Melanoma metastases in the abdomen and pelvis: Frequency and patterns of spread

Abstract

AIM:To investigate the frequency, typical and atypical locations and patterns of melanoma metastases identifiable by computed tomography (CT) in the abdomen and pelvis. METHODS:We performed a retrospective review of index CT examinations of the abdomen and pelvis in patients with melanoma and recorded all findings suggestive of metastatic disease. RESULTS:Metastases were present on 36% (181/508) of the index examinations and most commonly involved the liver (47%) and pelvic lymph nodes (27%). Lower extremity primaries had the highest rate of metastasis (52%). Ocular and head and neck melanomas have a predilection to metastasize to the liver (hepatic involvement in 70% and 63%, respectively, of patients with metastatic disease) and metastases from lower extremity primaries most commonly involve pelvic lymph nodes (54% of patients with metastatic disease). Metastases to atypical locations were present in 14% of patients and most commonly occurred in the subcutaneous tissue and spleen. Primary tumors of the lower extremity, back and head and neck were most commonly associated with atypical metastases. Pelvic metastases are more common with lower extremity primaries (accounting for 70% of cases with pelvic metastases) but 5% of patients with supraumbilical primaries also had pelvic metastases. CONCLUSION:The distribution of metastatic melanoma in the abdomen and pelvis that we have defined should help guide the interpretation of CT exams in these patients.

Circulating tumour cell liquid biopsy in selecting therapy for recurrent cutaneous melanoma with locoregional pelvic metastases: a pilot study

“…1 Department of Applied Clinical Sciences and Biotechnology, University of L' Aquila, 67100 L' Aquila, Italy. 2 Department of Oncology and Hematology, Ospedali Riuniti Marche Nord, 61121 Pesaro, Italy. 3 Research Genetic Cancer…”

“…Approximately 10% of cutaneous melanomas (CMs) recur as locoregional metastases following treatment [1]. Of these, ≈ 15% involve the pelvis [2], with only 2% of pelvic/inguinal metastases presenting in the absence of leg lesions [3]. Over the past 15 years, local, regional and systemic treatments for locoregional metastatic melanoma have evolved.…”

Hasfali endometriosis: differenciáldiagnosztikai nehézségek a radiológus szemszögéből

“…Egy betegség emelendő ki, a melanoma malignum, melynek korspecifikus incidenciája ebben az életkorban kezd növekedni. Ritkán adhat hasfalon subcutan vagy izomban elhelyezkedő metasztázist, mellyel viszont számolni kell [26,27].…”

Does Locoregional Chemotherapy Still Matter in the Treatment of Advanced Pelvic Melanoma?

“…Therefore, in the last six years, options for treatment of advanced melanoma patients have significantly changed, thanks to new target therapy and immunotherapy. The new era of effective systemic therapy, also involves patients with pelvic locoregional metastases without lesions in the legs, which are approximately less than 2% of all malignant melanoma patients [ 3 , 4 ].…”