Meibomian Gland Dysfunction in a Hospital-Based Population in Central India

Chatterjee, Samrat; Agrawal, Deepshikha; Sharma, Arpit

doi:10.1097/ico.0000000000002217

Cited by 17 publications

(24 citation statements)

References 43 publications

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“…13,14 Therefore, it can be expected that older individuals will have a higher prevalence rate of MGD. 15 Due to the limited age range and small number of male subjects in our study, we were unable to compare the prevalence of MGD between age and gender. Since MGD is a very common eye disorder, an objective diagnostic tool is extremely helpful for ophthalmic healthcare workers to allow patients to visualize the severity of MGD and to individualize the treatment strategy.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of Meibomian Gland Dysfunction Among Ophthalmic Healthcare Workers

Chan¹,

Chuang²,

Wong³

2021

OPTH

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To evaluate the prevalence of meibomian gland dysfunction (MGD) among ophthalmic healthcare workers. Setting: A tertiary ophthalmic center. Design: Prospective, observational study. Methods: Forty-four volunteer ophthalmologists and ophthalmic nurses were recruited. Information including demographics, contact lens wear, history of refractive surgery and symptom score based on Standardized Patient Evaluation of Eye Dryness (SPEED) II Questionnaire for Dry Eye Disease/Ocular Surface Disease were recorded. Lipid layer thickness (LLT), meibomian glands dropout and dilation grades, and proportion of partial blinking were evaluated using an ocular surface interferometer with dynamic meibomian imaging (LipiView, Johnson & Johnson). Based on the chance of MGD, meibomian gland dropout and dilation, selected subjects also underwent treatment with a thermal pulsation system (LipiFlow, Johnson & Johnson) in one or both eyes. Results: Eighty-eight eyes of 44 volunteers were evaluated during the study period. The mean LLT was 60.0nm. Twenty-seven (61.4%) subjects had a 90% or high chance of MGD and their mean lower lid meibomian gland dropout and dilation grades were 1.2 and 1.7, respectively. Twenty-eight eyes of 16 volunteers received treatment with the thermal pulsation system. Following treatment, the mean LLT improved from 50.3nm to 61.0nm (Wilcoxon's signed rank test, p=0.001). Conclusion: Despite being more knowledgeable to MGD and more accessible to treatment, MGD is a highly prevalent condition among ophthalmic healthcare workers, with a 61.4% prevalence among the recruited subjects. This is similar to reported prevalence in Asian populations of up to 74.5%. Targeted therapy based on dynamic meibomian imaging is effective in improving both objective and subjective measures of MGD.

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Section: Discussionmentioning

confidence: 93%

Evaluation of Meibomian Gland Dysfunction Among Ophthalmic Healthcare Workers

Chan¹,

Chuang²,

Wong³

2021

OPTH

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“…In a previous study on meibomian gland dysfunction, we observed fewer symptoms among elderly patients, even though there was a greater amount of lid margin changes in them. [ 26 ] Symptom perceptions in elderly subjects may be less due to changes in corneal nerve morphology and reduction in ocular surface sensitivity with increasing age. [ 27 ]…”

Section: Discussionmentioning

confidence: 99%

Prevalence of symptoms of dry eye disease in an urban Indian population

Chatterjee¹,

Agrawal²,

Sanowar³

et al. 2021

Indian Journal of Ophthalmology

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Purpose: The aim of this study was to estimate the prevalence of symptoms of dry eye disease (DED) in an urban population in India. Methods: In this cross-sectional study, a two-stage cluster sampling procedure was conducted across 50 municipal wards in the city of Raipur, India, between December 2019 and February 2020, to include 2500 households. Interviewers collected demographic and lifestyle data from participants aged ≥20 years. DED symptoms were assessed using a standard six-item validated questionnaire. The presence of one or more of the six dry eye symptoms often or all the time was considered positive for DED symptoms. Results: In this study, 2378 people completed the survey of whom 1397 (58.7%) were males and 981 (41.3%) were females. The crude and overall age-adjusted prevalence for any positive symptom was 6.5% and 6.8% (95% CI: 5.8–7.8%), respectively. The commonest symptom was red eyes (2.8%) followed by burning sensation (1.8%), foreign body sensation (1.7%), dry eyes (1.2%), gummy eyes (1.2%), and crusts on eyelashes (0.8%). The associated risk factors were female sex, use of digital display, smoking and stay in an air-conditioned environment. Conclusion: The prevalence of DED symptoms in this urban Indian population was less than the prevalence reported in most other population-based studies from outside India, and lower than other hospital-based studies from India. Hence, DED prevalence in India is either lower than current estimates or is non-uniform in distribution.

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“…Epidemiological evidence shows that the prevalence of MGD ranges from 3.5% to almost 70% in various countries, [ 1 ] and the data reported in Asian countries are generally higher than those reported in Western countries. [ 2 ] It is well established that MGD can not only cause ocular surface discomfort related to impaired meibomian gland (MG) function, but also give rise to intractable evaporative dry eye. [ 3 ] However, consensus regarding the optimal intervention strategy is lacking.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing the clinical outcomes of intense pulsed light for meibomian gland dysfunction

Chen

Chou

et al. 2021

Medicine

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To observe the clinical outcomes of intense pulsed light (IPL) for meibomian gland dysfunction (MGD) and identify its influencing factors. Forty-eight eyes of 48 patients with MGD were included. Subjects were followed up 5 times on day 1, day 15, day 30, day 45, and day 120, and underwent 3 sessions of the IPL treatment on day 1, day 15 and day 30. Gender, age, duration of MGD, time of video display terminal usage, and severity of MGD were recorded at baseline. At every visit, Ocular Surface Disease Index (OSDI), eyelid margin abnormality score, tear film breakup time, Schirmer I test (S ɪ t) and corneal fluorescein staining were recorded. The clinical parameters before and after 3 IPL treatments were compared. Univariate and multivariable logistic regression analyses were performed to explore influencing factors. Compared with baseline, the tear film breakup time was increased and the corneal fluorescein staining score and OSDI were significantly decreased on day 45 and day 120 (all P < .001). In univariate analysis, among the patients with a younger age (18–39 years), moderate MGD, higher baseline S ɪ t and higher baseline OSDI, the IPL treatment had a higher effective rate ( P = .032, .004, .024, and .014 respectively). The MGD severity was strongly associated with effective IPL, and patients with moderate MGD had an OR of 22.454 compared with the severe MGD patients (OR = 22.454, 95% CI: 2.890-174.436, P = .003). IPL effectively improves clinical symptoms and some signs in MGD patients. Age, MGD severity, baseline S ɪ t and baseline OSDI are potential factors that may influence the clinical outcomes of IPL. MGD severity is an independent influencing factor.

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Meibomian Gland Dysfunction in a Hospital-Based Population in Central India

Cited by 17 publications

References 43 publications

Evaluation of Meibomian Gland Dysfunction Among Ophthalmic Healthcare Workers

Evaluation of Meibomian Gland Dysfunction Among Ophthalmic Healthcare Workers

Prevalence of symptoms of dry eye disease in an urban Indian population

Factors influencing the clinical outcomes of intense pulsed light for meibomian gland dysfunction

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