Meiosis in Aspergillus nidulans: Another example for lacking synaptonemal complexes in the absence of crossover interference

Egel-Mitani, Michiko; Olson, Lauritz W.; Egel, Richard

doi:10.1111/j.1601-5223.1982.tb00870.x

Cited by 14 publications

(13 citation statements)

References 26 publications

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“…Although the SC is often considered to be a universal feature of meiosis, it is absent from several organisms, including Schizosaccharomyces pombe, Aspergillus nidulans, and Drosophila males (Rasmussen, 1973;Egel-Mitani et al, 1982;Molnar et al, 2003;Page and Hawley, 2004). In the absence of SCs, Drosophila males achieve homologous pairing and segregation in a special way rather than by meiotic recombination and chiasma formation (Page and Hawley, 2004).…”

Section: Synapsis Is Dispensable For Co Formation In Ricementioning

confidence: 99%

The Central Element Protein ZEP1 of the Synaptonemal Complex Regulates the Number of Crossovers during Meiosis in Rice

et al. 2010

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ZEP1, a transverse filament (TF) protein, is the rice (Oryza sativa) homolog of Arabidopsis thaliana ZYP1. In the Tos17-insertional zep1 mutants, homologous chromosomes align along the entire length of the chromosome, but the synaptonemal complex is not assembled in early prophase I. Crossovers are well formed, and 12 bivalents could be detected from diakinesis to metaphase I, which leads to equal chromosomal segregation in anaphase I. Moreover, the number of crossovers has a tendency to be increased compared with that in the wild type. These phenomena are different from the TF mutants identified so far in other organisms. Chiasma terminalization of the bivalent, which occurs frequently in the wild type, seldom occurred in zep1. Transmission electron micrographs and immunodetection using an antibody against ZEP1 showed that ZEP1 is the central element of the synaptonemal complex. Although PAIR2 and MER3 were loaded normally in zep1, their dissociation was delayed severely compared with the wild type. In addition, ZEP1 is reloaded onto chromosomes in early microspores as the chromosome decondense, suggesting that ZEP1 might have other biological functions during this process.

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Section: Synapsis Is Dispensable For Co Formation In Ricementioning

confidence: 99%

The Central Element Protein ZEP1 of the Synaptonemal Complex Regulates the Number of Crossovers during Meiosis in Rice

et al. 2010

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“…However, in e.g., Caenorhabditis elegans and Drosophila females SC formation occurs without DSB formation (Zickler and Kleckner, 2015). In Schizosaccharomyces pombe and Aspergillus nidulans no SCs become established and pairing occurs recombination-independent and recombination-mediated, respectively (Olson et al, 1978; Egel-Mitani et al, 1982; Bahler et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure and Dynamics of Synaptonemal Complex Components During Meiotic Pairing and Synapsis of Standard (A) and Accessory (B) Rye Chromosomes

et al. 2019

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During prophase I a meiosis-specific proteinaceous tripartite structure, the synaptonemal complex (SC), forms a scaffold to connect homologous chromosomes along their lengths. This process, called synapsis, is required in most organisms to promote recombination between homologs facilitating genetic variability and correct chromosome segregations during anaphase I. Recent studies in various organisms ranging from yeast to mammals identified several proteins involved in SC formation. However, the process of SC disassembly remains largely enigmatic. In this study we determined the structural changes during SC formation and disassembly in rye meiocytes containing accessory (B) chromosomes. The use of electron and super-resolution microscopy (3D-SIM) combined with immunohistochemistry and FISH allowed us to monitor the structural changes during prophase I. Visualization of the proteins ASY1, ZYP1, NSE4A, and HEI10 revealed an extensive SC remodeling during prophase I. The ultrastructural investigations of the dynamics of these four proteins showed that the SC disassembly is accompanied by the retraction of the lateral and axial elements from the central region of the SC. In addition, SC fragmentation and the formation of ball-like SC structures occur at late diakinesis. Moreover, we show that the SC composition of rye B chromosomes does not differ from that of the standard (A) chromosome complement. Our ultrastructural investigations indicate that the dynamic behavior of the studied proteins is involved in SC formation and synapsis. In addition, they fulfill also functions during desynapsis and chromosome condensation to realize proper recombination and homolog separation. We propose a model for the homologous chromosome behavior during prophase I based on the observed dynamics of ASY1, ZYP1, NSE4A, and HEI10.

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“…In fission yeast (Schizosaccharomyces pombe) and filamentous fungus Aspergillus nidulans, recombination-independent and recombination-mediated pairing occurs but SC is absent (Egel-Mitani et al 1982;Bähler et al 1993). In female Drosophila and Caenorhabditis elegans, pairing and synapsis occur independently of recombination, which then occurs later in the context of the SC (reviewed in Lake and Hawley 2012;Liu and Colaiácovo 2013;Rog and Dernburg 2013).…”

Section: Alternative Programsmentioning

confidence: 99%

Recombination, Pairing, and Synapsis of Homologs during Meiosis

Zickler

Kleckner

2015

Cold Spring Harb Perspect Biol

706

828

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Recombination is a prominent feature of meiosis in which it plays an important role in increasing genetic diversity during inheritance. Additionally, in most organisms, recombination also plays mechanical roles in chromosomal processes, most notably to mediate pairing of homologous chromosomes during prophase and, ultimately, to ensure regular segregation of homologous chromosomes when they separate at the first meiotic division. Recombinational interactions are also subject to important spatial patterning at both early and late stages. Recombination-mediated processes occur in physical and functional linkage with meiotic axial chromosome structure, with interplay in both directions, before, during, and after formation and dissolution of the synaptonemal complex (SC), a highly conserved meiosis-specific structure that links homolog axes along their lengths. These diverse processes also are integrated with recombination-independent interactions between homologous chromosomes, nonhomology-based chromosome couplings/clusterings, and diverse types of chromosome movement. This review provides an overview of these diverse processes and their interrelationships.

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Meiosis in Aspergillus nidulans: Another example for lacking synaptonemal complexes in the absence of crossover interference

Cited by 14 publications

References 26 publications

The Central Element Protein ZEP1 of the Synaptonemal Complex Regulates the Number of Crossovers during Meiosis in Rice

The Central Element Protein ZEP1 of the Synaptonemal Complex Regulates the Number of Crossovers during Meiosis in Rice

Ultrastructure and Dynamics of Synaptonemal Complex Components During Meiotic Pairing and Synapsis of Standard (A) and Accessory (B) Rye Chromosomes

Recombination, Pairing, and Synapsis of Homologs during Meiosis

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