1997
DOI: 10.1016/s0898-6568(96)00137-4
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Melatonin Agonists Induce Phosphoinositide Hydrolysis in Xenopus Laevis Melanophores

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Cited by 16 publications
(11 citation statements)
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“…However, these effects were not concentration dependent, and therefore, their physiological significance (e.g., to pigment aggregation) under the experimental conditions described here remains to be elucidated. Although X. laevis melanophores possess melatonin-binding sites that are linked to phosphoinositide hydrolysis (10,23), modulation of cellular IP 3 level, in addition to PLC, may also be related to 1-phosphatidylinositol (PI) and phosphatidylinositol 4-monophosphate (PIP) kinases (44). Reduction of cellular IP 3 (downregulation of signal transduction) by several flavonoids and some other compounds has been proposed for murine and human carcinomas and cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…However, these effects were not concentration dependent, and therefore, their physiological significance (e.g., to pigment aggregation) under the experimental conditions described here remains to be elucidated. Although X. laevis melanophores possess melatonin-binding sites that are linked to phosphoinositide hydrolysis (10,23), modulation of cellular IP 3 level, in addition to PLC, may also be related to 1-phosphatidylinositol (PI) and phosphatidylinositol 4-monophosphate (PIP) kinases (44). Reduction of cellular IP 3 (downregulation of signal transduction) by several flavonoids and some other compounds has been proposed for murine and human carcinomas and cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…Activation of PI turnover by melatonin receptors has been demonstrated in hamster melanoma cells [55], avian brains [56], Xenopus melanophores [57] and neuroblastoma cells [58]. Thus far, three subfamilies of PLC isozyme, designated as PLC-ß, -‰, and -Á, have been identified.…”
Section: Regulation Of Phospholipase Cmentioning
confidence: 99%
“…It should be noted that a PTX-insensitive G protein may be involved in melatonin-induced PI turnover in Xenopus melanophores [57]. Mel 1c receptor, which is cloned from Xenopus melanophores, is unable to couple to G· q/11/14 [34] and G· 16 [29].…”
Section: Regulation Of Phospholipase Cmentioning
confidence: 99%
“…Entretanto, os receptores de melatonina também podem se associar à proteína G que provoca a ativação da PLC e geração de IP 3 (Brydon et al, 1999;Lai et al, 2002;Steffens et al, 2003), inclusive em melanócitos de Xenopus (Mullins et al, 1997) e dinoflagelados (Tsim et al, 1997 (Woodcock, 1996). DAG ativa varios isômeros de proteína quinase C (PKC) enqunato que o IP 3 tem a importante função na liberação de Ca 2+ de compartimentos intracelulares (Berridge, 1987) (figura 5).…”
Section: 32via De Sinalização Induzida Pela Melatonina Em Plasmodiumunclassified
“…O pré-tratamento das células com cloreto de lítio (LiCl) foi necessário para evitar a desfosforilação dos inositóis fosfatos (Elabbadi et al, 1994;Irvine et al, 1985;Thomas et al, 1984). Em mamíferos os receptores de melatonina podem se associar à proteína G que provoca a ativação da PLC e geração de IP 3 (Brydon et al, 1999;Lai et al, 2002;Steffens et al, 2003), esta via de sinalização ativada pela melatonina já foi demonstrada em melanócitos de Xenopus (Mullins et al, 1997) e dinoflagelados (grupo-irmão dos Apicomplexas) (Tsim et al, 1997). A ausência de uma proteína G identificada no genoma de Plasmodium sugere que a identidade do receptor de melatonina em P. falciparum seja distinta do hospedeiro humano.…”
Section: Eritrócitos Infectados Com Parasitas Dessincronizados Foram unclassified