Meetings at the Edge with Adam: A Man for All Seasons?

Structure-Activity Relationships of MDMA-Like Substances

“…As a consequence of these and other studies that have indicated that MDMA has a pharmacology different from the hallucinogenic amphetamines, and in view of the reports by certain psychiatrists (Greer and Tolbert 1986;Wolfson 1986) that MDMA could facilitate the process of psychotherapy, it was hypothesized that MDMA and related compounds represent a new pharmacological class, with as yet unexplored potential as psychiatric drugs (Nichols 1986;Nichols et al 1986). This class of drugs has been called entactogens.…”

Effects of MDMA on socioemotional feelings, authenticity, and autobiographical disclosure in healthy volunteers in a controlled setting

“…closeness! (Wolfson,!1986;!Greer!and!Tolbert,!1986).!More!recently,!clinical!trials!have!tested! MDMA!as!a!therapeutic!adjunct!in!patients!with!postJtraumatic!stress!disorder!…”

History of MDMA

“…There were some positive changes described, and in some cases there was no improvement observed. One extensive report has appeared in considerable detail of a clinical application [50], and several surveys have appeared of MDMA users. These include retrospective psychological interviews [51] and an evaluation of sexual aspects of the drug's effects [52].…”