2014
DOI: 10.1242/dev.097295
|View full text |Cite
|
Sign up to set email alerts
|

Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb

Abstract: Meis homeodomain transcription factors control cell proliferation, cell fate specification and differentiation in development and disease. Previous studies have largely focused on Meis contribution to the development of non-neuronal tissues. By contrast, Meis function in the brain is not well understood. Here, we provide evidence for a dual role of the Meis family protein Meis2 in adult olfactory bulb (OB) neurogenesis. Meis2 is strongly expressed in neuroblasts of the subventricular zone (SVZ) and rostral mig… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
159
0

Year Published

2014
2014
2022
2022

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 108 publications
(163 citation statements)
references
References 67 publications
4
159
0
Order By: Relevance
“…Alternatively, Meis1 could interact with a wide variety of TFs in the eye, including its own putative targets such as Sox2, Pax6 and Otx2, reinforcing their activity. The latter possibility is supported by the observation that the related Meis2 has been shown to interact at least with Otx2, Pax3, Pax6 and Pax7 (Agoston et al, 2014(Agoston et al, , 2012Agoston and Schulte, 2009). Alternatively, and based on the predominant presence of a 'Meis1-only' targeted sequence (m1, Fig.…”
Section: Discussionmentioning
confidence: 87%
“…Alternatively, Meis1 could interact with a wide variety of TFs in the eye, including its own putative targets such as Sox2, Pax6 and Otx2, reinforcing their activity. The latter possibility is supported by the observation that the related Meis2 has been shown to interact at least with Otx2, Pax3, Pax6 and Pax7 (Agoston et al, 2014(Agoston et al, , 2012Agoston and Schulte, 2009). Alternatively, and based on the predominant presence of a 'Meis1-only' targeted sequence (m1, Fig.…”
Section: Discussionmentioning
confidence: 87%
“…Of the Tuj1-expressing neuroblasts in the SVZ or RMS, 81.75±13.2% were immunoreactive for PBX1 and virtually all of these co-labeled for MEIS2 (Fig. 1G-I) (Agoston et al, 2014). Notably, the dentate gyrus of the hippocampus, which is the second major stem cell niche in the adult mouse brain, is devoid of Pbx1 transcripts or protein (Fig.…”
Section: Resultsmentioning
confidence: 94%
“…Mechanistically, PBX1 associates with members of the MEIS/PREP subclass of TALE-HD proteins, but can also form heteromeric complexes with HOX proteins, non-HOX HD-containing proteins, bHLH or PAX proteins (Ladam and Sagerström, 2014;Longobardi et al, 2014;). As we have recently shown, MEIS2 is an essential co-factor of the neurogenic transcription factor PAX6 and as such is required for the acquisition of a general neuronal fate in the SVZ and the subsequent differentiation of a subpopulation of these cells towards dopaminergic periglomerular neurons (Agoston et al, 2014;Brill et al, 2008;Hack et al, 2005;Kohwi et al, 2005Kohwi et al, , 2007.…”
Section: Introductionmentioning
confidence: 97%
“…Motif co-occurrence analysis (Fig. 2F) revealed an enriched association between the MORE or MORE+1 sites and motifs for various factors, such Meis transcription factors, which are important in neurogenesis (Agoston et al, 2014;Yamada et al, 2013), the DR1 motif for the Rar-Rxr or Pparg-Rxr heterodimers, and Runx1 and Foxd3. There is, however, selectivity as MORE sites associate with motifs for other nuclear receptors, notably the DR5 for Rar-Rxr, and sites for Nr5a2 and Nr2f1 (Coup-Tf1), as well as for Trp53 and Trp63, whereas MORE+1 sites are associated with motifs targeted by Tead1 and Rest, both of which have known functions in neurogenesis (Ballas and Mandel, 2005;Cao et al, 2008).…”
Section: Brn2 Directly Regulates Genes That Are Crucial For Neuronal mentioning
confidence: 99%