Melaleuca alternifolia  anthelmintic activity in gerbils experimentally infected by  Haemonchus contortus

Grando, Thirssa H.; Baldissera, Matheus D.; Gressler, Lucas T.; Sá, Mariangela Facco de; Bortoluzzi, Bruna N.; Schafer, Andressa S.; Ebling, Rafael Costa; Raffin, Renata Platcheck; Santos, Roberto C.V.; Stefani, Lenita M.; Vaucher, Rodrigo de Almeida; Leal, Marta L.R.; Monteiro, S. G.

doi:10.1016/j.exppara.2016.09.004

Cited by 34 publications

(19 citation statements)

References 37 publications

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“…O OE de Melaleuca alternifolia e seu composto majoritário, o terp-4-ol, não apresentaram toxicidade nas doses de 0,75 e 0,5 mL/kg, respectivamente, quando administrado por via oral em Meriones unguiculatus (gerbil) [31]. Em ovinos, o OE de Cymbopogon schoenanthus, nas doses de 180 e 320 mg/kg, não causou alterações bioquímicas ou hematológicas [43].…”

Section: Efeito Anti-helmíntico De óLeos Essenciaisunclassified

“…Alguns OE apresentaram resultados promissores in vitro, porém os resultados nem sempre se reproduzem nos testes in vivo [8,23,31,43]. Nos ensaios in vitro, os nematoides são expostos diretamente aos compostos bioativos, enquanto nos testes in vivo, a metabolização dos óleos pode diminuir a concentração dos biocompostos na corrente sanguínea e nos tecidos do trato gastrintestinal [26].…”

Section: Efeito Anti-helmíntico De óLeos Essenciaisunclassified

“…Estudos que avaliaram a atividade anti-helmíntica do OE de E. staigeriana nanoencapsulado utilizaram como biopolímero a quitosana [62,84] e um nanocarreador lipídico [31,32]. A definição da matriz a ser utilizada é de fundamental importância, pois fatores como eficiência de encapsulamento, liberação controlada do OE em uma faixa de pH abomasal (3,5-4,5) e tipo de formulação (liquido ou sólido) são fatores que podem inviabilizar a utilização do produto em ovinos e caprinos.…”

Section: Atividade Anti-helmintica De Compostos Isolados De óLeosunclassified

“…O nanoencapsulamento do OE de M. alternifolia com lipídeos não potencializou a atividade ovicida e larvicida sobre H. contortus. Provavelmente porque a liberação do óleo nanoencapsulado ocorre de maneira lenta e gradual, diferindo do óleo livre que rapidamente alcança concentrações elevadas [31]. A avaliação de OE nanoencapsulado em testes in vitro deve ser realizada com cautela, visto que o pH do meio pode influenciar a liberação controlada das substâncias, devendo os testes serem realizados em pH adequado e em um intervalo de tempo que permita a liberação do óleo carreado pelas nanoparticulas [31,84].…”

Section: Atividade Anti-helmintica De Compostos Isolados De óLeosunclassified

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Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

André

Ribeiro

Oliveira

et al. 2018

Acta Scientiae. Vet.

