2014
DOI: 10.4172/2376-0427.1000127
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Melanocytes and Oxidative Stress

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Cited by 11 publications
(9 citation statements)
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References 77 publications
(87 reference statements)
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“…superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and thioredoxin reductase (TR)) and non-enzymatic (e.g. ascorbic acid, glutathione) antioxidants, along with various antioxidant genes, including heme-oxygenase 1 (HO-1), ferritin, and master regulator of the antioxidant response−nuclear factor erythroid 2–related factor 2 (NRF2) [ [16] , [17] , [18] , [19] ].…”
Section: Introductionmentioning
confidence: 99%
“…superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and thioredoxin reductase (TR)) and non-enzymatic (e.g. ascorbic acid, glutathione) antioxidants, along with various antioxidant genes, including heme-oxygenase 1 (HO-1), ferritin, and master regulator of the antioxidant response−nuclear factor erythroid 2–related factor 2 (NRF2) [ [16] , [17] , [18] , [19] ].…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the oxygen levels in the highly compact DP-hMel aggregates are also likely to be below 5%O 2 and lead to the formation of ROS by an alternative mechanism [19], as it was previously demonstrated to play a key role in the stimulation of DP cells inductivity [22]. Moreover, ROS increase in the 3D-cellular aggregates may also be a consequence of the improved tyrosinase activity which is, by itself, a ROS-generating oxidative step [51,52]. Moreover, albeit a direct correlation was not observed in at cultures, in the 3D-cell aggregates both ROS levels and ALP activity were higher in physoxia than in normoxia, demonstrating that in a more complex environment the native interactions between hMel and DP cells can be better represented.…”
Section: Discussionmentioning
confidence: 93%
“…Our previous studies demonstrated that extract of China camellia inhibited tyrosinase activity and proliferation of melanocytes . Moreover, camellianin A exhibits potent antioxidant activity, while oxidative stress can cause hyperpigmentation . Thus, both antioxidant and inhibition of melanogenesis properties of China camellia can contribute to improvements in pigmentation in melasma following the treatments with the test cream.…”
Section: Discussionmentioning
confidence: 99%