Melanomas and mast cells: an ambiguous relationship

Abstract

Mast cells (MCs) accumulate in a broad range of tumors, including melanomas. While MCs are potent initiators of immunity in infection, and in allergic inflammation, the function of MCs in anti-melanoma immunity is unclear. MCs have the potential to release tumoricidal cytokines and proteases, to activate antigen-presenting cells and to promote anti-tumor adaptive immunity. However, within the immunosuppressive tumor microenvironment (TME), MC activation may promote angiogenesis and contribute to tumor growth. In this review, the relationship between MCs and melanomas is discussed with a focus on the impact of the TME on MC activation.

Angiogenesis Still Plays a Crucial Role in Human Melanoma Progression

“…This finding raises the possibility that in filtrating mast cells and lymphocytes have an inhibitory effect, as demonstrated prev ously. A recent review article underscored the potential role of mast cells in promotin the growth and invasiveness of melanoma [103].…”

Melanoma-associated fibroblasts in tumor-promotion flammation and antitumor immunity: novel mechanisms and potential immunotherapeutic strategies

“…Males experience more frequent occurrences, with 174 000 yearly cases compared to females, with 151 000 cases [ 1 , 2 ]. The intricate dynamics between cancer cells and their microenvironment have come to the forefront of melanoma research, revealing a complex interplay that significantly influences disease progression [ 3 ]. Within this dynamic landscape, fibroblasts emerge as pivotal players, particularly cancer-associated fibroblasts (CAFs).…”