Melanin: A Naturally Existing Multifunctional Material

Eom, Taesik; Woo, Kyungbae; Shim, Bong Sup

doi:10.14478/ace.2016.1029

Cited by 20 publications

(9 citation statements)

References 40 publications

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“…The estimated energy band gap values for melanin are slightly dependent on the choice of substrates, annealing and on the interaction of TiO 2 nanoparticles as photocatalytic that induced stacking ordering in the polymeric chains. These values are comparable to the melanin E g values observed in the range from 1.0 to 1.4 eV [4,6,24,30,32,33,34]. We must be aware of the effect of Mie scattering that may be present at the longer wavelengths in the tail part of the spectra [3,4,6,9] affecting the energy band edge.…”

Section: Optical Absorptionsupporting

confidence: 73%

“…It is found that different behavior of the PL spectra in the range of 300-950 nm before annealing supports the significant substrate effects obtained previously from morphological and absorption analysis. The emission spectrum for 325 nm (3.8 eV) excitation reached the peaks maximum at around 550 nm obtained from melanin on glass substrates and then decreased monotonically with increasing emission wavelength [32,35], while the emission spectrum for melanin: TiO 2 blend on glass substrates (Fig. 6a) was reduced due to incorporation of the TiO 2 nanoparticles in the melanin matrix.…”

Section: Photoluminescence Spectroscopymentioning

confidence: 93%

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Formation of TiO2 nanostructures modified Eumelanin films with enhanced properties for biopolymer implementations

et al. 2020

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Optical Absorptionsupporting

confidence: 73%

Section: Photoluminescence Spectroscopymentioning

confidence: 93%

Formation of TiO2 nanostructures modified Eumelanin films with enhanced properties for biopolymer implementations

et al. 2020

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“…PHB is biodegradable and has been used in healthcare such as surgical sutures, nerve repair, and drug delivery. [ 28,77,79,80,81 ,] Melanins are naturally occurring conductive pigments, chemically characterized as heteropolymers of 5,6‐dihydroxyindole and 5,6‐dihydroxyindole‐2‐carboxylic acid. The electrical conductivity of melanin ranges from 10 −8 S cm −1 in the dehydrated state up to 10 −3 S cm −1 in the fully hydrated state.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable and Electrically Conductive Melanin‐Poly (3‐Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications

Agrawal

Vimal

Barzaghi

et al. 2022

Macromolecular Bioscience

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Due to the severity of peripheral nerve injuries (PNI) and spinal cord injuries (SCI), treatment options for patients are limited. In this context, biomaterials designed to promote regeneration and reinstate the lost function are being explored. Such biomaterials should be able to mimic the biological, chemical, and physical cues of the extracellular matrix for maximum effectiveness as therapeutic agents. Development of biomaterials with desirable physical, chemical, and electrical properties, however, has proven challenging. Here a novel biomaterial formulation achieved by blending the pigment melanin and the natural polymer Poly-3-hydroxybutyrate (PHB) is proposed. Physio-chemical measurements of electrospun fibers reveal a feature rich surface nano-topography, a semiconducting-nature, and brain-tissue-like poroviscoelastic properties. Resulting fibers improve cell adhesion and growth of mouse sensory and motor neurons, without any observable toxicity. Further, the presence of polar functional groups positively affect the kinetics of fibers degradation at a pH (≈7.4) comparable to that of body fluids. Thus, melanin-PHB blended scaffolds are found to be physio-chemically, electrically, and biologically compatible with neural tissues and could be used as a regenerative modality for neural tissue injuries. A biomaterial for scaffolds intended to promote regeneration of nerve tissue after injury is developed. This biomaterial, obtained by mixing the pigment melanin and the natural polymer PHB, is biodegradable, electrically conductive, and beneficial to the growth of motor and sensory neurons. Thus, it is believed that this biomaterial can be used in the context of healthcare applications.

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“…Melanin is a natural dark pigment existing in living organisms, and the subtype eumelanin is the most abundant form consisting of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA). − Even though many research efforts have been devoted to elucidating the chemical structures, the detailed characterization of the melanin or melanin-like polymers (MLPs) remains a challenge. − Depending on the preparation method, the structure of the MLPs might differ in terms of various monomer compositions, conjugation, and chain length, which in turn changes their properties . For synthesizing the MLPs with a conducting feature, the conjugated backbone structure has to be generated under controlled oxidative conditions.…”

Section: Introductionmentioning

confidence: 99%

Highly Conductive Melanin-like Polymer Composites for Nonenzymatic Glucose Biosensors with a Wide Detection Range

Ozlu

Shim

2022

ACS Appl. Polym. Mater.

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Melanin is a natural biopolymer with a conjugated backbone that supposedly provides conductive pathways. However, few studies have synthesized electrically conductive melanin-like polymers (eMLPs) so far. In this study, highly electrically conductive melanin-like polymers (eMLPs) were electrochemically synthesized with tunable morphologies. After a bare gold electrode was coated with eMLP, the electrochemical performances were dramatically improved by a 2-order of magnitude decrease in impedance and up to a 60-fold increase in charge storage capacity. The morphology of the eMLP could be modulated by the ratios of carboxylic acid-bearing poly(L-3,4-dihydroxyphenylalanine) nanoparticles (PLDA NPs) to dopamine without compromising the electrochemical properties. Unlike conventionally insulating polydopamine, eMLP was demonstrated in glucose detection to be a nonenzymatic biosensor with high sensitivity (752.5 μA mM −1 cm −2 ), a low limit of detection (23 μM), a wide linear range up to 70 mM, and physiological selectivity. This eMLP composite with superior electrochemical performances can be utilized in a wide range of bioelectronics applications from in situ biosensors to implantable bionic interfaces.

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Melanin: A Naturally Existing Multifunctional Material

Cited by 20 publications

References 40 publications

Formation of TiO2 nanostructures modified Eumelanin films with enhanced properties for biopolymer implementations

Formation of TiO2 nanostructures modified Eumelanin films with enhanced properties for biopolymer implementations

Biodegradable and Electrically Conductive Melanin‐Poly (3‐Hydroxybutyrate) 3D Fibrous Scaffolds for Neural Tissue Engineering Applications

Highly Conductive Melanin-like Polymer Composites for Nonenzymatic Glucose Biosensors with a Wide Detection Range

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