…There are some similarities between the local tissue destruction features of RA and periodontal disease manifested in active tissue destruction of both diseases by the presence of similar cells infiltration as well as inflammatory mediators [20]. …”

Section: Discussionmentioning

confidence: 99%

Salivary TNFα levels in groups of subjects with rheumatoid arthritis and chronic periodontitis

et al. 2017

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BackgroundRheumatoid arthritis (RA) and chronic periodontitis are the most common chronic inflammatory diseases with significant pathological and clinical similarities. Numerous studies have indicated a relationship between rheumatoid arthritis and periodontal disease. The aim of this study was to compare the TNF-α levels in saliva among patients with Rheumatoid arthritis (RA) and chronic periodontitis as well as healthy subjects.MethodsOne hundred and seventy-one patients were enrolled in this cross-sectional study. Fifty-seven patients diagnosed of RA, 57 patients with chronic periodontitis and 57 healthy subjects. These patients have been examined with regard to TNF-α level from salivary samples. Their teeth were examined with regard to Plaque Index , Gingival Index, probing depth and clinical attachment level.All patients were non-smokers.ResultsThe results revealed a significant difference in all periodontal parameters among the three groups. The chronic periodontitis group showed a significantly higher value in all clinical periodontal parameters in comparison to both the RA and healthy groups. No significant difference was found between salivary TNF-α level among the three study groups.ConclusionsPatients with chronic periodontitis had the highest periodontal indices. However there was no significant difference regarding the level of salivary TNF-α. Hence, suppression of proinflammatory cytokines might prove beneficial in suppressing periodontal diseases among RA patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2341-7) contains supplementary material, which is available to authorized users.

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“…While osteoclasts play a critical role in the physiological bone remodeling process, they are also engaged in pathological bone resorption in bone lytic diseases, such as rheumatoid arthritis, osteomyelitis, osteoporosis and periodontal disease [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo

Franco

Kajiya

Nakanishi³

et al. 2011

Experimental Cell Research

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Tetracycline antibiotics, including Doxycycline (DOX), have been used to treat bone resorptive diseases, partially because of their activity to suppress osteoclastogenesis induced by receptor activator of nuclear factor kappa B ligand (RANKL). However, their precise inhibitory mechanism remains unclear. Therefore, the present study examined the effect of Dox on osteoclastogenesis signaling induced by RANKL, both in vitro and in vivo. Although Dox inhibited RANKL-induced osteoclastogenesis and down-modulated the mRNA expression of functional osteoclast markers, including tartrate-resistant acid phosphatase (TRAP) and cathepsin K, Dox neither affected RANKL-induced MAPKs phosphorylation nor NFATc1 gene expression in RAW264.7 murine monocytic cells. Gelatin zymography and Western blot analyses showed that Dox down-regulated the enzyme activity of RANKL-induced MMP-9, but without affecting its protein expression. Furthermore, MMP-9 enzyme inhibitor also attenuated both RANKL-induced osteoclastogenesis and up-regulation of TRAP and cathepsin K mRNA expression, indicating that MMP-9 enzyme action is engaged in the promotion of RANKL-induced osteoclstogenesis. Finally, Dox treatment abrogated RANKL-induced osteoclastogenesis and TRAP activity in mouse calvaria along with the suppression of MMP9 enzyme activity, again without affecting the expression of MMP9 protein. These findings suggested that Dox inhibits RANKL-induced osteoclastogenesis by its inhibitory effect on MMP-9 enzyme activity independent of the MAPK-NFATc1 signaling cascade.

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Meeting report: Mechanisms of bone loss: Rheumatoid arthritis, periodontal disease and osteoporosis

Cited by 28 publications

References 0 publications

Clinical and Immunological Characteristics of Patients with Rheumatoid Arthritis and Periodontal Disease.

Clinical and Immunological Characteristics of Patients with Rheumatoid Arthritis and Periodontal Disease.

Salivary TNFα levels in groups of subjects with rheumatoid arthritis and chronic periodontitis

Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo

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