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Background: Gastrointestinal nematodes are one of the major health and economic problem of sheep and goats in the world. The control of these nematodes is carried out conventionally with synthetic anthelminths, which favored the selection of gastrointestinal nematode (GIN) populations multiresistant to anthelmintics. The emergence of anthelmintic resistance has stimulated the search for new alternatives to control small ruminant GIN, standing out the use of plants and their bioactives compounds, such as essential oils (EO). The objective of this review was to present the main characteristics and anthelmintic activity of EO, their isolated compounds and drug delivery systems in the control of GIN.Review: Essential oils are a complex blend of bioactive compounds with volatile, lipophilic, usually odoriferous and liquid substances. EO are composed of terpenes, terpenoids, aromatic and aliphatic constituents. EO has various pharmacological activities of interest in preventive veterinary medicine such as antibacterials, antifungals, anticoccicids, insecticides and anthelmintics. In vitro and in vivo tests are used to validate the anthelmintic activity of EO on GIN. In vitro tests are low cost screening tests that allow the evaluation of the anthelmintic activity of a large amount of bioactive compounds on eggs, first (L1) and third stage larvae (L3), and adult nematodes. The antiparasitic effect of EO is related to its main compound or to the interaction of the compounds. These bioactive compounds penetrate the cuticle of the nematodes by transcuticular diffusion, altering the mechanisms of locomotion, besides causing cuticular lesions. Following in vitro evaluation, the acute and sub-chronic toxicity test should be performed to assess the toxicity of the bioactive compounds and to define the dose to be used in in vivo tests. In vivo tests are more reliable because the anthelmintic effectiveness of bioactive compounds is evaluated after the metabolization process. The metabolization process of the bioactive compounds can generate metabolites that exhibit or not anthelmintic effectiveness. The in vivo tests assessing the anthelmintic effectiveness of bioactive compounds in sheep and goats are the fecal egg count reduction test and the controlled test. OE promoted reduction of egg elimination in faeces which may be related to cuticular and reproductive alterations in GIN, and reduction of parasite burden in in vivo tests. Due to the promising results obtained with OE in the in vivo tests, interest has been aroused in using nanotechnology as an alternative to increase the bioavailability of OE and consequently, potentializing its anthelmintic effect, reducing the dose and toxicity of the biocompounds. In addition to nanotechnology, the isolation and chemical modification of compounds isolated from OE have been employed to obtain new molecules with anthelmintic action and understand the mechanism of action of EO on the small ruminant GIN.Conclusion: The use of EO and their compound bioactive in the control of resistant populations of GIN is a promising alternative. The adoption of strategies in which natural products can replace synthetic anthelmintics, such as in dry periods and use synthetic anthelmintics in the rainy season when the population in refugia in the pasture is high, thus reducing the dissemination of GIN resistant populations. As perspective, the evaluation of pharmacokinetics and pharmacodynamics of these natural products should be performed so that one defines treatment protocols that optimize the anthelmintic effect.

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Section: Efeito Anti-helmíntico De óLeos Essenciaisunclassified

Section: Atividade Anti-helmintica De Compostos Isolados De óLeosunclassified

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Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

André

Ribeiro

Oliveira

et al. 2018

Acta Scientiae. Vet.

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“…M. alternifolia essential oil (tea tree oil or TTO) is used to prepare solid lipid nanocarrier made with essential oil of Melaleuca (nanoTTO) and terpinen-4-ol (terp-4-ol). In investigation it was found that the TTO, nanoTTO and terp-4-ol were not toxic to liver and kidneys since hepatic and renal functions were not affected [55].…”

Section: Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

Chronic Kidney Diseases and Nanoparticle Therapeutics

Upadhyay¹

2017

J Tissue Sci Eng

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Present review article describes main causes of chronic kidney disease a major health problem public health problem round the globe. Disease has multiple etiologies related to sequential pathophysiological stages. It has major concern with chronic changes in renal structure and that severely alter glomerular filtration rate in patients. This article explains CKD biomarkers in brief i.e., serum creatinine, periostin, a matricellular protein discoidin domain receptor 1 (DDR1), a transmembrane collagen receptor of the tyrosine kinase family, Phospholipase D4 (PLD4) renal biomarkers, metabolic biomarkers. The main focus was given on use of nanoparticles for CKD therapeutics. This article describes various metal and metal oxide nanaoparticles, such as cuprous oxide (CONPs), super paramagnetic iron oxide (new SPIO) nanoparticles, silica-coated iron oxide nanoparticle, Vanadium oxide nanoparticles (VONPs, Titanium dioxide and gold, calcifying nanoparticles, colloidal protein-mineral nanoparticles, Liposomal nanoparticles, MITO-Porter, SB-coated NPs, ASc-loaded polymeric nanoparticles, Carbon-coated iron nanocrystal, Nanodiamonds, Sodium-PLGA hybrid nanoparticles, Epidermal growth factor receptor (EGFR)-targeted chitosan (CS) nanoparticles, Photocaged nanoparticles, Mesoporous silica nanoparticles (MSNs Quantum dots (QDs) which are used for drug delivery patients. For successful management of disease progression of diseases, symptoms should analyze by good physician at an eerily stage, by using highly efficacious, sensitive and specific CKD markers. All factors must include knowing the status of disease and chemotherapeutics by using low toxic nanoparticles. Before being used nanoparticles should evaluate in experiment animal models. For future therapeutics metabolomics, kidney transplants and good wound healers are required.

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Medicinal Plants Against Vesicular Stomatitis Virus (VSV) Infections: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies

Chandra

Sachan²,

Pathak³

et al. 2022

Reference Series in Phytochemistry

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Melaleuca alternifolia anthelmintic activity in gerbils experimentally infected by Haemonchus contortus

Cited by 34 publications

References 37 publications

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

Chronic Kidney Diseases and Nanoparticle Therapeutics

Medicinal Plants Against Vesicular Stomatitis Virus (VSV) Infections: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies

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