Melanocytic matricoma: an additional case with literature review over this rare entity

Maashari, Raghda Al; Hamodat, Mowafak

doi:10.15436/2381-0858.17.1394

Cited by 2 publications

(3 citation statements)

References 42 publications

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“…Furthermore, basal cell carcinoma is positive for Ber-EP4 stain, whereas melanocytic matricoma remains negative in the basaloid component. 10 In addition, benign follicular neoplasms can resemble melanocytic matricoma; for example, infrequent pigmented variants of trichoblastoma with a dendritic melanocyte population have been reported in the literature (melanotrichoblastoma) with a prominent solid basaloid population and nodular growth pattern, although keratinized cellularity was not observed. 28 In the case of melanocytic malignancies such as malignant melanoma, intraepidermal pagetoid spread with junctional activity of pleomorphic melanocytes are distinctive features, rarely seen in melanocytic matricoma.…”

Section: Discussionmentioning

confidence: 99%

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Melanocytic Matricoma With Atypical Histopathological Features: A Case Report of an Extremely Rare Entity and Review of the Literature

Nogales-Moro

Pinilla-Pagnon

Silvestre-Torner

et al. 2023

The American Journal of Dermatopathology

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Melanocytic matricoma with atypical features is a rare, biphasic adnexal neoplasm displaying hair matrix differentiation, with only 3 reported cases worldwide. Generally, the lesion comprised a solid matrical and supramatrical cell proliferation, admixed with intermediate cell aggregates with sparse anucleated "shadow cells" and a prominent pigmented melanocytic hyperplasia. We report the case of a 78-year-old man with a slow-growing crusted lesion on the frontal left scalp, which in a matter of 1-2 months became a 0.6 cm well-defined, black purplish exophytic nodule. Histopathologically, the lesion presented a well-circumscribed border with a nodular dermal growth pattern, presenting different architectural features varying from benign pilomatricoma-like changes to atypical features such as moderate-to-high nuclear pleomorphism in both basaloid (matrical/supramatrical) and epidermal (keratinous) components. Strong nuclear and cytoplasmic positivity for b-catenin was observed in matrical cells, whereas prominent cytoplasmic membrane positivity for Melan-A in dendritic melanocytes. Owing to the evidence of atypical cytological features, we propose the "atypical/borderline" category of melanocytic matricoma as part of a possible spectrum among matrical neoplasms. Pathologists should be aware of any atypical histopathological features while reporting cases due to their potential malignant transformation.

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Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, there has been only 3 of the 32 cases that have been reported worldwide with atypical features (Table 1). 1–24 This case provides evidence of atypical cytological characteristics in both matrical and keratinous cell populations to propose the “atypical/borderline” category.…”

Section: Introductionmentioning

confidence: 88%

Melanocytic Matricoma With Atypical Histopathological Features: A Case Report of an Extremely Rare Entity and Review of the Literature

Nogales-Moro

Pinilla-Pagnon

Silvestre-Torner

et al. 2023

The American Journal of Dermatopathology

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“…According to our review of the literature, 26 cases of melanocytic matricoma have been reported to date (Table 1). 1‐21 We present three additional cases of melanocytic matricoma, reported within the last 3 years at a large, UK‐based, tertiary dermatopathology referral center. We discuss the histopathological, immunohistochemical, and molecular features, and highlight the features of malignancy.…”

Section: Introductionmentioning

confidence: 99%

Melanocytic matricoma: A report of three cases, review of the literature, and suggestion of a new terminology

Ferrier

Husain

2022

J Cutan Pathol

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Melanocytic matricoma is a rare, biphasic adnexal tumor. It typically presents as a pigmented papule on the sun‐damaged skin of elderly patients. Histopathology shows a dermal nodule composed of basaloid cells, ghost cells, and deeply pigmented dendritic melanocytes. The basaloid cells are usually positive for β‐catenin and these tumors show overlapping histopathological and molecular features with pilomatricoma. Here, we review the literature on melanocytic matricoma and present three new cases. We suggest different terminology to reflect the overlapping features with pilomatricoma that recognizes that melanocytic matricoma is likely to be a variant of pilomatricoma associated with melanocytic hyperplasia. Although melanocytic matricoma is usually considered benign, malignant transformation has been reported. This highlights the need for increased awareness of this entity.

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Melanocytic matricoma: an additional case with literature review over this rare entity

Cited by 2 publications

References 42 publications

Melanocytic Matricoma With Atypical Histopathological Features: A Case Report of an Extremely Rare Entity and Review of the Literature

Melanocytic Matricoma With Atypical Histopathological Features: A Case Report of an Extremely Rare Entity and Review of the Literature

Melanocytic matricoma: A report of three cases, review of the literature, and suggestion of a new terminology

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