Megestrol acetate in advanced, progressive, hormone-insensitive cancer. Effects on the quality of life: a placebo-controlled, randomised, multicentre trial

Westman, Gunnar; Bergman, Bengt; Albertsson, Maria; Kadar, Lianna; Gustavsson, G; Thaning, Lars; Andersson, Magnus; Straumits, A; Jeppson, Bengt; Lindén, Carl-Johan; Ewers, Sven-Börje; Andersson, H; Mercke, Claes; Hafström, Larsolof; Birck, O; Orgum, Petter

doi:10.1016/s0959-8049(98)00398-0

Cited by 52 publications

(48 citation statements)

References 34 publications

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“…5, the means of the body weight of megestrol acetate-treated animals were higher than that of controls from week 4 of treatment, and the differences were statistically significant in week 5 and week 6. In this aspect, the effect of megestrol acetate on nude mice appear to be similar to that of human studies (28,38,42,63,64). Preliminary studies suggest that progestational agents down-regulate interleukin-6, an inflammatory cytokine widely implicated in cancer-associated anorexia and weight loss.…”

Section: Discussionsupporting

confidence: 52%

“…Although no significant survival advantage was demonstrated (62), beneficial effects on appetite and body weight have been observed in megestrol acetatetreated cancer patients in the majority of studies (28,38,42,63,64). In this study, as shown in Fig.…”

Section: Discussionmentioning

confidence: 63%

“…Megestrol acetate has been used clinically for the treatment of malignancies, including endometrial carcinoma, ovarian cancer, breast cancer, prostate cancer, renal cell carcinoma, and malignant melanoma for Ͼ30 years (28,38,39). Treatment with Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies have also been designed to investigate the effect of megestrol acetate treatment on appetite, body weight, quality of life, and survival (28,42). Although no significant survival advantage was demonstrated (62), beneficial effects on appetite and body weight have been observed in megestrol acetatetreated cancer patients in the majority of studies (28,38,42,63,64).…”

Section: Discussionmentioning

confidence: 99%

“…A small controlled trial has shown that megestrol acetate favorably influence the course of advance HCC and improve patient survival (27). Quite apart from its antiestrogen mechanisms, megestrol acetate impacts positively on the quality of life in patients with advanced malignancy (28).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Megestrol Acetate on Growth of HepG2 Cells In vitro and In vivo

Zhang¹,

Chow

2004

Clinical Cancer Research

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Purpose: Hepatocellular carcinoma (HCC) is generally considered as a sex hormone-dependent tumor, and hormonal therapy has been proposed as a strategy for the treatment of HCC. The aim of the study is to investigate the effect of megestrol acetate, a synthetic progesteronal agent, on growth of HepG2 cells in vitro and in vivo.Experimental Design: Cell growth in vitro was assessed by a colormetric method, and cell growth in vivo was assessed by tumor volumetrics. Results: Megestrol acetate was shown to inhibit the growth of HepG2 cells in vitro in dose-and time-dependent manners with an IC 50 of 260 M (24-h incubation).The growth of HepG2 cell-transplanted tumors in nude mice was also inhibited by i.p. injection of megestrol acetate (10 mg/ kg/day). The tumor volumes of the megestrol acetate-treated group regressed to 59% of controls by week 6 and to 41% of controls by week 13. Apoptosis following G 1 arrest was observed in megestrol acetate-treated cells and may be a mechanism through which megestrol acetate inhibits HepG2 cells. Megestrol acetate was also demonstrated to have a beneficial effect on the weight gain of tumor-bearing nude mice, and the mean weight of the megestrol acetate-treated animals was higher than that of controls from week 4 of the treatment period, and the differences were statistically significant in week 5 and 6 (P < 0.05, compared with controls). No significant survival advantage was, however, demonstrated in the treatment group.Conclusions: This study showed that megestrol acetate inhibited the growth of HepG2 cells grown in vitro and in vivo. These data provide useful information for clinical study of megestrol acetate for the treatment of HCC.

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